Sulfated Chitosan-Modified CuS Nanocluster: A Versatile Nanoformulation for Simultaneous Antibacterial and Bone Regenerative Therapy in Periodontitis

ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14312 - 14326

Published: May 20, 2024

Periodontitis, a prevalent chronic inflammatory disease worldwide, is triggered by periodontopathogenic bacteria, resulting in the progressive destruction of periodontal tissue, particularly alveolar bone. To effectively address periodontitis, this study proposed nanoformulation known as CuS@MSN-SCS. This formulation involves coating citrate-grafted copper sulfide (CuS) nanoparticles with mesoporous silica (MSNs), followed surface modification using amino groups and sulfated chitosan (SCS) through electrostatic interactions. The objective to achieve efficient bacteria removal inducing ROS signaling pathways mediated Cu2+ ions. Additionally, it aims promote bone regeneration Cu2+-induced pro-angiogenesis SCS-mediated regeneration. As anticipated, regulating charges, negatively charged CuS capped sodium citrate were successfully coated MSNs, subsequent introduction amine (3-aminopropyl)triethoxysilane was incorporation SCS interactions, formation developed verified not only significantly exacerbate oxidative stress Fusobacterium nucleatum, thereby suppressing growth biofilm vitro, but also alleviate response without evident biotoxicity an vivo rat periodontitis model. These findings contribute therapeutic effect on periodontitis. Overall, for combating facilitating regeneration, demonstrating promising potential clinical treatment

Language: Английский

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Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

Small, Journal Year: 2024, Volume and Issue: 20(10)

Published: Jan. 4, 2024

Abstract Biofilm‐associated infections are one of the most challenging healthcare threats for humans, accounting 80% bacterial infections, leading to persistent and chronic infections. The conventional antibiotics still face their dilemma poor therapeutic effects due high tolerance resistance led by biofilm barriers. Nanotechnology‐based antimicrobials, nanoparticles (NPs), paid attention extensively considered as promising alternative. This review focuses on whole journey NPs against biofilm‐associated clarify it clearly, is divided into four processes in sequence 1) Targeting biofilms, 2) Penetrating barrier, 3) Attaching cells, 4) Translocating through cell envelope. Through outlining compositions properties biofilms bacteria recent advances present strategies each process comprehensively discussed combat well combined these with drug resistance, aiming guide rational design facilitate wide application

Language: Английский

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A multifunctional nanoplatform with “disruption and killing” function to improve the efficiency of conventional antibiotics for biofilm eradication

Journal of Material Science and Technology, Journal Year: 2024, Volume and Issue: 205, P. 98 - 108

Published: April 22, 2024

Language: Английский

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New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, gaining attention. Current novel biomaterials address key clinical issues like infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, tissue regeneration properties. However, strategies that integrate advantages these to achieve synergistic therapeutic effects by clearing biofilms, inhibiting inflammation activation, restoring periodontal soft hard functions remain very limited. Recent studies highlight link between periodontitis systemic diseases, underscoring complexity disease. There an urgent need find comprehensive treatment plans requirements. Whether integrating new enhance existing treatments or developing approaches replace traditional therapies, efforts will drive advancements in treatment. Therefore, this review compares with treatments. It highlights design concepts mechanisms functional materials, their properties, discusses importance strategies. This aims provide guidance for emerging research promote development precise efficient

Language: Английский

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Advanced biomaterials for targeting mature biofilms in periodontitis therapy

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492

Published: Feb. 27, 2025

Language: Английский

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Metal-organic framework-based advanced therapeutic tools for antimicrobial applications

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 175, P. 27 - 54

Published: Dec. 17, 2023

The escalating concern over conventional antibiotic resistance has emphasized the urgency in developing innovative antimicrobial agents. In recent times, metal−organic frameworks (MOFs) have garnered significant attention within realm of research due to their multifaceted attributes, including sustained release intrinsic or exogenous components, chemodynamically catalyzed generation reactive oxygen species (ROS), and formation photogenerated ROS. This comprehensive review provides a thorough overview synthetic approaches employed production MOF-based materials, elucidating underlying mechanisms depth. focal point lies advancements across various modalities, encompassing component system, extraneous auto-catalytical energy conversion system. Additionally, progress materials addressing wound infections, osteomyelitis, periodontitis is meticulously elucidated, culminating summary challenges potential opportunities inherent applications for materials. Growing concerns about need alternative solutions. Metal-organic gained diverse attributes like components release, catalytic covers MOF synthesis mechanisms. It explores auto-catalysis, systems. paper also discusses materials' periodontitis, along with existing opportunities. Given lack related reviews, our findings hold promise future antibacterial research, making it relevant your journal's readership.

Language: Английский

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Recent Progress in antibacterial hydrogel coatings for targeting biofilm to prevent orthopedic implant-associated infections

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 22, 2023

The application of orthopedic implants for bone tissue reconstruction and functional restoration is crucial patients with severe fractures defects. However, the abiotic nature allows bacterial adhesion colonization, leading to formation biofilms on implant surface. This can result in failure complications such as osteomyelitis septic arthritis. emergence antibiotic-resistant bacteria limited efficacy drugs against have increased risk implant-associated infections (OIAI), necessitating development alternative therapeutics. In this regard, antibacterial hydrogels based repelling, contact killing, drug delivery, or external assistance strategies been extensively investigated coating through surface modification, offering a promising approach target biofilm prevent OIAI. review provides an overview recent advancements hydrogel coatings preventing OIAI by targeting formation. topics covered include: (1) mechanisms underlying occurrence role exacerbating development; (2) current impart anti-biofilm properties involved treating article aims summarize progress prevention, providing valuable insights facilitating prognostic markers design effective implants.

Language: Английский

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Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)

Published: Jan. 30, 2024

Abstract Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive pulmonary disease, and celiac disrupt the delicate balance between bone resorption formation, leading to inflammatory loss. Conventional approaches tackle this issue encompass pharmaceutical interventions surgical procedures. Nevertheless, exhibit limited efficacy, while treatments impose trauma significant financial burden upon patients. Biomaterials show outstanding spatiotemporal controllability, possess a remarkable specific surface area, demonstrate exceptional reactivity. In present era, advancement of emerging biomaterials has bestowed more efficacious solutions for combatting detrimental consequences review, advances ameliorating loss are listed. Additionally, advantages disadvantages various biomaterials‐mediated strategies summarized. Finally, challenges perspectives analyzed. This review aims provide new possibilities developing advanced toward

Language: Английский

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Next‐generation antibacterial nanopolymers for treating oral chronic inflammatory diseases of bacterial origin

International Endodontic Journal, Journal Year: 2024, Volume and Issue: 57(7), P. 787 - 803

Published: Feb. 10, 2024

Abstract Background ‘Periodontitis’ refers to periodontal destruction of connective tissue attachment and bone, in response microorganisms forming subgingival biofilms on the root surface, while ‘apical periodontitis’ periapical inflammatory processes occurring within canal system. The treatment both diseases is based elimination bacterial challenge, though its predictability depends ability disrupting these biofilms, what may need adjunctive antibacterial strategies, such as next‐generation strategies (NGAS). From all newly developed NGAS, use polymeric nanotechnology pose a potential effective approach. Although some have only been tested vitro preclinical vivo models, their holds great potential, therefore, it relevant understand mechanism action evaluate scientific evidence efficacy. Objectives To explore NGAS used for periodontitis apical periodontitis. Method A systemic search publications antimicrobial using nanopolymers treat was conducted National Library Medicine (MEDLINE by PubMed), Cochrane Oral Health Group Trials Register, EMBASE Web Science. Results Different nanoparticles, nanofibres nanostructured hydrogels combined with substances identified literature, being most commonly polycaprolactone, poly(lactic‐ co ‐glycolic acid) chitosan. As antimicrobials, frequently antibiotics, other substances, metallic ions, peptides naturally derived products, also added nanopolymers. Conclusion Polymeric nanomaterials containing compounds be considered NGAS. Its relative efficacy, however, not well understood since existing from or studies.

Language: Английский

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Overview of Injectable Hydrogels for the Treatment of Myocardial Infarction

Cardiovascular Innovations and Applications, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Myocardial infarction (MI) triggers adverse remodeling mechanisms, thus leading to heart failure. Since the application of biomaterial-based scaffolds emerged as a viable approach for providing mechanical support and promoting cell growth, injectable hydrogels have garnered substantial attention in MI treatment because their minimally invasive administration through injection diminished risk infection. To fully understand interplay between infarcted myocardium repair, this review provides an overview recent advances hydrogel-mediated therapy, including: I) material designs repairing myocardium, considering pathophysiological mechanism design principles biomaterials treatment; II) development functional treatment, including conductive, self-healing, drug-loaded, stimulus-responsive hydrogels; III) research progress using restore cardiac function by neovascularization, enhancing cardiomyocyte proliferation, decreasing myocardial fibrosis, inhibiting excessive inflammation. Overall, presents current state hydrogel offering valuable information facilitate interdisciplinary knowledge transfer enable prognostic markers suitable materials.

Language: Английский

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