Abstract
The
synthesis
of
indolizine
derivatives
was
achieved
through
the
reaction
pyridinium
1,4‐zwitterionic
thiolates
with
a
diverse
array
2‐methyl‐2‐nitro‐3‐aryloxiranes.
Subsequent
investigations
unveiled
synthetic
route
to
indolizines
via
stepwise
[(5+1)−1]
pathway,
unstable
pyridothiazines
serving
as
transient
intermediates.
DFT
calculations
elucidated
that
this
transformation
entails
sequential
annulation,
deacylation,
desulfurization,
and
oxidation
steps.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
A
remarkably
simple
and
efficient
double
defluorinative
[3
+
3]
annulation
approach
involving
N-phenyl-α-fluoro-α-phenylsulfonylacetamide
2-CF3-alkenes
to
access
N-phenyl-3,6-difluoropyridone
derivatives
has
been
achieved.
The
key
the
success
of
this
single-step
synthesis
difluoropyridones
is
strategic
utilization
for
consecutive
allylic
vinylic
substitution
reactions
a
desulfonylation
cascade.
We
could
also
show
that
these
serve
as
versatile
platform
C-6-selective
functionalizations.
Organic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
low
catalyst
loading
and
transition
metal-free
benzannulation
of
β,γ-alkynyl-α-keto
esters
CF
3
-alkenes
has
been
developed
through
Michael-triggered
[3
+
3]
annulation.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
We
describe
a
novel
approach
for
synthesizing
diverse
fused
heterocyclic
compounds
by
utilizing
sequential
silver(I)
catalyzed
reaction
between
readily
obtainable
N-amidonaphthyridin
ylide
and
dialkyl
acetylenedicarboxylates.
This
method
provides
an
efficient
the
selective
synthesis
of
tetracyclic
ring-fused
1,6-naphthyridine
isoquinoline
derivatives,
offering
exceptional
structural
diversity.
In
addition,
title
constitute
interesting
class
luminophores
with
tunable
emission
solvatochromicity.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(9), P. 2003 - 2007
Published: March 12, 2024
Abstract
A
DBU‐promoted
[3+2]
cyclization/retro‐Mannich
cascade
reaction
of
N
‐aminoisoquinolinium
and
‐aminoquinolinium
derivatives
with
para
‐quinone
methides
has
been
established,
employing
a
C=C
double
bond
cleavage.
broad
range
salts,
are
well
tolerated,
providing
the
corresponding
rearrangement
products.
Moreover,
scaled‐up
reactions
diverse
derivatizations
products
were
also
investigated
discussed.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
The
indole
skeleton
exists
widely
in
natural
products,
pharmaceuticals,
and
materials.
We
disclose
here
a
trifluoromethyl
group
induced
regioselective
Larock
synthetic
method
from
unsymmetric
2-CF3-1,3-enynes.
presence
of
is
determinable
for
the
regioselectivity.
Once
CF3
was
replaced
with
methyl
or
phenyl
group,
ratio
1:1
to
1:1.4
isomers
were
obtained.
This
strategy
features
good
regioselectivity,
broad
substrate
scope,
high
functional
tolerance.
protocol
reported
offers
an
alternative
solution
rare
3,4-functionalization
products
further
transformed
show
distinctive
reactivity
hydroboration–oxidation
hydro-bromination.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(45), P. 9648 - 9653
Published: Nov. 1, 2024
An
unprecedented
five-component
[2
+
2
1
1]
benzannulation
strategy
for
regioselective
assembly
of
densely
functionalized
aromatic
amines
from
two
ynals,
malononitriles,
and
sodium
sulfinates
is
established.
The
protocol
enables
the
efficient
installation
five
substituents
on
a
benzene
ring
via
formation
multiple
chemical
bonds
in
single
operation,
providing
various
multifunctionalized
primary
moderate
to
good
yields.
Additionally,
three-component
[3
cycloaddition
NH4SCN
was
also
achieved
produce
2-amnopyridine
derivatives
with
serving
as
an
ammonia
surrogate.
Abstract
Organophosphorothioates
are
organic
molecules
containing
sulfur
and
phosphorus,
with
significant
biological
activity
physicochemical
properties,
widely
used
in
synthesis,
medicinal
chemistry,
the
agrochemical
industry.
In
particular,
many
phosphorothioates
display
a
variety
of
activities,
such
as
antifungal,
antibacterial,
anti‐parasite,
anticancer,
so
on.
Traditionally,
synthesis
has
mainly
relied
on
indirect
methods
involving
construction
S−P
bond.
recent
years,
direct
phosphorothiolation
gained
attention
reliable
rapid
method
for
introducing
−S−P(O)(OR)
2
group
into
parent
molecules.
This
article
reviews
latest
advances
reactions,
categorized
based
different
sources
group.
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 28, 2024
Abstract
Organoboron
compounds
are
recognized
as
essential
synthetic
intermediates
in
organic
chemistry
and
have
found
broad
applications
pharmaceutical
materials
science.
In
recent
years,
the
development
of
novel
boronating
reagents
has
opened
new
avenues
for
synthesis
organoboron
compounds.
Among
these,
N-heterocyclic
carbene
boranes
(NHC-boranes),
with
their
unique
advantages,
garnered
sustained
interest
evolved
into
important
precursors
boron-centered
radicals,
participating
a
diverse
array
visible-light-induced
borylation
reactions.
This
short
review
primarily
focuses
on
radical
reactions
involving
NHC-boranes,
summarizing
latest
advancements
field
offering
inspiration
subsequent
research.
1
Introduction
2
Photoinduced
Borylation
via
NHC-Boryl
Radicals
2.1
Polyfluoroarenes
2.2
Arenes
2.3
Alkenes
2.4
Alkynes
2.5
Other
Substrates
3
Conclusion
Future
Prospects
