Frontiers in Chemistry,
Journal Year:
2020,
Volume and Issue:
8
Published: June 12, 2020
An
iodine/DMSO
catalyzed
selective
cyclization
of
N-tosylhydrazones
with
sulfur
without
adding
external
oxidant
was
developed
for
the
synthesis
4-aryl-1,2,3-thiadiazoles.
In
this
reaction,
oxidation
HI
by
using
DMSO
as
dual
and
solvent
is
key,
which
allowed
regeneration
I2,
ensuring
thus
success
synthesis.
This
protocol
features
simple
operation,
high
step-economy
(one-pot
fashion),
broad
substrate
scope
well
scale-up
ability.
Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(21), P. 6920 - 6924
Published: Oct. 25, 2018
A
one-pot,
protecting-group-free
benzannulation
of
2-alkenylindoles
with
readily
available
1,3-dicarbonyls
is
demonstrated
to
construct
structurally
diverse
carbazoles.
The
use
a
cheap
Brønsted
acid
catalyst
and
air
as
the
sole
oxidant
exemplifies
economic
viability
this
protocol.
execution
four
different
reactions
successively
generate
medicinally
important
indolocarbazole
core
also
achieved.
This
one-pot
method
paved
way
for
total
synthesis
three
alkaloids,
namely
staurosporinone,
arcyriaflavin
A,
7-hydroxy-K252c.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2019,
Volume and Issue:
7(9), P. 8798 - 8803
Published: April 11, 2019
A
practical
and
eco-friendly
method
for
the
clean
preparation
of
a
variety
Z-β-thiocyanate
alkenyl
esters
via
lactic
acid-catalyzed
multicomponent
hydrothiocyanation
reaction
was
established.
In
subgram-scale
synthesis,
were
exclusively
generated,
product
could
be
easily
isolated
in
high
purity
extraction.
large-scale
pure
products
simply
collected
through
liquid–liquid
separation.
The
acid
played
dual
function
transformation,
serving
as
recyclable
biomass
catalyst
medium.
The Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
84(5), P. 2941 - 2950
Published: Feb. 6, 2019
2,3-Disubstituted
benzofurans
were
synthesized
from
acrolein
dimer
and
1,3-dicarbonyl
compounds
by
using
N-bromosuccinimide
as
an
oxidizing
agent.
The
method
was
used
to
synthesize
two
commercial
drug
molecules,
benzbromarone
amiodarone.
proposed
mechanism
of
the
reaction
involves
a
(NBS)-assisted
autotandem
catalysis
with
Lewis
acid
catalyst.
To
proof
mechanism,
intermediate
isolated
successfully,
which
can
be
converted
4,5,6,7-tetrahydrobenzofurans.
Applied Organometallic Chemistry,
Journal Year:
2019,
Volume and Issue:
33(6)
Published: April 29, 2019
In
the
current
study,
a
novel
and
reusable
biological
urea
based
nano
magnetic
catalyst
namely
Fe
3
O
4
@SiO
2
@(CH
)
‐urea‐benzimidazole
sulfonic
acid
was
designed
synthesized.
The
structure
of
titled
fully
characterized
using
several
skills
including
Fourier
transform
infrared
(FT‐IR)
spectroscopy,
energy
dispersive
X‐ray
(EDX)
analysis,
diffraction
(XRD),
scanning
electron
microscopy
(SEM),
transmission
(TEM),
thermo
gravimetric
analysis/differential
thermal
analysis
(TG/DTG)
vibrating
sample
magnetometer
(VSM).
Then,
catalytic
performance
successfully
inspected
towards
multicomponent
synthesis
2‐amino‐3‐cyano
pyridine
derivatives
through
vinylogous
anomeric
oxidation
pathway.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
An
operationally
easy
and
atom-economical
approach
for
the
regioselective
tandem
synthesis
of
functionalized
4-aminocarbazoles
from
easily
accessible
2-alkynyl
indole-3-carbonitriles
under
mild
reaction
conditions
has
been
developed.
The
developed
chemistry
involves
aza-Henry
successive
annulation
to
afford
carbazoles.
Replacement
nitromethane
with
acetophenone
led
formation
corresponding
amino(phenyl)methanone-substituted
carbazoles,
further
extending
diversity
chemistry.
methodology
accommodates
wide
functional
group
variation
on
alkyne
is
successfully
applied
late-stage
modification
bioactive
molecules.
Organic Letters,
Journal Year:
2018,
Volume and Issue:
20(18), P. 5648 - 5652
Published: Sept. 4, 2018
An
efficient
synthesis
of
highly
π-extended
carbazoles
is
described
via
an
unexpected
domino
[5
+
3
1]
annulation
approach.
The
Cu(I)-/base-promoted
reactions
2-nitrocinnamaldehydes
with
benzyl
cyanides
provide
diverse
benzo[b]carbazoles.
reaction
proposed
to
proceed
a
sequential
Michael
addition/intramolecular
addition
enol
into
nitro
group,
6π-
electrocyclization,
and
the
final
oxidative
aromatization
as
supported
by
density
functional
theory
calculations.
Some
synthesized
showed
significant
potential
in
fluorescence
sensing
Cu2+
ions.
Organic Letters,
Journal Year:
2019,
Volume and Issue:
21(10), P. 3687 - 3691
Published: April 30, 2019
A
metal-free
strategy
for
the
synthesis
of
benzocarbazoles
from
2-arylindoles
and
aryl
ketones
is
developed.
Various
2-aryl-3-vinyl-indoles
were
generated
in
situ
through
dehydrative
condensation
indoles.
These
key
intermediates
could
be
selectively
converted
into
corresponding
benzo[a]carbazoles
via
a
direct
cyclization
process
between
two
Csp2–H
bonds.
Furthermore,
terminal
alkynes
also
used
as
versatile
C2
source
to
afford
products
good
yields.
ChemCatChem,
Journal Year:
2019,
Volume and Issue:
11(17), P. 4403 - 4410
Published: June 19, 2019
Abstract
Dipolar
and
aprotic
solvents
are
often
required
in
acid‐catalyzed
reactions,
however,
many
of
them
listed
solvent
selection
guides
as
not‐recommended
due
to
their
toxicity
or
explosivity.
A
catalytically
functionalized
ionic
liquid,
namely
a
sulfone‐containing
imidazolium‐based
Brønsted
acid
was
synthesized.
It
alleviates
the
detrimental
effect
classical
dipolar
because
this
liquid
integrates
function
able
stabilize
carbocation
intermediates
activating
strong
on
electrophiles.
The
use
tailor‐made
exemplified
some
transformation
reactions
indoles,
which
proceeded
with
high
yield
selectivity
using
green
an
industrially
acceptable
solvent,
butyl
acetate.
recyclability
catalyst
also
demonstrated.
