SSRN Electronic Journal,
Journal Year:
2022,
Volume and Issue:
unknown
Published: Jan. 1, 2022
Through
the
hydrothermal
reaction
of
cobalt(II)
perchlorate
hexahydrate
with
5-bromo-6-methyl-pyridine-2-carboxylic
acid
(5-Br-6-Me-Hpyc)
and
1,4-bis(4-pyridyl)benzene
(1,4-bpb)
coligands,
one
complex
[Co(5-Br-6-Me-pyc)
2
(H
O)]·2H
O
(
1
)
organic-inorganic
adduct
[H
(1,4-bpb)]·2ClO
4
have
been
co-synthesized
in
same
medium.
Structural
analysis
indicates
that
ion
is
penta-coordinated
by
water
two
bidentate
chelate
5-Br-6-Me-pyc
anionic
ligands
to
obtain
an
asymmetric
mononuclear
species.
While
,
pyridyl
groups
1,4-bpb
get
protons
forming
a
bivalent
cation
pyridinium,
which
combine
anions
via
N–H⋯O
hydrogen
bonds
fabricate
interesting
anion-cation
supramolecular
.
The
magnetism
for
fluorescence
as
well
hirshfeld
surface
structures
them
carefully
described
discussed.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(1), P. 370 - 370
Published: Jan. 2, 2023
Each
metabolite,
regardless
of
its
molecular
simplicity
or
complexity,
has
a
mission
function
in
the
organism
biosynthesizing
it.
In
this
review,
biological,
allelochemical,
and
chemical
properties
acetophenone,
as
metabolite
involved
multiple
interactions
with
various
(mi-cro)organisms,
are
discussed.
Further,
details
biogenesis
synthesis
provided,
possibility
application
different
areas
life
sciences,
i.e.,
status
quo
acetophenone
simple
substituted
analogs,
is
examined.
particular,
natural
synthetic
derivatives
analyzed
promising
agrochemicals
useful
scaffolds
for
drug
research
development.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(11), P. 2557 - 2564
Published: March 22, 2024
Abstract
An
iodine/DMSO‐promoted
approach
has
been
developed
for
the
synthesis
of
indoloquinolines
via
a
sequential
sp
3
C−H
oxidation/intramolecular
cyclization
using
2‐(1
H
‐indol‐2‐yl)anilines
and
aryl
methyl
ketones.
A
wide
range
ketones,
including
drugs
complex
bioactive
molecule‐derived
substrates
were
compatible
in
present
reaction
with
yields
30–96%.
This
protocol
proceeds
through
oxidation
ketones
to
phenylglyoxals,
subsequent
imine
formation,
furnish
indoloquinolines.
Further,
is
applicable
gram‐scale
operationally
simple.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(17), P. 12783 - 12791
Published: Aug. 16, 2023
A
novel
transition
metal-free
strategy
for
the
synthesis
of
benzene-fused
β-carboline
scaffolds
has
been
developed.
This
protocol
offers
a
rapid
and
direct
pathway
to
access
benzene
fused
from
2-(1H-indol-3-ylsulfanyl)-phenylamines
aryl
methyl
ketones
using
an
efficient
catalytic
system
I2/DMSO.
The
present
mild
proceeds
through
sequential
reactions
Kornblum
oxidation,
Pictet-Spengler
cyclization,
desulfurization
afford
desired
products
in
excellent
yields
up
99%.
Moreover,
this
method
wide
range
substrate
tolerance
is
operationally
simple
applicable
gram-scale
synthesis.
Catalysts,
Journal Year:
2023,
Volume and Issue:
13(1), P. 87 - 87
Published: Jan. 1, 2023
Ruthenium
complexes
are
remarkable
catalysts
for
the
C–H
activation
approaches
and
organic
transformations.
Combining
a
Ru-catalyst
with
oxidants
other
additives
in
one-pot
process
is
considered
sustainable
approach
due
to
reduction
reaction
steps
minimal
usage
of
solvents
during
synthesis,
work-up,
isolation
chemicals,
purification
products.
This
review
highlights
ruthenium-catalyzed
transformations
manner
achieve
heterocyclic
backbones,
including
indoles,
benzofurans,
indazoles,
pyrans,
pyrimidines,
quinolines,
isoquinolines.
SynOpen,
Journal Year:
2022,
Volume and Issue:
06(02), P. 110 - 131
Published: April 14, 2022
The
synthesis
of
aromatic
heterocycles
has
attracted
substantial
attention
due
to
the
abundance
these
in
drug
molecules,
natural
products,
and
other
compounds
biological
interest.
Accordingly,
there
is
a
demand
for
straightforward
synthetic
protocols
toward
such
using
readily
available
starting
materials.
In
past
decade,
have
been
developments
heterocycle
synthesis,
especially
metal-catalyzed
iodine-assisted
approaches.
This
graphical
review
focuses
on
notable
reactions
from
decade
aryl
heteroaryl
methyl
ketones
as
materials,
including
representative
reaction
mechanisms.
