Recent advances in microfluidic technology of arterial thrombosis investigations DOI Creative Commons

Jingying Lin,

Si Chen,

Chunying Zhang

et al.

Platelets, Journal Year: 2024, Volume and Issue: 35(1)

Published: Feb. 23, 2024

Microfluidic technology has emerged as a powerful tool in studying arterial thrombosis, allowing researchers to construct artificial blood vessels and replicate the hemodynamics of flow. This led significant advancements understanding thrombosis platelet adhesion aggregation. models have various types functions, by fabrication methods working principles microfluidic chips, applicable can be selected according specific needs. The rapid development integrated system modular makes research more diversified automated, but its standardization still needs solved urgently. One key advantage is ability precisely control fluid flow microchannels analyze behavior under different shear forces rates. allows study physiological pathological processes flow, shedding light on underlying mechanisms thrombosis. In conclusion, revolutionized enabling construction accurately reproducing hemodynamics. future, microfluidics will place greater emphasis versatility automation, holding great promise for advancing antithrombotic therapeutic prophylactic measures.

Language: Английский

Cancer-on-chip: a 3D model for the study of the tumor microenvironment DOI Creative Commons

Elisa Cauli,

Michela Anna Polidoro, Simona Marzorati

et al.

Journal of Biological Engineering, Journal Year: 2023, Volume and Issue: 17(1)

Published: Aug. 17, 2023

Abstract The approval of anticancer therapeutic strategies is still slowed down by the lack models able to faithfully reproduce in vivo cancer physiology. On one hand, conventional vitro fail recapitulate organ and tissue structures, fluid flows, mechanical stimuli characterizing human body compartments. other animal cannot typical tumor microenvironment, essential study behavior progression. This reviews cancer-on-chips as most promising tools model investigate microenvironment metastasis. We also described how cancer-on-chip devices have been developed implemented common primary cancers their metastatic sites. Pros cons this technology are then discussed highlighting future challenges close gap between pre-clinical clinical studies accelerate new therapies humans.

Language: Английский

Citations

22
Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques DOI Creative Commons
Hui Wang, Xiangyang Li, Pengcheng Shi

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101079 - 101079

Published: May 5, 2024

As a booming engineering technology, the microfluidic chip has been widely applied for replicating complexity of human intestinal micro-physiological ecosystems in vitro. Biosensors, 3D imaging, and multi-omics have to engineer more sophisticated barrier-on-chip platforms, allowing improved monitoring physiological processes enhancing performance. In this review, we report cutting-edge advances techniques establishment evaluation barrier platforms. We discuss different design principles microfabrication strategies gut models Further, comprehensively cover complex cell types (e.g., epithelium, organoids, endothelium, microbes, immune cells) controllable extracellular microenvironment parameters oxygen gradient, peristalsis, bioflow, gut-organ axis) used recapitulate main structural functional barriers. also present current multidisciplinary technologies indicators evaluating morphological structure integrity established Finally, highlight challenges future perspectives accelerating broader applications these platforms disease simulation, drug development, personalized medicine. Hence, review provides comprehensive guide development microfluidic-based

Language: Английский

Citations

8
Tailoring biomaterials for biomimetic organs-on-chips DOI
Lingyu Sun, Feika Bian, Dongyu Xu

et al.

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(11), P. 4724 - 4745

Published: Jan. 1, 2023

The advances in biomaterials for the construction of organs-on-chips are reviewed, including design, fabrication, functions, applications, and future directions these biomaterial-based platforms.

Language: Английский

Citations

15
Emergence of integrated biosensing-enabled digital healthcare devices DOI Creative Commons
Anshuman Mishra, Pravin Kumar Singh, Nidhi Chauhan

et al.

Sensors & Diagnostics, Journal Year: 2024, Volume and Issue: 3(5), P. 718 - 744

Published: Jan. 1, 2024

Digital biosensors facilitate real-time, remote, precise disease detection and biochemical analysis.

Language: Английский

Citations

6
Recent advances in microfluidic technology of arterial thrombosis investigations DOI Creative Commons

Jingying Lin,

Si Chen,

Chunying Zhang

et al.

Platelets, Journal Year: 2024, Volume and Issue: 35(1)

Published: Feb. 23, 2024

Microfluidic technology has emerged as a powerful tool in studying arterial thrombosis, allowing researchers to construct artificial blood vessels and replicate the hemodynamics of flow. This led significant advancements understanding thrombosis platelet adhesion aggregation. models have various types functions, by fabrication methods working principles microfluidic chips, applicable can be selected according specific needs. The rapid development integrated system modular makes research more diversified automated, but its standardization still needs solved urgently. One key advantage is ability precisely control fluid flow microchannels analyze behavior under different shear forces rates. allows study physiological pathological processes flow, shedding light on underlying mechanisms thrombosis. In conclusion, revolutionized enabling construction accurately reproducing hemodynamics. future, microfluidics will place greater emphasis versatility automation, holding great promise for advancing antithrombotic therapeutic prophylactic measures.

Language: Английский

Citations

5