Potassium Phosphate‐Mediated Synthesis of C4‐Phosphorylated Quinolines via Cascade Cycloisomerization of Ynones

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract A cascade phosphorylation cycloisomerization of readily accessible ynones and diphenylphosphine oxides facilitated by potassium phosphate is described, allowing for the straightforward synthesis C4‐phosphorylated quinoline scaffolds. The formation a C−P bond C−N achieved in single procedure without need pre‐assembled cores prior to phosphorylation. This transformation operates requirement metals or oxidants exhibits excellent compatibility with various functional groups. Furthermore, antimicrobial activity evaluation demonstrated that synthesized derivatives exhibited potent inhibitory against Staphylococcus aureus.

Language: Английский

Synthetic Versatility: The C-P Bond Odyssey

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

The review thoroughly examines recent progress in C–P bond formation reactions and considers the future directions this area of research.

Language: Английский