Synthesis of 3-(2-quinolyl) chromones from ynones and quinolineN-oxidesviatandem reactions under transition metal- and additive-free conditions DOI
Jing Liu,

Dan Ba,

Yanhui Chen

et al.

Chemical Communications, Journal Year: 2020, Volume and Issue: 56(29), P. 4078 - 4081

Published: Jan. 1, 2020

A novel method for the synthesis of 3-(2-quinolyl) chromones through a tandem [3+2] cycloaddition/ring-opening/O-arylation from ynones and quinoline N-oxides has been developed. This protocol proceeds under transition metal- additive-free conditions can be amplified to gram level in 91% yield. 3-(1-Isoquinolyl) 3-(2-pyridyl) are also successfully synthesized using isoquinoline pyridine basic conditions. Various heteroarene-contaning were afforded 30-98% yields, which difficult obtained compounds interest pharmaceutical chemistry chemical biology.

Language: Английский

Facile approach to multifunctionalized 5-alkylidene-3-pyrrolin-2-ones via regioselective oxidative cyclization of 2,4-pentanediones with primary amines and sodium sulfinates DOI
Donghan Liu,

Xihang Lu,

Qiaohe Zhang

et al.

Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(15), P. 4078 - 4084

Published: Jan. 1, 2022

Highly functionalized 5-alkylidene-3-pyrrolin-2-ones were efficiently synthesized via a four-component cascade cyclization/sulfonylation reaction between readily available 2,4-pentanediones, primary amines and sodium sulfinates under mild conditions.

Language: Английский

Citations

17
Base-promoted ring-closing carbonyl–allene metathesis for the synthesis of 2,4-disubstituted pyrroles DOI
Guolin Cheng,

Weiwei Lv,

Lulu Xue

et al.

Green Chemistry, Journal Year: 2018, Volume and Issue: 20(19), P. 4414 - 4417

Published: Jan. 1, 2018

The synthesis of 2,4-disubstituted pyrroles from N-propargyl β-enaminones via a ring-closing carbonyl–allene metathesis reaction is reported.

Language: Английский

Citations

32
Gold-catalyzed dual annulation of azide-tethered alkynes with nitriles: expeditious synthesis of oxazolo[4,5-c]quinolines DOI

Han Su,

Ming Bao, Chao Pei

et al.

Organic Chemistry Frontiers, Journal Year: 2019, Volume and Issue: 6(14), P. 2404 - 2409

Published: Jan. 1, 2019

A gold-catalyzed dual annulation of azide-tethered internal alkynes, which provides convenient access to quinoline derivatives, has been reported.

Language: Английский

Citations

28
Ruthenium(II) Acetate Catalyzed Synthesis of Silylated Oxazoles via C–H Silylation and Dehalogenation DOI
Shun Liu, Shiling Zhang, Qiao Lin

et al.

Organic Letters, Journal Year: 2019, Volume and Issue: 21(4), P. 1134 - 1138

Published: Feb. 1, 2019

An efficient ruthenium(II)-catalyzed intermolecular selective ortho C–H silylation of 2-aryloxazoles has been described for the first time, which provides a convenient and practical pathway synthesis versatile organosilane compounds with good functional group tolerance regioselectivity. This catalytic system could be also applied to dehalogenation Cl or Br group.

Language: Английский

Citations

27
Synthesis of 3-(2-quinolyl) chromones from ynones and quinolineN-oxidesviatandem reactions under transition metal- and additive-free conditions DOI
Jing Liu,

Dan Ba,

Yanhui Chen

et al.

Chemical Communications, Journal Year: 2020, Volume and Issue: 56(29), P. 4078 - 4081

Published: Jan. 1, 2020

A novel method for the synthesis of 3-(2-quinolyl) chromones through a tandem [3+2] cycloaddition/ring-opening/O-arylation from ynones and quinoline N-oxides has been developed. This protocol proceeds under transition metal- additive-free conditions can be amplified to gram level in 91% yield. 3-(1-Isoquinolyl) 3-(2-pyridyl) are also successfully synthesized using isoquinoline pyridine basic conditions. Various heteroarene-contaning were afforded 30-98% yields, which difficult obtained compounds interest pharmaceutical chemistry chemical biology.

Language: Английский

Citations

26