Self-Augmented Reactive Oxygen Species-Responsive Nanoformulation with Efficient Curcumin Delivery for Inhibiting Triple-Negative Breast Cancer Cell Growth and Migration DOI Creative Commons
Kangkang Li, Siyuan Wang, Xiaoxia Jiang

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(9), P. 5516 - 5529

Published: April 24, 2024

Triple-negative breast cancer (TNBC) remains the second most-life-threatening carcinoma to women worldwide. Compared conventional chemotherapeutic drugs, natural compounds, especially curcumin (CUR), have been proven therapeutical potential in TNBC treatment. To improve accumulation of CUR at tumor sites, a reactive oxygen species (ROS)-responsive nanocarrier was developed (CUR@Bio/PE-NPs) with entrapment and biotin conjugation, exhibiting strong affinity for cells. CUR@Bio/PE-NPs demonstrated particle size 142.9 nm, good stability, an encapsulation efficiency 63.67%, while realizing positive feedback loop ROS-accelerated release CUR-induced ROS generation In vitro studies revealed that induced effectively promoted ∼1.30- 1.36-fold cellular uptake Nile red@Bio/PE-NPs compared nontargeted nanoparticles MDA-MB-231 4T1 cells, respectively. addition, suppressed their proliferation (IC50, MDA-MB-231:3.277 μg/mL, 4T1:5.259 μg/mL) increased apoptosis cell cycle arrest preventing cell-migration invasion. Importantly, xenografted mice model, nanoformulation prolonged modulated immune microenvironment prevented growth lung metastases without significant toxicity. short, vivo results suggested as promising strategy therapy.

Language: Английский

Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy DOI
Junjie Zhang, Jiani Zhou, Longguang Tang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(35)

Published: April 23, 2024

Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles tumor diagnosis treatment lie their ability to target delivery, minimizing toxicity normal tissues while enhancing therapeutic efficacy. Moreover, responsiveness both endogenous exogenous stimuli opens up new possibilities integrating multiple modalities. This review scrutinizes the burgeoning utility combination with chemotherapy other Commencing elucidation synthesis degradation mechanisms, emphasis placed on these materials (e.g., pH, redox reactions, hypoxia, enzymes) light high-intensity focused ultrasound). this exploration delves into strategies harnessing alone, coupled radiotherapy, photothermal therapy, photodynamic gas immunotherapy, starvation chemodynamic elucidating multimodal synergies. Concluding an assessment advances, challenges, constraints oncology, despite hurdles, future investigations are anticipated augment role cancer therapy. These insights can serve a compass devising more efficacious combined strategies.

Language: Английский

Citations

11
Biomimetic Trypsin-Responsive Structure-Bridged Mesoporous Organosilica Nanomedicine for Precise Treatment of Acute Pancreatitis DOI
Yanan Wang,

Deyao Qian,

Xinyuan Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 19283 - 19302

Published: July 11, 2024

Developing strategies to target injured pancreatic acinar cells (PACs) in conjunction with primary pathophysiology-specific pharmacological therapy presents a challenge the management of acute pancreatitis (AP). We designed and synthesized trypsin-cleavable organosilica precursor bridged by arginine-based amide bonds, leveraging trypsin's ability selectively identify guanidino groups on arginine via Asp189 at active S1 pocket cleave carboxy-terminal (C-terminal) bond catalytic triads. The precursors were incorporated into framework mesoporous silica nanoparticles (MSNs) for encapsulating membrane-permeable Ca

Language: Английский

Citations

10
Glutathione-responsive polypeptide nanogel encapsulates Shikonin for breast cancer therapy DOI
Siqi Li,

Qingshuang Wang,

Zhilin Li

et al.

Nanomedicine Nanotechnology Biology and Medicine, Journal Year: 2025, Volume and Issue: 64, P. 102802 - 102802

Published: Jan. 7, 2025

Language: Английский

Citations

1
Recent Advances in Silica-Based Nanomaterials for Enhanced Tumor Imaging and Therapy DOI
Junjie Zhang, Zilu Liu, Zhijing Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7133 - 7169

Published: Nov. 4, 2024

Cancer remains a formidable challenge, inflicting profound physical, psychological, and financial burdens on patients. In this context, silica-based nanomaterials have garnered significant attention for their potential in tumor imaging therapy owing to exceptional properties, such as biocompatibility, customizable porosity, versatile functionalization capabilities. This review meticulously examines the latest advancements application of therapy. It underscores enhancing various cancer modalities, including fluorescence imaging, magnetic resonance computed tomography, positron emission ultrasound multimodal approaches. Moreover, delves into therapeutic efficacy chemotherapy, radiotherapy, phototherapy, immunotherapy, gas therapy, sonodynamic chemodynamic starvation gene Critical evaluations biosafety profiles degradation pathways these within biological environments are also presented. By discussing current challenges prospects, aims provide nuanced perspective clinical translation nanomaterials, thereby highlighting promise revolutionizing diagnostics, enabling real-time monitoring responses, advancing personalized medicine.

Language: Английский

Citations

4
Magnesium-ion-doped silica nanosheets as degradable drug carriers with enhanced antibacterial activity and cellular uptake DOI Creative Commons

Ruohan Liao,

Chengdong Zhang,

Z.G Wang

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3183 - 3191

Published: Jan. 1, 2025

The synthesis of degradable magnesium-ion-doped silica nanosheets (MgMSNs) that exhibit antibacterial activity and cellular uptake capability positions them as promising candidates for drug delivery systems.

Language: Английский

Citations

0
Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy DOI
Junjie Zhang, Haiyang Guo, Longguang Tang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216540 - 216540

Published: Feb. 27, 2025

Language: Английский

Citations

0
Artesunate loaded core-shell nanoplatform for the chemo-chemodynamic-photothermal synergistic cancer therapy DOI

Z.H. Gan,

Chang Liu, Shaopeng Li

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 254, P. 114810 - 114810

Published: May 17, 2025

Language: Английский

Citations

0
Nanostructured mesoporous silica carriers for platinum-based conjugates with anti-inflammatory agents DOI Creative Commons
Ivana Predarska, Goran N. Kaluđerović, Evamarie Hey‐Hawkins

et al.

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 165, P. 213998 - 213998

Published: Aug. 19, 2024

This review discusses the relationship between inflammation and cancer initiation progression, which has prompted research into anti-inflammatory approaches for prevention treatment. Specifically, it focuses on use of inflammation-reducing agents to enhance effectiveness tumor treatment methods. These are combined with platinum(II)-based antitumor drugs create multifunctional platinum(IV) prodrugs, allowing simultaneous delivery cells in a specific ratio. Once inside subjected intracellular reduction, both components can act parallel through distinct pathways. Motivated by objective reducing systemic toxicity associated contemporary chemotherapy, aim leveraging passive enhanced permeability retention effect exhibited nanostructured materials improve their accumulation within tissues, complexes have been efficiently loaded mesoporous silica SBA-15 material. The resulting capable providing controlled release conjugates when simulated plasma conditions. feature suggests potential extended circulation body vivo, minimal premature drug before reaching intended target site. primary emphasis this is that integrates these two develop chemotherapeutic treatments more efficient less harmful.

Language: Английский

Citations

1
Gadolinium ion-loaded mesoporous organosilica nanoplatform for enhanced radiotherapy in breast tumor treatment DOI
Junjie Zhang, Lu Li, Wenqing Zhang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 246, P. 114374 - 114374

Published: Nov. 13, 2024

Language: Английский

Citations

1
Self-Augmented Reactive Oxygen Species-Responsive Nanoformulation with Efficient Curcumin Delivery for Inhibiting Triple-Negative Breast Cancer Cell Growth and Migration DOI Creative Commons
Kangkang Li, Siyuan Wang, Xiaoxia Jiang

et al.

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: 6(9), P. 5516 - 5529

Published: April 24, 2024

Triple-negative breast cancer (TNBC) remains the second most-life-threatening carcinoma to women worldwide. Compared conventional chemotherapeutic drugs, natural compounds, especially curcumin (CUR), have been proven therapeutical potential in TNBC treatment. To improve accumulation of CUR at tumor sites, a reactive oxygen species (ROS)-responsive nanocarrier was developed (CUR@Bio/PE-NPs) with entrapment and biotin conjugation, exhibiting strong affinity for cells. CUR@Bio/PE-NPs demonstrated particle size 142.9 nm, good stability, an encapsulation efficiency 63.67%, while realizing positive feedback loop ROS-accelerated release CUR-induced ROS generation In vitro studies revealed that induced effectively promoted ∼1.30- 1.36-fold cellular uptake Nile red@Bio/PE-NPs compared nontargeted nanoparticles MDA-MB-231 4T1 cells, respectively. addition, suppressed their proliferation (IC50, MDA-MB-231:3.277 μg/mL, 4T1:5.259 μg/mL) increased apoptosis cell cycle arrest preventing cell-migration invasion. Importantly, xenografted mice model, nanoformulation prolonged modulated immune microenvironment prevented growth lung metastases without significant toxicity. short, vivo results suggested as promising strategy therapy.

Language: Английский

Citations

0