International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139281 - 139281
Published: Dec. 1, 2024
Language: Английский
Science China Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Spider silk (SPSI) is a promising candidate for use as filler material in nerve guidance conduits (NGCs), facilitating peripheral regeneration by providing scaffold Schwann cells (SCs) and axonal growth. However, the specific properties of SPSI that contribute to its regenerative success remain unclear. In this study, egg sac Trichonephila (T.) inaurata investigated, which contains two distinct fiber types: tubuliform (TU) major ampullate (MA) silk. These fibers serve models derive parameters governing SC migration on natural substrates, since they are produced same spider, yet exhibiting composition morphology. paper, detailed characterization fibers' vitro evaluation their SC-guiding performance were conducted. Live cell imaging revealed significantly enhanced mobility directionality TU compared MA silk, remarkable, given lack studies regeneration. Our results suggest morphological these critical nerve-guiding potential. insights optimization NGC materials identifying key essential effective
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114544 - 114544
Published: Feb. 5, 2025
Language: Английский
Citations
0
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(9), P. 675 - 675
Published: April 29, 2025
Stem cells therapies offer a promising approach in translational oncology, as well regenerative medicine due to the tropism of these damage site. To track distribution stem cells, latter could be labeled by MRI-sensitive superparamagnetic (SPM) iron oxide nanoparticles. In current study, magnetic properties nanoparticles (MNPs) incorporated into bone marrow-derived fetal mesenchymal (FetMSCs) were evaluated employing nonlinear response measurements. Synthesized dextran-coated additionally characterized X-ray diffraction, transmission electron microscopy, and dynamic light scattering. The MNP uptake FetMSCs 24 h following coincubation was studied longitudinal weak alternating field with registration second harmonic magnetization. Subsequent data processing using formalism based on numerical solution Fokker–Planck kinetic equation allowed us determine parameters state MNPs culture medium. It found that formed aggregates medium; they absorbed during coincubation. exhibited SPM regime medium, remained virtually unchanged indicating preservation aggregation inside cells. This implies also organic shell FetMSCs. accumulation gradually increased concentration MNPs. Thus, study confirmed labeling MSCs is an effective method for subsequent cell tracking retain their properties.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(42), P. 56555 - 56579
Published: Oct. 8, 2024
Millions of people worldwide suffer from musculoskeletal damage, thus using the largest proportion rehabilitation services. The limited self-regenerative capacity bone and cartilage tissues necessitates development functional biomaterials. Magnetoactive materials are a promising solution due to clinical safety deep tissue penetration magnetic fields (MFs) without attenuation heating. Herein, electrospun microfibrous scaffolds were developed based on piezoelectric poly(3-hydroxybutyrate) (PHB) composite nanofillers [magnetite with graphene oxide (GO) or reduced GO]. scaffolds' morphology, structure, mechanical properties, surface potential, response systematically investigated. Furthermore, complex mechanism enzymatic biodegradation these is proposed that involves (i) release polymer crystallites, (ii) crystallization amorphous phase, (iii) dissolution phase. Incorporation Fe3O4, Fe3O4–GO, Fe3O4–rGO accelerated PHB owing pores fibers enlarged content phase in scaffolds. Six-month caused reduction potential (1.5-fold) vertical piezoresponse (3.5-fold) Fe3O4–GO scaffold because decrease β-phase content. In vitro assays absence an MF showed significantly more pronounced mesenchymal stem cell proliferation compared neat scaffold, whereas (68 mT, 0.67 Hz), was not statistically different when all studied compared. PHB/Fe3O4–GO implanted into femur defects rats, resulting successful repair after nonperiodic stimulation (200 0.04 Hz) synergetic influence increased roughness, presence hydrophilic groups near surface, magnetoelectric magnetomechanical effects material.
Language: Английский
Citations
3
Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(3), P. 660 - 670
Published: April 16, 2024
Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, communities; the financial costs can be challenging families health institutions. Treatments aimed at restoring spinal after injury, which have been tested animal models or clinical trials, generally seek to counteract one more of mechanisms limit extent initial damage. Most published works on structural/functional restoration acute chronic stages use a single type treatment: drug trophic factor, transplant cell type, implantation biomaterial. Despite significant benefits reported models, when translating these successful therapeutic strategies humans, result trials has considered little relevance because improvement, present, is usually insufficient. Until now, studies designed promote neuroprotection regeneration different used treatments. Considering occurrence various sub-acute phases it reasonable speculate that than agent could required structural functional damaged cord. combine several agents, targeting which, as therapy, shown some benefits, allow us assume they will synergistic beneficial effects. Thus, narrative review article aims summarize current trends agents administered simultaneously sequentially, seeking injured
Language: Английский
Citations
2
Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 3765 - 3790
Published: Aug. 1, 2024
Polydopamine is a versatile and modifiable polymer, known for its excellent biocompatibility adhesiveness. It can also be engineered into variety of nanoparticles biomaterials drug delivery, functional modification, making it an choice to enhance the prevention treatment orthopedic diseases. Currently, application polydopamine in disease early stages, despite some initial achievements. This article aims review these applications encourage further development therapeutic needs. We detail properties biomaterial types, highlighting superior performance modification on materials. Additionally, we explore challenges future prospects developing optimal clinical use treatment.
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(36), P. 48547 - 48555
Published: Aug. 26, 2024
Additive manufacturing (AM) is emerging as an eco-friendly method for minimizing waste, the demand responsive materials in IoT and Industry 4.0 on rise. Magnetoactive composites, which are manufactured through AM, facilitate nonintrusive remote sensing actuation. Printed magnetoelectric composites innovative that utilizes synergies between magnetic electric properties. The study of effects, including recently validated piezoinductive effect, demonstrates generation voltage external AC DC fields. This shift sensors, utilizing effect piezoelectric polymer poly(vinylidene fluoride), PVDF, eliminates need fillers printed devices, aligning with sustainability principles, essential deployment 4.0. achieved sensitivity surpasses other studies by 100 times, showcasing linear outputs both applied Additionally, sensor capitalizes phase generated signal field, unprecedented effect. Thus, this work introduces a remarkable magnetoactive device
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Dec. 19, 2024
Numerous conduits have been developed to improve peripheral nerve regeneration. However, challenges remain, including remote control of conduit function, and programmed cell behaviors like orientation. We synthesized Fe3O4-MnO2@Zirconium-based Metal-organic frameworks@Retinoic acid (FMZMR) core-shell assessed their impact on Schwann function behavior within made from decellularized human umbilical arteries (DHUCA) under magnetic field (MF). FMZMR core-shell, featuring a spherical porous structure catalytic properties, effectively scavenges radicals facilitates controlled drug release MF. The histology the DHUCA indicates effective decellularization with adequate tensile strength Young's modulus for sciatic In-vitro results demonstrate that is biocompatible promotes proliferation through remotely release. Furthermore, its synergy MF enhances orientation increases neurite length by ~ 1.93-fold. Functional histological evaluations indicate combined regeneration, decreases muscle atrophy, new neuron growth myelin formation, without negatively affecting vital tissues. This study suggests synergistic effect can alleviate some treatment challenges.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139281 - 139281
Published: Dec. 1, 2024
Language: Английский
Citations
0