Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
Language: Английский
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 24, 2025
C–C bond cleavage and recombination provide an efficient strategy for the modification reconstruction of molecule structures. Herein, we present a method achieving amidation aryl C(sp2)–H through triple with involvement nitrous acid esters. This marks instance precise controlled stepwise bond, offering fresh perspective such bonds. Nitrous ester serves as both radical source hydrogen atom transfer (HAT) reagent to functionalize utilize two carbon atoms bond. The alkoxy captures from or N-hydroxyl induce 1,3-oxygen migration, which is crucial subsequent molecular authors report achieve bonds by participation
Language: Английский
Citations
5
Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(8), P. 2195 - 2200
Published: Jan. 1, 2024
A Heck-like coupling of cyclic sulfonium salts with alkenes via selective C–S bond cleavage using a copper complex as photosensitizer through visible-light-driven redox-neutral process has been developed.
Language: Английский
Citations
9
Fuel, Journal Year: 2024, Volume and Issue: 366, P. 131356 - 131356
Published: March 2, 2024
Language: Английский
Citations
5
Organic Letters, Journal Year: 2023, Volume and Issue: 25(30), P. 5563 - 5568
Published: July 21, 2023
A redox-neutral copper-catalyzed cascade reaction involving alkoxyl radical-mediated ring expansion/1,4-difunctionalization of 1,3-enynes was developed, offering a straightforward approach to the tetra-substituted allenes with macrolactone, CN, and CF3 functional groups. Remarkably, incorporation NH2 group onto 1,3-enyne moiety enabled further cyclization give unique scaffold containing lactone an indole moiety.
Language: Английский
Citations
13
Organic Letters, Journal Year: 2024, Volume and Issue: 26(34), P. 7170 - 7175
Published: Aug. 19, 2024
A cascade reaction of cyclopropyl alcohols, DABSO (1,4-diazoniabicyclo[2.2.2]octane-1,4-disulfinate), and N-(sulfonyl)acrylamides has been developed. This tandem process went through a cyclopropanol ring opening Michael addition sequence. The γ-keto sulfinate generated from the between serves as nucleophilic reagent, N-(sulfonyl)acrylamide is used acceptor. By utilizing this strategy, multitudinous sulfone-bridged 1,7-dicarbonyl compounds that contain both β-sulfonyl amide unit sulfone skeleton were conveniently synthesized.
Language: Английский
Citations
4
Organic Letters, Journal Year: 2023, Volume and Issue: 25(48), P. 8733 - 8738
Published: Nov. 22, 2023
A photoredox-catalyzed approach for the difluoroalkylation of amino acids was achieved through simultaneous decarboxylation and defluorination processes. This innovative protocol employs commonly available trifluoroacetophenones as primary starting materials, eliminating necessity preactivation. strategy has enabled synthesis several difluoroketone functionalized amines in moderate to impressive yields. These synthesized compounds are presented foundational molecules subsequent modification. The underlying mechanism transformation is anchored a single electron transfer (SET) radical pathway.
Language: Английский
Citations
8
ChemCatChem, Journal Year: 2023, Volume and Issue: 15(23)
Published: Oct. 17, 2023
Abstract Transition‐metal‐catalyzed radical relay cross‐coupling reactions of 1,3‐dienes have recently emerged as one the most powerful methods for construction structurally diverse allylic compound in a single chemical step. However, there still has been limited success expanding substrate scope precursors and coupling partners, well exploring catalytic asymmetric variants. Herein, we report copper‐catalyzed enantioselective three‐component 1,2‐alkylesterification using cycloalkyl hydroperoxides carbonyl‐containing alkyl sources carboxylic acids O‐nucleophiles under mild redox‐neutral conditions. This protocol features broad good functional group tolerance with respect to each component, providing practical access variety distally keto‐functionalized esters high enantioselectivity. Mechanistic studies suggest involvement sequential C−O this reaction.
Language: Английский
Citations
6
The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(14), P. 9927 - 9940
Published: July 11, 2023
An array of redox-neutral alkylation/cyclization cascade reactions N-functionalized acrylamides with cycloalkyl hydroperoxides were achieved via the alkoxyl radical-triggered C-C bond cleavage. Through adjusting radical acceptors on N atom, a variety keto-alkylated chain-containing azaheterocycles, including indolo[2,1-a]isoquinolin-6(5H)-ones, quinoline-2,4-diones, and pyrido[4,3,2-gh]phenanthridines constructed by one-pot procedure good yields excellent functional group tolerance.
Language: Английский
Citations
4
Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
Language: Английский
Citations
1