Small Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Lung
cancer
cells
resistant
to
radiotherapy
present
a
significant
clinical
challenge.
Stable
telomeric
structures,
maintained
by
the
TRF2
protein,
play
critical
role
in
protecting
from
ionizing
radiation.
Reduced
expression
increases
DNA
damage
and
radiosensitivity.
We
designed
self‐assembling
system
utilizing
ultra‐small
luminescent
gold
nanoclusters
(AuNCs)
with
radiosensitizing
properties,
combined
siRNA
targeting
TRF2.
The
forms
≈100
nm
non‐spherical
structures
AuNCs
enriched
outer
layer,
exhibiting
17.6‐fold
enhancement
red
photoluminescence
due
aggregation‐induced
effects.
This
nanoplatform
efficiently
penetrates
lung
cells,
reducing
50%.
Under
5
Gy
radiotherapy,
treated
this
show
1.5‐fold
radiosensitivity
increase
2.3‐fold
reduction
clonogenic
survival
telomere
deprotection.
AuNC‐siRNATRF2
combines
enhanced
optical
properties
biological
functionality,
offering
promising
approach
augment
efficacy
disrupting
protective
mechanisms
cells.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(3), P. 89 - 89
Published: March 5, 2025
Background:
Fluorescent
gold
nanoclusters
conjugated
with
α-lipoic
acid
(FANCs)
have
shown
great
promise
for
drug
development.
In
a
previous
study,
FANCs
did
not
show
any
acute
or
subacute
toxicity
under
0.6–20
μM/100
μL/25
g
body
weight
in
male
and
female
ICR
mice.
However,
the
chronic
of
has
been
studied.
Aim
study:
This
study
used
oral
administration
to
determine
long-term
safety
profile
adverse
effects
Methods:
vivo
was
examined
via
The
daily
food
consumption,
weight,
hematological
profile,
serum
biochemical
organ
coefficient,
histopathological
changes,
survival
rate
mice
were
calculated.
Results:
result
mortality
due
both
animal
behavior,
coefficient
showed
no
treatment-related
malignant
changes.
indicates
that
do
cause
liver,
renal,
other
damage.
Conclusions:
These
results
indicate
no-observed-adverse-effect
level
(NOAEL)
is
20
6
months
treatment
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: May 6, 2025
Gold
nanoparticles
(AuNPs)
possess
unique
properties,
including
low
toxicity
and
excellent
optical
characteristics,
making
them
highly
appealing
for
biomedical
applications.
The
plasmonic
photothermal
effect
of
AuNPs
has
been
explored
to
trigger
localized
hyperthermia.
Four
commonly
gold
(spheres,
rods,
stars,
cages)
are
produced
optimized
present
the
surface
plasmon
resonance
in
near-infrared
region,
exploiting
increased
penetration
human
body.
Additionally,
production
hybrid
AuNPs,
combining
with
other
materials,
such
as
silica,
graphene,
zinc
oxide,
polymers,
small
molecules
amplify
(T
≥
45ºC).
This
review
provides
an
overview
AuNPs'
application
therapy,
describing
general
synthesis
processes
main
particle
parameters
that
affect
their
nanomaterials.
Associated
this
rapid
progress,
functionalization
can
also
improve
colloidal
stability,
safety,
therapeutic
outcomes.
In
regard,
we
highlight
emerging
trend
applying
cell-derived
vesicles
biomimetic
coatings,
capable
evading
immune
recognition,
increasing
blood
circulation,
targeting
specific
tissues.
addition,
challenges
future
developments
accelerating
clinical
translations
discussed
light
theragnostic
potential.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(17), P. 4283 - 4300
Published: Jan. 1, 2024
The
advancement
of
gold
nanoclusters
(Au
NCs)
has
given
rise
to
a
new
era
in
fabricating
functional
materials
due
their
controllable
morphology,
stable
optical
properties,
and
excellent
biocompatibility.
Assemblies
based
on
Au
NCs
demonstrate
significant
potentiality
constructing
multiple
structures
as
acceptable
agents
applications
such
sensing,
imaging
technology,
drug
delivery
systems.
In
addition,
the
assembled
strategies
illustrate
integration
mechanism
between
each
component
while
facing
material
requirement.
It
is
necessary
provide
supplementary
comprehensive
reviews
(based
NCs),
which
hold
promise
for
could
expand
range
potential
applications.
This
review
focuses
combination
with
metals,
metal
oxides,
non-metal
materials,
are
intricately
arranged
through
various
interaction
forces
including
covalent
bonds
coordination,
resulting
diverse
array
multifunctional
NC
assemblies.
These
assemblies
have
widespread
fields
biological
imaging,
delivery,
devices.
concludes
by
highlighting
challenges
future
prospects
assemblies,
emphasizing
importance
continued
research
advance
nanomaterial
assembly
innovation.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(7), P. 1537 - 1537
Published: March 29, 2024
A
wide
range
of
nano-objects
is
found
in
many
applications
our
everyday
life.
Recognition
their
peculiar
properties
and
ease
functionalization
has
prompted
engineering
into
multifunctional
platforms
that
are
supposed
to
afford
efficient
tools
for
the
development
biomedical
applications.
However,
bridging
gap
between
bench
bedside
cannot
be
expected
without
a
good
knowledge
behaviour
vivo,
which
can
obtained
through
non-invasive
imaging
techniques,
such
as
positron
emission
tomography
(PET).
Their
radiolabelling
with
[18F]-fluorine,
technique
already
well
established
widely
used
routinely
PET
imaging,
[18F]-FDG
example,
preclinical
investigation
using
[18F]-radiolabelled
biological
macromolecules,
has,
therefore,
been
developed.
In
this
context,
review
highlights
various
studied
so
far,
reasons
behind
radiolabelling,
main
vitro
and/or
vivo
results
thereof.
Then,
methods
developed
introduce
radioelement
presented.
Detailed
indications
on
chemical
steps
involved
provided,
stability
discussed.
Emphasis
then
made
techniques
purify
analyse
radiolabelled
nano-objects,
point
rarely
discussed
despite
its
technical
relevance
importance
accurate
imaging.
The
pros
cons
different
finally
from
future
work
develop.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(3), P. 378 - 378
Published: Jan. 30, 2024
Metalloenzymes
are
able
to
catalyze
complex
biochemical
reactions
in
cellular
(aqueous)
media
with
high
efficiency.
In
recent
years,
a
variety
of
metal-containing
single-chain
nanoparticles
(SCNPs)
have
been
synthesized
as
simplified
metalloenzyme-mimetic
nano-objects.
However,
most
the
SCNPs
reported
so
far
contained
complexed
metal
ions
but
not
nanoclusters
(NCs)
diameter
<5
nm,
which
could
be
used
powerful,
emerging
catalysts.
Herein,
we
report
synthesis
gold
(Au-NCs)
within
and
further
use
Au-NCs/SCNPs
catalytic
nanoreactors
water.
We
demonstrate
that
common
motif
several
drugs
(i.e.,
aminophenyl–oxazolidinone
fragment
present
Rivaroxaban,
Sutezolid,
Linezolid)
can
efficiently
prepared
water
from
hydrophobic
precursor
compound
by
using
efficient
nanoreactors.
summary,
this
work
paves
way
forthe
metal–NCs/SCNPs
for
advanced
catalysis
aqueous
media.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(32)
Published: May 16, 2024
Abstract
Gold
nanoclusters
exhibiting
concomitant
photothermy
(PT)
and
photoluminescence
(PL)
under
near‐infrared
(NIR)
light
irradiation
are
rarely
reported,
some
fundamental
issues
remain
unresolved
for
such
materials.
Herein,
we
concurrently
synthesized
two
novel
rod‐shaped
Au
nanoclusters,
52
(PET)
32
66
38
(PET
=
2‐phenylethanethiolate),
precisely
revealed
that
their
kernels
were
4
×
6
5
face‐centered
cubic
(fcc)
structures,
respectively,
based
on
the
numbers
of
layers
in
[100],
[010],
[001]
directions.
Following
structural
growth
mode
from
to
,
predicted
six
more
nanoclusters.
The
concurrent
synthesis
provides
rational
comparison
stability,
absorption,
emission
photothermy,
reveals
aspect
ratio‐related
properties.
An
interesting
finding
is
exhibit
PT
PL
785
nm
irradiation,
balance,
which
was
explained
by
qualitative
evaluation
radiative
non‐radiative
rates.
ligand
effects
also
investigated.
