Battery-free and AI-enabled multiplexed sensor patches for wound monitoring

Science Advances, Journal Year: 2023, Volume and Issue: 9(24)

Published: June 16, 2023

Wound healing is a dynamic process with multiple phases. Rapid profiling and quantitative characterization of inflammation infection remain challenging. We report paper-like battery-free in situ AI-enabled multiplexed (PETAL) sensor for holistic wound assessment by leveraging deep learning algorithms. This consists wax-printed paper panel five colorimetric sensors temperature, pH, trimethylamine, uric acid, moisture. Sensor images captured mobile phone were analyzed neural network–based machine algorithms to determine status. For ex detection via exudates collected from rat perturbed wounds burn wounds, the PETAL can classify versus nonhealing status an accuracy as high 97%. With patches attached on models, monitoring progression or severity demonstrated. allows early warning adverse events, which could trigger immediate clinical intervention facilitate care management.

Language: Английский

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Surface-engineered prussian blue nanozymes as artificial receptors for universal pattern recognition of metal ions and proteins

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 390, P. 134006 - 134006

Published: May 22, 2023

Language: Английский

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Nanozyme colorimetric sensor array based on monatomic cobalt for the discrimination of sulfur-containing metal salts

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 456, P. 131643 - 131643

Published: May 15, 2023

Language: Английский

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Machine learning-assisted optical nano-sensor arrays in microorganism analysis

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 159, P. 116945 - 116945

Published: Jan. 20, 2023

Language: Английский

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Colorimetric sensing for translational applications: from colorants to mechanisms

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7681 - 7741

Published: Jan. 1, 2024

This review summarizes insights into colorant selection and signal mechanisms for the development of colorimetric sensing POC sensors.

Language: Английский

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Multi-signal sensor array based on a fluorescent nanozyme for broad-spectrum screening of pesticides

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148784 - 148784

Published: Jan. 17, 2024

Language: Английский

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Construction and Application of Nanozyme Sensor Arrays

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(21), P. 8221 - 8233

Published: May 13, 2024

Compared with traditional "lock–key mode" biosensors, a sensor array consists of series sensing elements based on intermolecular interactions (typically hydrogen bonds, van der Waals forces, and electrostatic interactions). At the same time, arrays also have advantages fast response, high sensitivity, low energy consumption, cost, rich output signals, imageability, which attracted widespread attention from researchers. Nanozymes are nanomaterials own enzyme-like properties. Because adjustable activity, stability, cost effectiveness nanozymes, they potential candidates for construction to different signals analytes through chemoresponse colorants, solves shortcomings sensors that cannot support multiple detection lack universality. Recently, nanozymes as nonspecific recognition receptors has much more researchers been applied precise proteins, bacteria, heavy metals. In this perspective, is given regulation their activity. Particularly, building principles methods analyzed, applications summarized. Finally, approaches overcome challenges perspectives presented analyzed facilitating further research development nanozyme arrays. This perspective should be helpful gaining insight into ideas within field

Language: Английский

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Dual-Emission Single Sensing Element-Assembled Fluorescent Sensor Arrays for the Rapid Discrimination of Multiple Surfactants in Environments

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(12), P. 4987 - 4996

Published: March 11, 2024

Surfactants are considered as typical emerging pollutants, their extensive use of in disinfectants has hugely threatened the ecosystem and human health, particularly during pandemic coronavirus disease-19 (COVID-19), whereas rapid discrimination multiple surfactants environments is still a great challenge. Herein, we designed fluorescent sensor array based on luminescent metal–organic frameworks (UiO-66-NH2@Au NCs) for specific six (AOS, SDS, SDSO, MES, SDBS, Tween-20). Wherein, UiO-66-NH2@Au NCs were fabricated by integrating UiO-66-NH2 (2-aminoterephthalic acid-anchored-MOFs zirconium ions) with gold nanoclusters (Au NCs), which exhibited dual-emission features, showing good luminescence. Interestingly, due to interactions NCs, can differentially regulate fluorescence property producing diverse "fingerprints", further identified pattern recognition methods. The proposed achieved 100% accuracy identifying various multicomponent mixtures, detection limit range 0.0032 0.0315 mM was successfully employed real environmental waters. More importantly, our findings provided new avenue surfactants, rendering promising technique monitoring against trace multicontaminants.

Language: Английский

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Metal-based nanomaterials with enzyme-like characteristics for bacterial rapid detection and control

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215799 - 215799

Published: April 1, 2024

Language: Английский

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Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.

Language: Английский

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