Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(45), P. 9659 - 9664
Published: Oct. 31, 2024
1,3-Difunctionalization
of
donor–acceptor
cyclopropanes
with
copper
nitrate
and
N-halosuccinimide
was
developed
to
efficiently
afford
γ-halonitrates.
The
pivotal
factor
this
protocol
lies
in
the
dual
role
as
a
Lewis
acid
an
ideal
nitrooxy
source.
given
approach
features
easy
handling,
good
functional
group
compatibility,
wide
substrate
scope.
Furthermore,
various
transformations
obtained
γ-chloronitrates
underscore
remarkable
synthetic
potential
inherent
method.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(11), P. 2158 - 2162
Published: March 8, 2024
The
C–C
bond
in
non-activated
cyclopropanes
can
be
intramolecularly
cleaved
with
an
electrochemically
generated
amidyl
radical
forming
oxazolines.
In
the
presence
of
TBABF4,
this
provides
1,3-oxyfluorination
products.
cleavage
cyclopropane
proceeds
inversion
configuration,
suggesting
intramolecular
homolytic
substitution
(SHi)
mechanism.
performance
TBABF4
as
efficient
fluoride
source
was
explained
by
accumulation
BF4–
anion
at
anode
surface,
which
a
carbocation
is
formed
oxidation
C-centered
radical.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 23, 2025
Crop
protection
globally
is
under
threat
from
infections
caused
by
plant-parasitic
nematodes
(PPNs).
PPNs
can
wreak
havoc
on
agricultural
production.
However,
only
limited
nematicides
are
currently
available,
and
the
growing
resistance
problem
a
concern;
therefore,
novel
urgently
needed.
Thirty-three
trifluorobutene
ester
derivatives
were
synthesized,
then
their
biological
activity
against
Meloidogyne
incognita
was
tested
in
this
study.
Among
them,
nine
compounds
exhibited
excellent
vitro
bioactivity
M.
incognita;
LC50/72h
values
reached
1.77-3.95
mg/L.
In
addition,
derivative
of
active
compound
above
containing
piperazine
ring
significant
vivo
with
an
inhibition
rate
77.3%
at
1.25
mg/L
matrix.
The
structure-activity
relationships
(SARs)
all
synthesized
analyzed,
further
comparative
molecular
field
analysis
(CoMFA)
calculated
to
discuss
SAR
profile.
preliminary
mechanisms
action
study
suggested
that
some
had
great
inhibitory
effect
egg
hatching,
motility,
feeding
ability,
growth
Caenorhabditis
elegans.
Meanwhile,
effects
biochemical
indices
related
oxidative
stress
indicated
two
could
significantly
promote
induce
toxicity
through
damage.
Current Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
28(7), P. 489 - 509
Published: March 14, 2024
Abstract:
Among
the
several
peroxides
available,
meta-chloroperbenzoic
acid
(mCPBA)
plays
an
efficient
role
of
oxidizing
reagent
and
is
used
for
many
oxidative
transformations,
such
as
oxidation
various
functional
groups,
carbon-carbon,
carbon-hetero
bond
formation,
heterocyclic
ring
heteroarylation,
cross-coupling,
lactonization,
dearomatization,
α-oxytosylation
or
α-acetoxylation,
C-C
activation
in
other
miscellaneous
reactions.
The
purpose
this
review
to
critically
discuss
significant
contributions
mCPBA
along
with
hypervalent
iodine/iodine
reagents
organic
synthesis
from
mid-2015
date.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(37), P. 6919 - 6924
Published: Sept. 11, 2023
Herein,
a
general
electrochemical
radical-cation-mediated
four-component
ring-opening
1,3-alkyloxylimidation
of
arylcyclopropanes,
acetonitrile,
carboxylic
acids,
and
alcohols
is
described,
providing
facile
sustainable
approach
to
quickly
construct
structurally
diverse
imide
derivatives
from
easily
available
raw
materials
in
an
operationally
simple
undivided
cell.
This
metal-catalyst-
oxidant-free
single-electron
oxidation
strategy
offers
green
alternative
for
the
formation
highly
reactive
cyclopropane-derived
radical
cations,
this
protocol
features
broad
functional
group
tolerance.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(10), P. 2085 - 2090
Published: March 5, 2024
In
this
paper,
we
describe
a
Re2O7-mediated
ring-opening
arylation
of
unactivated
arylcyclopropane
because
its
functionalization
with
various
arenes
via
Friedel–Crafts-type
reactivity.
This
protocol
allows
facile
access
to
functionalized
1,1-diaryl
alkanes
and
is
characterized
by
broad
substrate
scope,
mild
reaction
conditions,
high
efficiency,
atom
economy.
Both
density
functional
theory
calculations
deuterium
labeling
experiments
were
carried
out
justify
the
indispensable
role
HFIP
in
transformation
pointed
ring
opening
being
rate-determining
step.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Cooperative
NHC/photoredox
catalyzed
deconstruction–reconstruction
of
aryl
cyclopropanes
was
described
to
access
various
α-acylated
cyclopropane
derivatives.
Beilstein Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
20, P. 701 - 713
Published: April 3, 2024
We
report
the
detailed
background
for
discovery
and
development
of
synthesis
homopropargylic
azides
by
azido-alkynylation
alkenes.
Initially,
a
strategy
involving
SOMOphilic
alkynes
was
adopted,
but
only
resulted
in
29%
yield
desired
product.
By
switching
to
radical-polar
crossover
approach
after
optimization,
high
(72%)
azide
reached.
Full
insights
are
given
about
factors
that
were
essential
success
optimization
process.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
highlight
summarises
electrochemical
approaches
for
the
deconstructive
functionalization
of
arylcycloalkanes
via
fragmentation
anodically
generated
aromatic
radical
cations.
