The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(14), P. 9835 - 9842
Published: July 11, 2023
Efficient
synthesis
of
phenylalanine-derived
oxazoles
and
imidazolidones
can
be
achieved
by
copper-catalyzed
reactions
that
are
controlled
directing
groups
proceed
selective
C-O
or
C-N
coupling.
This
strategy
employs
inexpensive
commercial
copper
catalysts
readily
available
starting
materials.
It
uses
a
convenient
reaction
procedure
provides
reliable
approach
to
the
versatile
flexible
assembly
heterocyclic
building
blocks.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(10), P. 4094 - 4120
Published: Jan. 1, 2022
This
review
explores
and
summarises
synthetic
methods
that
may
be
used
to
prepare
heterocyclic
ring
systems
from
non-activated
ketones,
considers
their
potential
value
towards
the
synthesis
of
natural
product-inspired
compound
collections.
Heterocyclic Communications,
Journal Year:
2024,
Volume and Issue:
30(1)
Published: Jan. 1, 2024
Abstract
Imidazole
and
its
derivatives
possess
remarkable
versatility,
finding
applications
in
medicine,
synthetic
chemistry,
industry.
This
review
explores
the
latest
advancements
observed
over
last
few
years
(2018–2022),
focusing
on
diverse
multicomponent
reactions
conducted
under
different
conditions.
It
highlights
role
of
catalysts
conditions,
optimizing
efficiency.
The
offers
concise
insights
into
emerging
trends,
making
it
a
valuable
resource
for
researchers
practitioners
seeking
greener
more
efficient
imidazole
synthesis.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(4), P. 1060 - 1065
Published: Jan. 26, 2022
The
first
example
of
divergent
N-heterocycle
syntheses
through
a
copper-catalyzed
three-component
reaction
α,β-unsaturated
ketoximes,
paraformaldehyde,
and
amines
has
been
documented.
In
particular,
this
synthetic
strategy
was
achieved
by
controlling
the
conditions
to
afford
corresponding
imidazoles
dihydroimidazoles
in
moderate
good
yields
with
broad
substrate
scope
functional
group
compatibility.
ChemistrySelect,
Journal Year:
2020,
Volume and Issue:
5(33), P. 10298 - 10328
Published: Sept. 3, 2020
Abstract
p
‐tosylmethyl
isocyanide
(TosMIC)
which
is
also
known
as
van
Leusen's
reagent
hold
the
three
functionalized
groups
including
and
sulfonyl
group
an
alpha
carbon
acidic
by
nature.
Tosyl
set
of
this
fortunate
acts
a
good
leaving
assist
to
contribute
in
range
cyclization
strategies.
Exceptionally,
TosMIC
was
proved
sulfonylating
sulfomethylating
reagent.
has
powerful
versatile
synthon
betrothed
synthesis
broad
heterocycles
having
pharmacological
interest.
This
review
focused
on
synthetic
utility
diverse
like
five
membered
heterocycles,
fused
linked
or
tethered
spiro
compounds
etc
.
It
utilized
for
regio,
chemo
stereoselective
production
sulfones
sulfinates.
serves
important
building
block
various
methodologies
multi
component
reaction,
cyclization,
domino,
cascade
cycloaddition
metal
catalysed
reactions.
Various
new
catalyst
novel
were
explored
due
enormous
use
wonderful
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2142 - 2164
Published: Jan. 17, 2024
Abstract
N‐Heterocyclic
compounds,
in
particular,
quinolines
and
quinazolines
are
frequently
used
medicinal
chemistry.
Therefore,
the
direct
clean
synthesis
of
these
valuable
scaffolds
has
been
a
great
interest
for
many
years.
2‐Aminobenzyl
alcohols
as
an
alternative
reactant
instead
unstable
expensive
2‐aminobenzaldehydes
can
be
construction
N‐fused
heterocycles
including
quinolines,
quinazolines,
oxazines,
thiazines,
selenazines,
imidazoles,
diazepines,
etc.
In
this
review
article,
we
have
discussed
recent
developments
use
2‐aminobenzyl
diverse
heterocycles.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(3)
Published: Jan. 17, 2024
Abstract
Organic
synthesis
involves
the
production
of
important
chemical
structures
using
scalable
and
cost‐effective
methods
that
are
also
environmentally
friendly.
In
this
review,
a
detailed
analysis
use
iodine
DMSO
in
various
synthetic
routes
for
preparation
valuable
targets
presented.
These
reduce
acceptance
on
expensive
additives
reagents,
offer
more
sustainable
solution
these
scaffolds.
Chemical Communications,
Journal Year:
2020,
Volume and Issue:
56(45), P. 6106 - 6109
Published: Jan. 1, 2020
A
facile
synthesis
of
imidazoles
and
tetrazoles
via
[3+1+1]
type
cyclization
ClCF2COONa
is
developed.
diverse
array
were
obtained
in
decent
yields
isocyanide
intermediates.
Notably,
this
the
first
example
cycloaddition
situ
generated
isocyanides.
