Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2483 - 2483
Published: Oct. 29, 2024
Diabetic foot ulcers (DFUs) are a common and severe complication of diabetic patients, with significant global prevalence associated health burdens, including high recurrence rates, lower-limb amputations, substantial economic costs. This study aimed to understand the user needs healthcare professionals treating for newly developed material technologies.
Language: Английский
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
The skin is fragile, making it very vulnerable to damage and injury. Untreated wounds can pose a serious threat human health. Three-dimensional polymer network hydrogels have broad application prospects in wound dressings due their unique properties structure. therapeutic effect of traditional limited, while multifunctional composite show greater potential. Multifunctional regulate moisture through formula adjustment. Moreover, be combined with bioactive ingredients improve performance healing applications. Stimulus-responsive respond specifically the environment meet needs different stages. This review summarizes material types, structure, properties, design considerations, formulation strategies for hydrogel used healing. We discuss various types recently developed dressings, highlights importance tailoring physicochemical addresses potential challenges preparing dressings.
Language: Английский
Citations
0
Biosensors, Journal Year: 2025, Volume and Issue: 15(3), P. 139 - 139
Published: Feb. 23, 2025
Wound healing is a complicated biological process that important for restoring tissue integrity and function after injury. Infection, usually due to bacterial colonization, significantly complicates this by hindering the course of enhancing chances systemic complications. Recent advances in wearable biosensors have transformed wound care making real-time monitoring biomarkers such as pH, temperature, moisture, infection-related metabolites like trimethylamine uric acid. This review focuses on recent biosensor technologies designed management. Novel sensor architectures, flexible stretchable electronics, colorimetric patches, electrochemical platforms, enable non-invasive detection changes associated with wounds high specificity sensitivity. These are increasingly combined AI analytics based smartphones can timely personalized interventions. Examples PETAL patch applies multiple sensing mechanisms wide-ranging views status closed-loop systems connect therapeutic devices automate infection control. Additionally, self-powered tap into body heat or energy from biofluids themselves avoid any external batteries thus more effective field use limited resources. Internet Things connectivity allows further support remote sharing data, supporting telemedicine applications. Although developed relatively rapidly their prospects continue expand, regular clinical application stalled significant challenges regulatory, cost, patient compliance, technical problems related accuracy, biofouling, power, among others, need be addressed innovative solutions. The goal synthesize current trends, challenges, future directions monitoring, emphasis potential improve outcomes reduce healthcare burdens. innovations leading way toward next-generation bridging advanced materials science, biotechnology, digital health.
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
An effective and rapid hemostatic material with flexible properties for clinical wound dressings is still an unmet need. Herein, a porous sodium carboxymethyl starch (CMS-Na-P) microsphere was successfully fabricated through polysaccharide fluffy aggregate (PSFA) technology facile low-cost process. CMS-Na-P exhibited water absorption capabilities alongside favorable cytocompatibility hemocompatibility. Additionally, could absorb red blood cells (RBCs), adhere to activate platelets, shorten clotting time in vitro. More importantly, its good vivo ability further demonstrated against hemorrhage rat liver tail, pig superficial skin, body vein, abdominal femoral artery. Meanwhile, full-thickness skin defect model, enhance healing accelerated epidermal regeneration collagen deposition. These make promising candidate treating bleeding wounds.
Language: Английский
Citations
0
Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 113(9), P. 2795 - 2807
Published: July 9, 2024
Language: Английский
Citations
3
Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 28, P. 100975 - 100975
Published: Sept. 6, 2024
Language: Английский
Citations
3
Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(3), P. 1965 - 1977
Published: July 5, 2024
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(42), P. 56762 - 56776
Published: Oct. 9, 2024
In clinical practice to treat complex injuries, the application of electrical stimulation (ES) directly skin complicates wound. this work, effect a conductive hydrogel mediated electric field on regeneration is investigated. Polypyrrole incorporated matrices gelatin and silk fibroin were prepared by two-step interfacial polymerization. The maximum conductivity 10–4 S cm–1 was achieved when 200 mM polypyrrole loaded. Mechanically stable cytocompatible hydrogels evidenced have antioxidant blood compatible characteristics. Human dermal fibroblast cells responded pulsed 100 or 300 mV mm–1 as observed from increased expressions TGFβ1, αSMA, COLIAI genes. Further, increase in αSMA protein expression with magnitude also suggested transdifferentiation myofibroblast. Moreover, Raman spectroscopy identified two fingerprint regions (collagen lipid) differentiate ES treated nontreated samples. Therefore, combination has potential therapeutic effects for accelerating rate regeneration.
Language: Английский
Citations
1
International Journal of Experimental Pathology, Journal Year: 2024, Volume and Issue: 105(6), P. 235 - 245
Published: Oct. 22, 2024
Abstract The skin wound model in rats is a fundamental stage preclinical trials, but there lack of standardization these trials regarding the initial area, making analysis and comparison between studies difficult. Therefore, this study evaluates healing progression excisional lesions varying diameters Wistar rats, aiming to identify optimal size for monitoring treatment effects on healing. Excisions 0.8, 1.5, 2.0 3.0 cm diameter were made back animals. Thirty animals used per evaluated days 3, 7, 10, 14 21 after surgery. cleaned daily with saline solution until they completely closed. 0.8 group showed complete repair D14, while other groups, wounds persisted day 21, reddened surface no epidermal coverage, greater keratinization presence appendages 1.5 lesions. as creating wounds, we suggest using or excisions, considering that close very early although behaving similarly are more invasive proved be suitable closure within days. When evaluating product intended accelerate healing, recommended assess effectiveness treatment.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2483 - 2483
Published: Oct. 29, 2024
Diabetic foot ulcers (DFUs) are a common and severe complication of diabetic patients, with significant global prevalence associated health burdens, including high recurrence rates, lower-limb amputations, substantial economic costs. This study aimed to understand the user needs healthcare professionals treating for newly developed material technologies.
Language: Английский
Citations
0