The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(14), P. 9835 - 9842
Published: July 11, 2023
Efficient
synthesis
of
phenylalanine-derived
oxazoles
and
imidazolidones
can
be
achieved
by
copper-catalyzed
reactions
that
are
controlled
directing
groups
proceed
selective
C-O
or
C-N
coupling.
This
strategy
employs
inexpensive
commercial
copper
catalysts
readily
available
starting
materials.
It
uses
a
convenient
reaction
procedure
provides
reliable
approach
to
the
versatile
flexible
assembly
heterocyclic
building
blocks.
Organic Letters,
Journal Year:
2020,
Volume and Issue:
22(15), P. 5931 - 5935
Published: July 14, 2020
In
this
work,
a
palladium-catalyzed
[2
+
2
1]
cyclization
of
internal
alkynes
with
double
isocyanides
is
described.
This
facile
procedure
efficient
for
synthesizing
various
pyrrolo[3,2-c]quinolin-2-amines.
The
reaction
worked
well
broad
scope.
the
process,
it
believed
that
sequential
isocyanide
insertion,
6-exo-dig
alkyne,
and
addition
an
imino
group
are
involved.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2020,
Volume and Issue:
8(45), P. 16946 - 16951
Published: Nov. 4, 2020
A
green
and
efficient
procedure
for
the
preparation
of
valuable
2,3-dihydrofurans
benzoxazines
has
been
achieved
through
halocyclization
olefinic
1,3-dicarbonyls
or
amides.
This
protocol
could
be
conducted
under
catalyst-,
base-,
oxidant-free
conditions
in
aqueous
media
open
to
air
at
room
temperature
with
good
excellent
yields.
Notably,
practicality
this
method
is
further
highlighted
by
gram-scale
reactions
New Journal of Chemistry,
Journal Year:
2021,
Volume and Issue:
45(44), P. 20486 - 20518
Published: Jan. 1, 2021
The
preparation
of
heterocyclic
compounds
has
attracted
great
attention
in
organic
chemistry
because
their
extensive
application
the
field
bioactive
molecules,
materials
science,
and
natural
products.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(56), P. 7180 - 7183
Published: Jan. 1, 2024
A
novel
process
using
N
-benzylhydroxylamine
hydrochloride
as
a
“C1N1
synthon”
in
[2+2+1]
cyclization
for
the
construction
of
1,2,5-trisubstituted
imidazoles
has
been
described
first
time.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
9(5), P. 1403 - 1409
Published: Jan. 1, 2022
An
I
2
-mediated
[3
+
2]
annulation
to
access
fused
imidazoles
from
methyl-azaarenes
and
alkyl
2-isocyanoacetates
was
developed.
This
method
can
be
used
for
the
structural
modification
of
natural
products,
gram
scale
reactions
further
transformations.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(23), P. 5958 - 5964
Published: Jan. 1, 2023
A
novel
[3
+
1
1]
cyclization
reaction
for
the
synthesis
of
compounds
based
on
a
5-cyano-1
H
-pyrazolo[3,4-
b
]pyridine
skeleton
from
aryl
methyl
ketones,
malononitrile
and
5-aminopyrazoles
has
been
established.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(24), P. 16204 - 16212
Published: Nov. 22, 2022
An
iodine-promoted
domino
reaction
of
aurones
with
amidines
has
been
successfully
explored.
The
proceeds
in
a
consecutive
manner
containing
Michael
addition,
iodination,
cyclization
from
intramolecular
nucleophilic
substitution,
and
dehydrogenative
aromatization
spiro
ring
opening.
Following
this
novel
strategy,
variety
1,2,4-trisubstituted
5-(o-hydroxybenzoyl)imidazoles
were
efficiently
synthesized
moderate
to
good
yields
readily
available
starting
materials.
A
plausible
mechanism
proposed.
