Unlocking Nature’s Potential: Ferritin as a Universal Nanocarrier for Amplified Cancer Therapy Testing via 3D Microtissues DOI Creative Commons

Iqra Munir,

Faiqa Nazir, Gurkan Yesiloz

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

In the existing development of extensive drug screening models, 3D cell cultures outshine conventional 2D monolayer cells by closely imitating in vivo tumor microenvironment. This makes culture a more physiologically relevant and convenient system regime preclinical testing. nanomedicinal world, nanoconjugates as nanocarriers are largely hunted due to their capability precisely binding target distributing essential dosages therapeutic drugs with enhanced safety profiles. Thus, for boosted availability, evolution from treatment combination therapies last switching carriers has gained significant progression cancer cure. contrast engineered nanoparticles, herein, we successfully designed biomolecule (ferritin)-based effective both single (valproic acid-VPA) twin-drug acid/doxorubicin-Dox) carriers, which dramatically enhance proficiency modality. To question reported adjuvant property VPA, progressed utilizing at first VPA alone an yet exclusive therapy when delivered via some carrier molecule, particular protein. Subsequently, paralleled this comprehensive investigation output compare test coloading strategy observe synergistic and/or additive behavior conjugation other anticancer agents (Dox) while given molecule. approach this, Dox molecules were encapsulated into ferritin (F) cavity using thermosensitive synthesis method maintaining temperature 60 °C. The successful encapsulation protein nanocage was confirmed through various characterization techniques. F-VPA/F-VPA-Dox exhibited similar morphology structural characteristics hollow cage showed cytotoxicity than naked tested on spheroid models. Precisely, our nanoconjugate, i.e., F-VPA, offered 3-fold increased intratumoral concentration free significantly suppressed growth after single-dose treatment. However, second modeled viz. F-VPA-Dox, revealed extended median survival period lesser toxicity administered much dose (∼3–5 μM), models lines. All all, importantly, inhibition rate treatment, further confirms benefits active targeting these nanocarriers. Moreover, also offer deliver cells, alongside tremendous biocompatibility profiles numerous

Language: Английский

Exploring the antibacterial, antifungal and anticancer effects of a novel bacteriocin-cerium oxide nanoconjugate DOI

Sana M.H. Al-Shimmary,

Zina Hashem Shehab, Emad Hamdi Jassim

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: 174, P. 113925 - 113925

Published: Jan. 8, 2025

Language: Английский

Citations

0
Highly sensitive benzildihydrazone-N,N'-bis(2-hydroxy-4-diethylamino-1-formylbenzene) stabilized ZnS nanoparticles as potential optical chemosensors for Hg2+ ions: Anticancer activity and biosensor imaging DOI

Vanshika Sharma,

Srishti Dutta,

Rajat Roy

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141398 - 141398

Published: Jan. 1, 2025

Language: Английский

Citations

0
Unlocking Nature’s Potential: Ferritin as a Universal Nanocarrier for Amplified Cancer Therapy Testing via 3D Microtissues DOI Creative Commons

Iqra Munir,

Faiqa Nazir, Gurkan Yesiloz

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

In the existing development of extensive drug screening models, 3D cell cultures outshine conventional 2D monolayer cells by closely imitating in vivo tumor microenvironment. This makes culture a more physiologically relevant and convenient system regime preclinical testing. nanomedicinal world, nanoconjugates as nanocarriers are largely hunted due to their capability precisely binding target distributing essential dosages therapeutic drugs with enhanced safety profiles. Thus, for boosted availability, evolution from treatment combination therapies last switching carriers has gained significant progression cancer cure. contrast engineered nanoparticles, herein, we successfully designed biomolecule (ferritin)-based effective both single (valproic acid-VPA) twin-drug acid/doxorubicin-Dox) carriers, which dramatically enhance proficiency modality. To question reported adjuvant property VPA, progressed utilizing at first VPA alone an yet exclusive therapy when delivered via some carrier molecule, particular protein. Subsequently, paralleled this comprehensive investigation output compare test coloading strategy observe synergistic and/or additive behavior conjugation other anticancer agents (Dox) while given molecule. approach this, Dox molecules were encapsulated into ferritin (F) cavity using thermosensitive synthesis method maintaining temperature 60 °C. The successful encapsulation protein nanocage was confirmed through various characterization techniques. F-VPA/F-VPA-Dox exhibited similar morphology structural characteristics hollow cage showed cytotoxicity than naked tested on spheroid models. Precisely, our nanoconjugate, i.e., F-VPA, offered 3-fold increased intratumoral concentration free significantly suppressed growth after single-dose treatment. However, second modeled viz. F-VPA-Dox, revealed extended median survival period lesser toxicity administered much dose (∼3–5 μM), models lines. All all, importantly, inhibition rate treatment, further confirms benefits active targeting these nanocarriers. Moreover, also offer deliver cells, alongside tremendous biocompatibility profiles numerous

Language: Английский

Citations

0