An Intramolecular Minisci Reaction in Aqueous Media Using Langlois’ Reagent

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

A trifluoromethylpyridylation of unactivated alkenes in aqueous solution under open air is reported. This process allows the incorporation trifluoromethyl and construction pyridines annulated to saturated cycles via an intramolecular Minisci reaction using Langlois' reagent (CF3SO2Na) as a source. Extrusion from not required. broad functional group tolerance observed. series five-, six-, seven-membered are obtained, exhibiting great potential application preparation diversified pyridines.

Language: Английский

Photoredox-Catalyzed Synthesis of 3,3-Difluoro-γ-lactams via 1,5-Hydrogen Atom Transfer-Involved Alkyne Difunctionalization and C–N Cleavage

Organic Letters, Journal Year: 2024, Volume and Issue: 26(46), P. 9903 - 9908

Published: Nov. 8, 2024

This manuscript describes the application of a 1,5-hydrogen atom transfer strategy in photoredox-catalyzed hydrodifluoroalkylation alkynes. The approach utilizes sequential cascade process difluoroalkylation, transfer, C(sp

Language: Английский

Visible light-driven and substrate-promoted alkenyltrifluoromethylation of alkenes to synthesize CF3-functionalized 1,4-naphthoquinones

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The first example of the visible light-driven and substrate-promoted three-component alkenyltrifluoromethylation alkenes is developed. This approach uses easily available alkenes, 2-arylamino-1,4-naphthoquinones Togni reagent as reactants, describes good functionality tolerance. reaction offers a precise synthesis valuable CF

Language: Английский