Nickel-Catalyzed Electroreductive Heck Reaction: A Divergent Synthesis of C7- or C2-Arylindolines

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Herein, we present a novel electrochemically driven nickel-catalyzed Heck reaction of readily available N-arylacrylindoles for the construction both 7-arylindolines and 2-arylindolines. The proceeds in an undivided electrochemical cell employs sacrificial zinc anode as reductant. This catalytic protocol features consecutive electroreductive process under exceedingly mild conditions, with moderate yields. Detailed mechanistic studies indicate that involves domino sequence intramolecular arylation selective C-C or C-O bond cleavage, which could be accomplished by aryl migration carbethoxy removal.

Language: Английский

Palladium-Catalyzed Dearomative Heck/C(sp²)–H Activation/Decarboxylative Cyclization of C2-Tethered Indoles

Organic Letters, Journal Year: 2024, Volume and Issue: 26(43), P. 9389 - 9394

Published: Oct. 21, 2024

Until now, palladium-catalyzed dearomative Heck reactions of indoles were largely limited to β-H elimination and nucleophilic capture the transient alkyl-Pd(II) species. Herein, we disclose a novel Heck/C(sp

Language: Английский