Chemistry - An Asian Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 22, 2025
Abstract
Cathepsin
S
(CatS)
is
a
lysosomal
enzyme
belonging
to
the
papain
family
of
cysteine
proteases.
Studies
have
demonstrated
that
CatS
plays
pivotal
role
in
antigen
presentation
and
associated
with
Alzheimer's
disease,
atherosclerosis,
obesity,
positioning
it
as
potential
target
related
disorders.
Consequently,
development
selective
straightforward
method
for
detecting
crucial.
In
this
study,
we
introduce
colorimetric
approach
utilizing
gold
nanoparticles
(AuNPs)
CatS‐specific
peptides
detection
activity.
The
cleavage
peptides,
PMGAPC
or
PMGAPC‐NH
2
,
can
stabilize
AuNPs
hydrosaline
solution
without
aggregation.
Upon
hydrolysis
by
CatS,
aggregate
color
change
from
red
blue.
After
optimizing
size
concentration
limits
were
both
be
10
nM,
when
used
protect
AuNPs.
Therefore,
assay,
which
employs
AuNPs,
enables
not
only
but
also
simple
visible
naked
eye.
Sensors,
Journal Year:
2024,
Volume and Issue:
24(2), P. 431 - 431
Published: Jan. 10, 2024
Industrial
development
has
led
to
the
widespread
production
of
toxic
materials,
including
carcinogenic,
mutagenic,
and
chemicals.
Even
with
strict
management
control
measures,
such
materials
still
pose
threats
human
health.
Therefore,
convenient
chemical
sensors
are
required
for
monitoring,
as
optical,
electrochemical,
nanomaterial-based,
biological-system-based
sensors.
Many
existing
new
have
been
developed,
well
methods
based
on
novel
technologies
detecting
materials.
The
emergence
material
sciences
advanced
fabrication
signal-transducing
processes
substantial
improvements
in
sensing
elements
target
recognition
reporting
interactions
between
targets
elements.
excellent
reviews
effectively
summarized
general
principles
applications
different
types
this
review
focuses
sensor
advancements
terms
elements,
more
recent
achievements
detection.
We
also
discuss
trends
biosensors
detection
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(4), P. 3011 - 3022
Published: Jan. 18, 2024
The
divergent
supramolecular
behavior
of
a
series
tripeptide
stereoisomers
was
elucidated
through
spectroscopic,
microscopic,
crystallographic,
and
computational
techniques.
Only
two
epimers
were
able
to
effectively
self-organize
into
amphipathic
structures,
leading
hydrogels
or
crystals,
respectively.
Despite
the
similarity
between
peptides'
turn
conformations,
stereoconfiguration
led
different
abilities
engage
in
intramolecular
hydrogen
bonding.
Self-assembly
further
shifted
pKa
value
C-terminal
side
chain.
As
result,
across
pH
range
4–6,
only
one
epimer
predominated
sufficiently
as
zwitterion
reach
critical
molar
fraction,
allowing
gelation.
By
contrast,
differing
values
higher
dipole
moment
other
favored
crystallization.
four
tested
for
gold
nanoparticle
(AuNP)
formation,
with
hydrogel
being
key
control
stabilize
AuNPs,
yielding
nanocomposite
that
catalyzed
photodegradation
dye.
Importantly,
AuNP
formation
occurred
without
use
reductants
than
peptide,
redox
chemistry
investigated
by
LC–MS,
NMR,
infrared
scattering-type
near
field
optical
microscopy
(IR
s-SNOM).
This
study
provides
important
insights
rational
design
simple
peptides
minimalistic
green
building
blocks
functional
nanocomposites.
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
