Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 20, 2025
Salmonella
is
one
of
the
most
common
foodborne
pathogens,
which
can
cause
severe
enteritis
and
intestinal
microbiota
imbalance.
However,
there
are
limited
strategies
currently
available
for
preventing
or
treating
Salmonella-induced
colitis.
Herein,
we
developed
Cu/Mn-co-doped
ZnO
tandem
nanozyme
(ZnO-CM)
with
pH-responsive
multienzyme-mimicking
activities
via
doping
engineering
treatment
Benefiting
from
co-doping
Cu
Mn,
ZnO-CM
nanospheres
exhibit
remarkable
peroxidase-like
activity
in
acidic
condition
superoxide
dismutase-
catalase-like
neutral
environment.
Animal
experiments
show
that
efficiently
inhibit
bacterial
growth,
alleviate
inflammation,
restore
barrier,
resulting
good
antibacterial
anti-inflammatory
effects
on
Mechanistically,
functions
through
inhibiting
continuous
accumulation
ROS,
increasing
levels
tight
junction
proteins
occludin
claudin-1,
decreasing
expression
pro-inflammatory
cytokines
IL-1β
IL-6
intestine.
This
work
not
only
presents
an
effective
paradigm
colitis
therapy,
but
also
provides
new
sights
into
prevention
other
enteritis.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: March 20, 2024
Diabetic
wounds
are
susceptible
to
bacterial
infections,
largely
linked
high
blood
glucose
levels
(hyperglycemia).
To
treat
such
wounds,
enzymes
like
oxidase
(GOx)
can
be
combined
with
nanozymes
(nanomaterials
mimic
enzymes)
use
effectively
for
purposes.
However,
there
is
still
room
improvement
in
these
systems,
particularly
terms
of
process
simplification,
enzyme
activity
regulation,
and
treatment
effects.
Herein,
the
approach
utilizes
GOx
directly
facilitate
biomineralized
growth
osmium
(Os)
nanozyme
(GOx-OsNCs),
leading
dual-active
centers
remarkable
triple
activities.
Initially,
GOx-OsNCs
vicinal
centers,
enabling
a
self-cascaded
mechanism
that
significantly
enhances
sensing
performance
compared
step-by-step
reactions,
surpassing
capabilities
other
metal
sources
as
gold
platinum.
In
addition,
integrated
into
glucose-sensing
gel,
instantaneous
visual
feedback.
infected
diabetic
exhibit
multifaceted
benefits
by
lowering
exhibiting
antibacterial
properties
through
generation
hydroxyl
free
radicals,
thereby
expediting
healing
fostering
favorable
microenvironment.
Furthermore,
catalase-like
aids
reducing
oxidative
stress,
inflammation,
hypoxia,
culminating
improved
outcomes.
Overall,
this
synergistic
enzyme-nanozyme
blend
user-friendly
holds
considerable
promise
diverse
applications.
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
The
rising
prevalence
of
diabetes
has
underscored
concerns
surrounding
diabetic
wounds
and
their
potential
to
induce
disability.
intricate
healing
mechanisms
are
multifaceted,
influenced
by
ambient
microenvironment,
including
prolonged
hyperglycemia,
severe
infection,
inflammation,
elevated
levels
reactive
oxygen
species
(ROS),
ischemia,
impaired
vascularization,
altered
wound
physicochemical
properties.
In
recent
years,
hydrogels
have
emerged
as
promising
candidates
for
treatment
owing
exceptional
biocompatibility
resemblance
the
extracellular
matrix
(ECM)
through
a
three-dimensional
(3D)
porous
network.
This
review
will
first
summarize
microenvironment
alterations
occurring
in
wounds,
aiming
provide
comprehensive
understanding
its
pathogenesis,
then
classification
recently
developed
be
presented,
encompassing
properties
such
hypoglycemic
effects,
anti-inflammatory
capabilities,
antibacterial
attributes,
ROS
scavenging
abilities,
promotion
angiogenesis,
pH
responsiveness,
more.
primary
objective
is
offer
valuable
reference
repairing
based
on
unique
microenvironment.
Moreover,
this
paper
outlines
avenues
future
advancements
hydrogel
dressings
facilitate
expedite
process
wounds.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
16(1), P. 95 - 110
Published: Dec. 29, 2023
Nanozymes,
emerging
nanomaterials
for
wound
healing,
exhibit
enzyme-like
activity
to
modulate
the
levels
of
reactive
oxygen
species
(ROS)
at
sites.
Yet,
solo
regulation
endogenous
ROS
by
nanozymes
often
falls
short,
particularly
in
chronic
refractory
wounds
with
complex
and
variable
pathological
microenvironments.
In
this
study,
we
report
development
a
multifunctional
dressing
integrating
conventional
alginate
(Alg)
hydrogel
newly
developed
biodegradable
copper
hydrogen
phosphate
(CuP)
nanozyme,
which
possesses
good
near-infrared
(NIR)
photothermal
conversion
capabilities,
sustained
Cu
ion
release
ability,
pH-responsive
peroxidase/catalase-mimetic
catalytic
activity.
When
examining
acute
infected
characterized
low
pH
environment,
engineered
Alg/CuP
composite
hydrogels
demonstrated
high
bacterial
eradication
efficacy
against
both
planktonic
bacteria
biofilms,
attributed
combined
action
catalytically
generated
hydroxyl
radicals
ions.
contrast,
when
applied
diabetic
wounds,
typically
have
these
significant
angiogenic
performance.
This
is
driven
provision
dissolved
beneficial
supplement
ions
released
from
degradable
CuP
nanozyme.
Further,
mild
thermal
effect
induced
NIR
irradiation
amplifies
activities
bioactivity
ions,
thereby
enhancing
healing
process
wounds.
Our
study
validates
that
synergistic
integration
effects,
activity,
can
concurrently
yield
antibacterial
efficiency
tissue
regenerative
rendering
it
highly
promising
various
clinical
applications
healing.
