The Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
84(16), P. 10449 - 10458
Published: July 23, 2019
By
altering
the
amount
of
Selectfluor,
highly
selective
mono-
and
difluorination
1,3-dicarbonyl
compounds
has
been
achieved,
affording
a
variety
2-fluoro-
2,2-difluoro-1,3-dicarbonyl
in
good
to
excellent
yields.
The
reaction
can
be
readily
performed
aqueous
media
without
any
catalyst
base,
which
features
practical
convenient
fluorination.
Importantly,
gram-scale
reaction,
transformation
2-fluoro-1,3-diphenylpropane-1,3-dione
4-fluoro-1,3,5-triphenyl-1H-pyrazole,
chlorination
bromination
are
realized
further
exhibit
its
synthetic
utility.
Organic Letters,
Journal Year:
2020,
Volume and Issue:
23(2), P. 519 - 524
Published: Dec. 31, 2020
A
simple
and
practical
photochemical
strategy
for
intermolecular
perfluoroalkyl-alkenylation
of
alkenes
with
2-amino-1,4-naphthoquinones
perfluoroalkyl
iodides
has
been
demonstrated
under
visible-light
irradiation.
Mechanistic
studies
reveal
that
easily
available
2-amino-1,4-naphthoquinone
substrates
can
serve
as
efficient
photosensitizers
to
activate
through
a
photoredox
process.
Therefore,
the
developed
radical
relay
reaction
proceeds
smoothly
without
additional
transition
metals
photocatalysts.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(17), P. 4708 - 4715
Published: Jan. 1, 2024
A
simple
and
practical
visible
light-driven
photoredox-catalyzed
three-component
carbotrifluoromethylation
of
alkenes
is
revealed
for
the
synthesis
1,4-bis(trifluoromethylated)
compounds.
Advanced Synthesis & Catalysis,
Journal Year:
2019,
Volume and Issue:
361(12), P. 2945 - 2950
Published: March 28, 2019
Abstract
An
operationally
simple
radical
difluoroalkylation/trifluoromethylation
and
alkynylation
of
unactivated
alkenes
under
mild
conditions
has
been
developed.
Through
this
protocol,
a
series
CF
2
/CF
3
‐
substituted
linear
alkynyl
ketones
were
synthesized
via
unique
1,2‐alkynyl
migration.
Notably,
no
transition‐
metal
catalyst
is
needed
in
the
developed
reaction
system,
excellent
functional
group
compatibility
was
observed.
magnified
image
European Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
2019(34), P. 5998 - 6002
Published: July 31, 2019
By
taking
the
advantage
of
PPh
3
/Selectfluor
system,
carboxylic
acids
are
efficiently
converted
into
pivotal
intermediates
acyloxyphosphonium
ions
that
can
selectively
react
with
a
second
acid
or
fluoride
to
in
situ
yield
corresponding
anhydrides
acyl
fluorides.
The
developed
protocol
features
commercially
availabile
reagents,
no
involvement
base,
room
temperature
conditions,
and
simple
experimental
procedure.
Additionally,
various
amides
esters
readily
achieved,
respectively,
addition
amines
alcohols.
The Journal of Organic Chemistry,
Journal Year:
2019,
Volume and Issue:
84(16), P. 10449 - 10458
Published: July 23, 2019
By
altering
the
amount
of
Selectfluor,
highly
selective
mono-
and
difluorination
1,3-dicarbonyl
compounds
has
been
achieved,
affording
a
variety
2-fluoro-
2,2-difluoro-1,3-dicarbonyl
in
good
to
excellent
yields.
The
reaction
can
be
readily
performed
aqueous
media
without
any
catalyst
base,
which
features
practical
convenient
fluorination.
Importantly,
gram-scale
reaction,
transformation
2-fluoro-1,3-diphenylpropane-1,3-dione
4-fluoro-1,3,5-triphenyl-1H-pyrazole,
chlorination
bromination
are
realized
further
exhibit
its
synthetic
utility.
