Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(11)

Published: Dec. 12, 2023

Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance

Language: Английский

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Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215907 - 215907

Published: May 12, 2024

Language: Английский

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

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A multifunctional nanoaggregate‐based system for detection of rheumatoid arthritis via Optoacoustic/NIR‐II fluorescent imaging and therapy via inhibiting JAK‐STAT/NF‐κB/NLRP3 pathways

Aggregate, Journal Year: 2023, Volume and Issue: 5(1)

Published: Sept. 11, 2023

Abstract Rheumatoid arthritis (RA) is a debilitating autoimmune disease that causes chronic pain and serious complications, presenting significant challenge to treat. Promising approaches for treating RA involve signaling pathways modulation targeted therapy. To this end, multifunctional nanosystem, TPC‐U@HAT, has been designed therapy, featuring multitargeting, dual‐stimuli response, on‐demand drug release capabilities. TPC‐U@HAT composed of probe/prodrug TPC, JAK1 kinase inhibitor upadacitinib, the carrier HAT. TPC an aggregation‐induced emission (AIE)‐active NIR‐II chromophore TPY NF‐κB/NLRP3 caffeic acid phenethyl ester (CAPE), connected via boronic bond which serves as reactive‐oxygen‐species‐responsive linker. The carrier, HAT, created by grafting bone‐targeting alendronate hydrophobic tocopheryl succinate onto hyaluronic chains, can encapsulate upadacitinib form TPC‐U@HAT. Upon intravenous injection into mice, accumulates at inflamed lesions through both active passive targeting, overexpressed hyaluronidase H 2 O therein cleave polymer chains boronate bonds, respectively. This generates AIE‐active detection therapeutic evaluation optoacoustic imaging fluorescent concomitantly releases CAPE exert efficacious therapy inhibiting JAK‐STAT pathways.

Language: Английский

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Precisely Constructing Renal-Clearable and LAP-Activatable Ratiometric Molecular Probes for Early Diagnosis of Acute and Chronic Kidney Injury Via Optimizing Asymmetric DPP Dyes

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 96(1), P. 272 - 280

Published: Dec. 22, 2023

Fluorescence analysis is an increasingly important contributor to the early diagnosis of kidney diseases. To achieve precise visualization kidneys and related diseases, asymmetric pyrrolopyrrolidone (DPP) dye platform with C-aromatic substituents N-lipophilic/hydrophilic modification was constructed. Based on these, we developed renal-clearable, water-soluble, injury biomarker leucine aminopeptidase (LAP) activated ratiometric fluorescent probe DPP-S-L. In mouse model cisplatin-induced acute during development type 2 diabetes diabetic disease, visualized for first time upregulation LAP in urine by dual-channel fluorescence signal diagnosed earlier more sensitively than blood/urine enzyme detection tissue analysis. This study showcases excellent DPP renal-clearable design strategy that extended determination other biomarkers disease diagnosis.

Language: Английский

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Kidney-Targeted Near-Infrared Fluorescence Probe Reveals That SO₂ Is a Biomarker for Cisplatin-Induced Acute Kidney Injury

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(34), P. 12948 - 12955

Published: Aug. 17, 2023

With the widespread use of drugs, drug-induced acute kidney injury (AKI) has become an increasingly serious health concern worldwide. Currently, early diagnosis AKI remains challenging because lack effective biomarkers and noninvasive imaging tools. SO2 plays important physiological roles in living systems is antioxidant for maintaining redox homeostasis. However, relationship between (in water as SO32-/HSO3-) largely unknown. Herein, we report highly sensitive near-infrared fluorescence probe DSMN, which first time reveals AKI. The responds to SO32-/HSO3- selectively rapidly (within seconds) shows a significant turn-on at 710 nm with large Stokes shift (125 nm). these properties, was successfully applied detect cells mice. Importantly, can target kidneys, allowing detection changes concentration kidneys. Based on this, DSMN used cisplatin-induced revealed increase levels. results indicate that new biomarker powerful tool studying diagnosing

Language: Английский

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NIR-II Fluorescence Imaging for In Vivo Quantitative Analysis

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(22), P. 28011 - 28028

Published: May 24, 2024

In vivo real-time qualitative and quantitative analysis is essential for the diagnosis treatment of diseases such as tumors. Near-infrared-II (NIR-II, 1000-1700 nm) bioimaging an emerging visualization modality based on fluorescent materials. The advantages NIR-II region materials in terms reduced photon scattering low tissue autofluorescence enable with high resolution increasing depth penetration, thus have great potential analysis. this review, we first summarize recent advances imaging, including probe selection, strategies, imaging. Then, describe detail representative applications to illustrate how fluorescence imaging has become important tool Finally, future possibilities challenges

Language: Английский

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Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing

Angewandte Chemie, Journal Year: 2023, Volume and Issue: 136(11)

Published: Dec. 12, 2023

Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance

Language: Английский

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Tailored Zwitterionic Hemicyanine Reporters for Early Diagnosis and Prognostic Assessment of Acute Renal Failure

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(52)

Published: Nov. 11, 2023

Drug-induced renal failure (DIRF) poses a serious medical complication with high mortality risk. However, early diagnosis or prognosis of DIRF remain challenging, as current methods rely on detecting late-stage biomarkers. Herein we present library zwitterionic unimolecular hemicyanines (ZCs) available for constructing activatable reporters to detect since its initial stage. Zwitterionic properties these probes are achieved through interspersedly integrating alkyl sulfonates and quaternary ammonium cations onto hemicyanine skeleton, which result in record low plasma protein binding (<5 %) remarkable clearance efficiencies (≈96 %). An reporter ZCRR is further developed by masking the optimal candidate ZC6 tetrapeptide specifically cleavable caspase-8, an initiating indicator apoptosis. In living mice cisplatin-induced DIRF, systematically administered efficiently accumulates kidneys responds elevated caspase-8 near-infrared fluorescence signals 'turn-on', enabling sensitive detection intrarenal apoptosis 60 h earlier than clinical methods, precise evaluation remediation effects different medications mice. As it's urinary excretable, also allows remote predicting renoprotective efficacy vitro optical urinalysis. This study thus presents clearable scaffolds that applicable developing versatile diseases management.

Language: Английский

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Bifunctional ratiometric fluorescent membrane containing pyrene-based probe for visual monitoring and efficient removal of Al3+

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 413, P. 135860 - 135860

Published: April 21, 2024

Language: Английский

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