
Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(12), P. 106027 - 106027
Published: Oct. 22, 2024
Language: Английский
Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(12), P. 106027 - 106027
Published: Oct. 22, 2024
Language: Английский
Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(18), P. 5144 - 5150
Published: Jan. 1, 2024
A transition-metal-free multi-functionalization reaction of β-trifluoromethyl enones and azacycles is first developed for the synthesis valuable amino-2,3-dihydrofuran derivatives.
Language: Английский
Citations
4The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 5, 2025
Enantioselective functionalization of 4-aminoindoles at the site-specific C7 position via a chiral phosphoric acid-catalyzed Friedel-Crafts reaction with cyclic thioimidates was developed. This approach enables formation 4,7-difunctionalized indoles incorporating N,S-acetal motif excellent yield and enantioselectivity (up to 99% >99% ee). The protocol is also compatible isatin-derived ketoimines for highly enantioselective synthesis indole derivatives bearing aza-quaternary carbon position. synthetic potential demonstrated by gram-scale experiments versatile transformations products, method characterized low catalyst loading, site specificity, enantioselectivity, broad substrate scope.
Language: Английский
Citations
0Synthesis, Journal Year: 2024, Volume and Issue: 56(15), P. 2403 - 2409
Published: April 4, 2024
Abstract 4′-Nitro-2H-spiro[acenaphthylene-1,2′-pyrrolidine]-2-one derivatives are prepared via [3+2] cycloaddition reactions of azomethine ylides, generated in situ from acenaphthoquinone and primary amines, with β-nitrostyrenes the presence ( i Pr)2NEt methanol. Evidence for structures products was obtained single-crystal X-ray analysis. The important feature this diastereoselective synthesis NH-unprotected spiropyrrolidines is formation four contiguous stereogenic centers, one which quaternary, high selectivity.
Language: Английский
Citations
1New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(14), P. 6322 - 6334
Published: Jan. 1, 2024
This is the first example of harmaline scaffolds as acceptor/acceptor-based N–C–C synthons and evaluation 3at an anticancer agent.
Language: Английский
Citations
0The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(12), P. 8500 - 8512
Published: June 6, 2024
A highly enantioselective protocol for the conjugate addition of 2-arylimidazo[1,2-
Language: Английский
Citations
0The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(16), P. 11607 - 11619
Published: Aug. 1, 2024
A highly efficient asymmetric [3 + 2] cycloaddition reaction of 2'-hydroxychalcones with
Language: Английский
Citations
0Organic Letters, Journal Year: 2024, Volume and Issue: 26(34), P. 7261 - 7266
Published: Aug. 21, 2024
A copper-catalyzed trifluoromethylation of benzene-linked 1,7-dienes with 1-trifluoromethyl-1,2-benziodoxole via a radical cascade cyclization process for the synthesis mono- and bis-trifluoromethylated benzoxepines is developed. The selectivity depends on substituents double bond allyl group in 1,7-dienes. large-scale operation late-stage functionalization bioactive molecules reveal promising utility this protocol.
Language: Английский
Citations
0Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(12), P. 106027 - 106027
Published: Oct. 22, 2024
Language: Английский
Citations
0