Organocatalyst as a synthetic gadget for pharmaceutically potent molecules DOI Creative Commons

Labiqa Aman,

Shehla Khalid, Nasır Rasool

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(12), P. 106027 - 106027

Published: Oct. 22, 2024

Language: Английский

Multi-functionalization of β-trifluoromethyl enones enabled 2,3-dihydrofuran synthesis DOI

Ya-Fei Hu,

Wei Han,

Ye-Kun Chen

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(18), P. 5144 - 5150

Published: Jan. 1, 2024

A transition-metal-free multi-functionalization reaction of β-trifluoromethyl enones and azacycles is first developed for the synthesis valuable amino-2,3-dihydrofuran derivatives.

Language: Английский

Citations

4
Enantioselective Friedel–Crafts Reaction for the Synthesis of 4,7-Difunctionalized Indoles Featuring a Chiral Heteroatom-Substituted Quaternary Carbon at the C7 Position DOI
Xiaoyu Zhong,

X. Xue,

Qiao-Qiao Peng

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Enantioselective functionalization of 4-aminoindoles at the site-specific C7 position via a chiral phosphoric acid-catalyzed Friedel-Crafts reaction with cyclic thioimidates was developed. This approach enables formation 4,7-difunctionalized indoles incorporating N,S-acetal motif excellent yield and enantioselectivity (up to 99% >99% ee). The protocol is also compatible isatin-derived ketoimines for highly enantioselective synthesis indole derivatives bearing aza-quaternary carbon position. synthetic potential demonstrated by gram-scale experiments versatile transformations products, method characterized low catalyst loading, site specificity, enantioselectivity, broad substrate scope.

Language: Английский

Citations

0
Diastereoselective Synthesis of NH-Unprotected Spiropyrrolidines via the Huisgen Reaction of Acenaphthoquinone-Derived Azomethine Ylides with β-Nitrostyrenes DOI
Issa Yavari,

Kiyana Ghafouri

Synthesis, Journal Year: 2024, Volume and Issue: 56(15), P. 2403 - 2409

Published: April 4, 2024

Abstract 4′-Nitro-2H-spiro[acenaphthylene-1,2′-pyrrolidine]-2-one derivatives are prepared via [3+2] cycloaddition reactions of azomethine ylides, generated in situ from acenaphthoquinone and primary amines, with β-nitrostyrenes the presence ( i Pr)2NEt methanol. Evidence for structures products was obtained single-crystal X-ray analysis. The important feature this diastereoselective synthesis NH-unprotected spiropyrrolidines is formation four contiguous stereogenic centers, one which quaternary, high selectivity.

Language: Английский

Citations

1
Design, synthesis and evaluation of structurally diverse polycyclic harmaline scaffolds as anticancer agents DOI
Shuang Chen, Xirui Wang, Weina Wang

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(14), P. 6322 - 6334

Published: Jan. 1, 2024

This is the first example of harmaline scaffolds as acceptor/acceptor-based N–C–C synthons and evaluation 3at an anticancer agent.

Language: Английский

Citations

0
Highly Enantioselective Lewis Acid Catalyzed Conjugate Addition of Imidazo[1,2-a]pyridines to α,β-Unsaturated 2-Acylimidazoles under Mild Conditions DOI Creative Commons
Maria Eduarda C. Thedy, Vanessa Pereira,

Caio R. Dos Santos

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(12), P. 8500 - 8512

Published: June 6, 2024

A highly enantioselective protocol for the conjugate addition of 2-arylimidazo[1,2-

Language: Английский

Citations

0
Chiral-Boron Complex-Catalyzed Asymmetric [3 + 2] Cycloaddition of 2′-Hydroxychalcones with N-2,2,2-Trifluoroethylisatin Ketimines DOI

Guo-Li Chai,

Xiao Wang,

Wei‐Yu Huang

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(16), P. 11607 - 11619

Published: Aug. 1, 2024

A highly efficient asymmetric [3 + 2] cycloaddition reaction of 2'-hydroxychalcones with

Language: Английский

Citations

0
Substituent-Controlled Copper-Catalyzed Trifluoromethylation of 1,7-Dienes: Synthesis of Mono- and Bis-trifluoromethylated Benzoxepines DOI
Xiaowei Zhao, Xiang Gao,

Fangli Zhao

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(34), P. 7261 - 7266

Published: Aug. 21, 2024

A copper-catalyzed trifluoromethylation of benzene-linked 1,7-dienes with 1-trifluoromethyl-1,2-benziodoxole via a radical cascade cyclization process for the synthesis mono- and bis-trifluoromethylated benzoxepines is developed. The selectivity depends on substituents double bond allyl group in 1,7-dienes. large-scale operation late-stage functionalization bioactive molecules reveal promising utility this protocol.

Language: Английский

Citations

0
Organocatalyst as a synthetic gadget for pharmaceutically potent molecules DOI Creative Commons

Labiqa Aman,

Shehla Khalid, Nasır Rasool

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(12), P. 106027 - 106027

Published: Oct. 22, 2024

Language: Английский

Citations

0