Nanotechnology,
Journal Year:
2024,
Volume and Issue:
36(4), P. 045101 - 045101
Published: Oct. 30, 2024
Abstract
The
tumor
microenvironment
(TME)
is
characterized
by
low
pH,
hypoxia,
and
overexpression
of
glutathione
(GSH).
Owing
to
the
complexity
pathogenesis
heterogeneity
TME,
achieving
satisfactory
efficacy
with
a
single
treatment
method
difficult,
which
significantly
impedes
treatment.
In
this
study,
composite
nanoparticles
calcium-copper/alginate-hyaluronic
acid
(HA)
(CaO
2
-CuO
@SA/HA
NC)
pH
GSH
responsiveness
were
prepared
for
first
time
through
one-step
synthesis
using
HA
as
targeting
ligand.
Nanoparticles
loaded
H
O
can
enhance
chemodynamic
therapy
effects.
Simultaneously,
Cu
2+
generate
oxygen
in
TME
alleviate
hypoxia
tissue.
undergo
Fenton
reaction
produce
cytotoxic
hydroxyl
radicals
Ca
ions,
localization
clearance
cells.
Additionally,
sodium
alginate
(SA)
utilized
improve
biocompatibility
nanoparticles.
Fourier
transform
infrared,
x-ray
diffraction,
dynamic
light
scattering,
SEM,
transmission
electron
microscope,
other
analytical
methods
used
investigate
their
physical
chemical
properties.
results
indicate
that
CaO
NC
had
particle
size
220
nm,
narrow
distribution,
uniform
morphology.
hydrogen
peroxide
self-supplied
nanodrug
delivery
system
exhibited
excellent
pH-responsive
release
performance
glutathione-responsive
•OH
ability
while
also
reducing
level
reactive
oxide
species
quenching.
vitro
cell
experiments,
no
obvious
side
effects
on
normal
tissues
observed;
however,
inhibition
rate
malignant
tumors
HepG2
DU145
exceeded
50%.
preparation
nanoparticles,
achieve
both
chemokinetic
ion
interference
therapy,
has
demonstrated
significant
potential
clinical
applications
cancer
therapy.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 13, 2024
Abstract
Cascade
reactions
are
described
as
efficient
and
versatile
tools,
organized
catalytic
cascades
can
significantly
improve
the
efficiency
of
chemical
interworking
between
nanozymes.
They
have
attracted
great
interest
in
many
fields
such
chromogenic
detection,
biosensing,
tumor
diagnosis,
therapy.
However,
how
to
selectively
kill
cells
by
enzymatic
without
harming
normal
cells,
well
exploring
two
or
more
enzyme‐engineered
nanoreactors
for
cascading
reactions,
remain
challenges
field
targeted
specific
cancer
diagnostics
The
latest
research
advances
nanozyme‐catalyzed
cascade
processes
diagnosis
therapy
this
article.
Here,
various
sensing
strategies
summarized,
tumor‐specific
diagnostics.
Targeting
mechanisms
treatment
using
nanozymes
classified
analyzed,
“elements”
“dimensions”
nanozymes,
types,
designs
structure,
assembly
modes
highly
active
a
variety
new
targeting
based
on
reaction
Finally,
integrated
application
systems
tumor‐targeted
diagnostic
is
which
will
lay
foundation
design
rational,
efficient,
therapeutic
modalities
future.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(21), P. 25437 - 25451
Published: May 18, 2023
Traditional
treatments
for
hepatocellular
carcinoma
(HCC)
still
lack
effectiveness.
Recently,
the
combined
mode
of
chemodynamic
therapy
(CDT)
and
photothermal
(PTT)
has
shown
great
potential
against
HCC.
However,
insufficient
Fenton
reaction
rates
hyperthermia-induced
heat
shock
responses
greatly
impair
their
efficiency,
hindering
further
clinical
application.
Here,
we
constructed
a
cascade-amplified
PTT/CDT
nanoplatform
by
coating
an
IR780-embedded
red
blood
cell
membrane
on
glucose
oxidase
(GOx)-loaded
Fe3O4
nanoparticles
effective
HCC
treatment.
On
one
hand,
interfered
with
metabolism
through
action
GOx
to
reduce
synthesis
ATP,
which
reduced
expression
proteins,
thereby
sensitizing
IR780-mediated
PTT.
other
hydrogen
peroxide
generated
during
catalysis
thermal
effect
PTT
accelerated
Fe3O4-mediated
reaction,
realizing
enhanced
CDT.
Consequently,
sensitized
CDT
management
could
be
simultaneously
achieved
interfering
metabolism,
providing
alternative
strategy
treatment
tumors.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 22, 2024
The
development
of
nanoassemblies,
activated
by
the
tumor
microenvironment,
capable
generating
photothermal
therapy
(PTT)
and
amplifying
"ROS
(·OH)
storm,"
is
essential
for
precise
effective
synergistic
treatment.
Herein,
an
innovative
cascade-amplified
nanotheranostics
based
on
biodegradable
Pd-BSA-GOx
nanocomposite
NIR-II
photoacoustic
imaging
(PAI)
guides
self-enhanced
PTT/chemodynamic
(CDT)/starvation
therapy.
demonstrates
ability
to
selectively
convert
overexpressed
H
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(32), P. 38309 - 38322
Published: Aug. 3, 2023
The
development
of
tumor
microenvironment
(TME)-activated
nanoassemblies
which
can
produce
a
photoacoustic
(PA)
signal
and
enhance
the
H2O2
level
is
critical
to
achieve
accurate
diagnosis
highly
efficient
chemodynamic
therapy
(CDT).
In
this
study,
we
developed
consisting
oxygen
vacancy
titanium
dioxide
(TiO2–x)
surface-constructed
copper,
sulfur-doped
mesoporous
organosilica
glucose
oxidase
(TiO2–x@Cu,S-MONs@GOx,
hereafter
TMG).
We
found
that
abundant
glutathione
(GSH)
in
TME
reduce
tetrasulfide
bonds
Cu2+
sulfur
ions
Cu+
TMG
nanoassemblies,
respectively,
causing
breakage
bond
structure
collapse,
releasing
TiO2–x
nanoparticles,
producing
hydrogen
sulfide
gas,
thereby
achieving
synergistic
multimodal
treatment
through
TME-activated
NIR-II
PA
imaging
photothermal-enhanced
gas
starvation-primed
CDT.
Therefore,
form
smart
nanoplatform
serve
as
an
excellent
diagnosis-treatment
agent
by
playing
important
role
imaging-guided
precision
cancer
targeting
treatment.
