Titania–Graphene Oxide Nanocomposite-Based Philadelphia-Positive Leukemia Therapy DOI
Maria Batool, Rida‐e‐Maria Qazi, Muhammad Ahmad Mudassir

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 4352 - 4365

Published: June 20, 2024

Philadelphia-positive (Ph+) leukemia is a type of blood cancer also known as acute lymphoblastic (ALL), affecting 20–30% adults diagnosed worldwide and having an engraved prognosis compared to other types leukemia. The current treatment regimens mainly rely on tyrosine kinase inhibitors (TKIs) bone marrow transplants. To date, several generations TKIs have been developed due associated resistance frequent relapse, with cardiovascular system anomalies being the most devastating complication. Nanotechnology has potential address these limitations by targeted drug delivery controlled release TKIs. This study focused titanium dioxide (TiO2) graphene oxide (GO) nanocomposite employment load nilotinib ponatinib for therapy Ph+ cell line (K562) Ba/F3 cells engineered express BCR-ABL oncogene. Meanwhile, after treatment, oncogene expressing fibroblast (Rat-1 P185) were evaluated their colony formation ability under 3D conditions. validate formation, TiO2–GO nanocomposites characterized scanning electron microscope, DLS, XRD, FTIR, zeta potential, EDX, element mapping. TKI-loaded was not inferior free drugs evaluating effects viability assay (XTT), apoptosis induction, inhibition. signaling pathways mammalian target rapamycin (mTOR), signal transducers activators transcription 5 (STAT5), extracellular signal-regulated (Erk1/2) investigated Western blot. These significantly downregulated in TiO2–GO-treated groups. Based findings above, we can conclude that exhibited excellent be used future, subject further investigations.

Language: Английский

Navigating micro- and nano-motors/swimmers with machine learning: Challenges and future directions DOI Creative Commons
Jueyi Xue, Hamid Alinejad‐Rokny, Kang Liang

et al.

ChemPhysMater, Journal Year: 2024, Volume and Issue: 3(3), P. 273 - 283

Published: June 20, 2024

Micro-/nano-motors (MNMs) or swimmers are minuscule machines that can convert various forms of energy, such as chemical, electrical, magnetic into motion. These devices have attracted significant attention owing to their potential application in a wide range fields drug delivery, sensing, and microfabrication. However, diverse shapes, sizes, structural/chemical compositions, the development MNMs faces several challenges, understanding structure-function relationships, which is crucial for achieving precise control over motion within complex environments. In recent years, machine learning techniques shown promise addressing these challenges improving performance MNMs. Machine analyze large amounts data, learn from patterns, make predictions, thereby enabling navigate environments, avoid obstacles, perform tasks with higher efficiency reliability. This review introduces current state-of-the-art MNM research, particular focus on employing understand manipulate navigation locomotion Finally, we discuss opportunities this field suggest future research directions.

Language: Английский

Citations

7
Marangoni Effect Enabling Autonomously Miniatured Swimmers: Mechanisms, Design Strategy, and Applications DOI Open Access

Haidong Yu,

Yiming Wang, Zhiqiang Hou

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Miniature swimmers hold considerable potential for precision tasks in the confined environments, yet challenges persist with a simple, sustained, and controllable actuation their large‐scale applications real‐world scenarios. Marangoni‐propelled miniature (MPMSs), leveraging surface‐tension‐gradient‐driven interfacial flows, emerg as promising solution due to simple implementation scalable operation. The Marangoni effect, characterized by flow caused surface tension gradients, offers propulsion mechanism object movement at liquid surfaces. Leveraging this MPMSs have attracted great interest all over world. In regard, review provides an overview of latest advancement design application MPMSs, highlighting synergy various responsive materials structural engineering enable on‐demand gradients sustained MPMSs. First, it systematically introduces different mechanisms generation gradient actuate these swimmers. Subsequently, elaborately discusses preparation specialized designs employed while elucidating correlation between swimmer strategies. Furthermore, practical across scenarios are presented briefly. Finally, remaining along possible solutions presented.

Language: Английский

Citations

1
Low-Energy Photoresponsive Magnetic-Assisted Cleaning Microrobots for Removal of Microplastics in Water Environments DOI
Zhichao Wang, Lei Xu,

Xihang Cai

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(45), P. 61899 - 61909

Published: Nov. 4, 2024

In the global ecosystem, microplastic pollution pervades extensively, exerting profound and detrimental effects on marine life human well-being. However, conventional removal methods are usually limited to chemical flocculation physical filtration but insufficient remove extremely small microplastics. Therefore, developing a comprehensive strategy address threat posed by microplastics is imperative. Here, we report low-energy photoresponsive magnetic-assisted cleaning microrobot (LMCM) composed of photocatalytic material (Ag@Bi2WO6) magnetic nanoparticles (Fe3O4), which can be used for active from water environments. Due diffusion electrophoresis effect, microrobots (LCMs) formed spontaneous assembly Ag@Bi2WO6, continuously adsorb in environment. Particularly, effective attraction distance LCMs exceeds 100 μm. After assembling Fe3O4 nanoparticles, LMCMs clean groups environments under control field. Utilizing precision manipulation group control, demonstrate remarkable 98% efficiency 93 s recovered directional This eco-friendly energy-efficient expected provide viable tackle or promote industrial removal.

Language: Английский

Citations

5
Self‐Degradable Photoactive Micromotors for Inactivation of Resistant Bacteria DOI Creative Commons
Xiaojiao Yuan, Salvio Suárez‐García, Marco De Corato

et al.

Advanced Optical Materials, Journal Year: 2024, Volume and Issue: 12(16)

Published: March 14, 2024

Abstract Pathogenic bacteria pose a significant threat to human health, and their removal from food water supplies is crucial in preventing the spread of waterborne foodborne diseases. Recently, silver‐based photocatalytic micromotors have emerged as promising candidates for inactivating pathogenic microbes due high antibacterial activity. In this study, synthesis photoactive Ag 3 PO 4 with well‐defined tetrapod‐like structure (TAMs) presented using simple precipitation method. These TAMs autonomously move release ions/nanoparticles (NPs) through photodegradation process when exposed light, which enhances antimicrobial activity against Gram‐negative ( Escherichia coli ) Gram‐positive Staphylococcus aureus bacterial strains. Interestingly, different motion modes are observed under manipulated light wavelengths fuels. Furthermore, self‐degradation accelerated presence negatively charged bacteria, results higher rates both E. Coli S. . The findings introduce new concept self‐degradable based on components, hold great potential use applications. This work offers implications materials chemistry, especially designing developing next generation light‐driven agents.

Language: Английский

Citations

4
Strategies for intravesical drug delivery: From bladder physiological barriers and potential transport mechanisms DOI Creative Commons

Z.W. Li,

Kai-chao Wen,

Jiheng Liu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4738 - 4755

Published: July 6, 2024

Intravesical drug delivery (IDD), as a noninvasive, local pathway of administration, has great clinical significance for bladder diseases, especially cancer. Despite the many advantages IDD such enhanced focal exposure and avoidance systemic adverse reactions, effectiveness is greatly challenged by physiological barriers bladder. In this review, routes encountered in are first discussed, attention paid to potential internal/mucosal retention absorption-transport mechanisms drugs. On basis, avoidance, overcoming utilization "three barriers" further emphasized, current design fabrication strategies intravesical systems (IDDSs) described mainly from perspectives constructing reservoirs, enhancing permeability targeting, with hope providing systematic understanding inspirations research novel IDDSs their treatment diseases.

Language: Английский

Citations

4
Micro- and Nanomotors: Engineered Tools for Targeted and Efficient Biomedicine DOI Creative Commons
Noelia Ruiz‐González, David Esporrín‐Ubieto, Il‐Doo Kim

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Over the past two decades, nanotechnology has made significant progress toward development and applications of micromotors (MMs) nanomotors (NMs). Characterized by their capability to self-propel swim in fluids, they have emerged as promising tools various fields, particularly biomedicine. This Review presents an overview current state MMs NMs, motion viscous media complex environments, interaction with biological barriers, potential therapeutical applications. We identify choice appropriate administration routes reach target location a key aspect success NMs biomedical Looking ahead, we envision playing role treating diverse medical disorders, recent proof-of-concept vivo studies demonstrate distinct capabilities versatility. However, addressing regulatory, scalability, biocompatibility, safety concerns remains imperative for successful translation into clinical trials industrial-scale production. work provides guideline researchers, guiding them through landscape, challenges, prospects using biomedicine, thereby encouraging responsible positioning future nanomedicine. Furthermore, outline critical areas further research, including on safety, methods overcome physical obstacles.

Language: Английский

Citations

0
Dual-source powered sea urchin-like nanomotors for intravesical photothermal therapy of bladder cancer DOI Creative Commons
Yixuan Mou, Zhenghong Liu, Wentao Xu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 17, 2025

Bladder cancer (BCa) ranks as the 9th most prevalent malignancy worldwide, featured by its high risk of recurrence. Intravesical therapy constitutes important modality to tackle BCa, but efficiency is often compromised due dense physiological barriers in instability catalytic environment, and rapid clearance facilitated periodic urination. Here, we present a dual-source powered sea urchin-like nanomotor, which feature gold nanocore decorated with ultrasmall platinum nanoparticles ureases, enable propulsion through conversion abundant urea hydrogen peroxide bladder cavity BCa microenvironment, respectively. Our Au-Pt@ur NPs translocated across mucus barrier rapidly, deeply penetrated tumor hence chemo-resected tumors all cases. These results hold substantial promise for development biocompatible nanomotors improved intravesical therapy.

Language: Английский

Citations

0
Tubular Micromotors Functionalized with Doxorubicin-Loaded Liposomes for Drug Delivery and Light-Triggered Release DOI

S. BATORI,

Teruyuki Komatsu

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Language: Английский

Citations

0
Titania–Graphene Oxide Nanocomposite-Based Philadelphia-Positive Leukemia Therapy DOI
Maria Batool, Rida‐e‐Maria Qazi, Muhammad Ahmad Mudassir

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 4352 - 4365

Published: June 20, 2024

Philadelphia-positive (Ph+) leukemia is a type of blood cancer also known as acute lymphoblastic (ALL), affecting 20–30% adults diagnosed worldwide and having an engraved prognosis compared to other types leukemia. The current treatment regimens mainly rely on tyrosine kinase inhibitors (TKIs) bone marrow transplants. To date, several generations TKIs have been developed due associated resistance frequent relapse, with cardiovascular system anomalies being the most devastating complication. Nanotechnology has potential address these limitations by targeted drug delivery controlled release TKIs. This study focused titanium dioxide (TiO2) graphene oxide (GO) nanocomposite employment load nilotinib ponatinib for therapy Ph+ cell line (K562) Ba/F3 cells engineered express BCR-ABL oncogene. Meanwhile, after treatment, oncogene expressing fibroblast (Rat-1 P185) were evaluated their colony formation ability under 3D conditions. validate formation, TiO2–GO nanocomposites characterized scanning electron microscope, DLS, XRD, FTIR, zeta potential, EDX, element mapping. TKI-loaded was not inferior free drugs evaluating effects viability assay (XTT), apoptosis induction, inhibition. signaling pathways mammalian target rapamycin (mTOR), signal transducers activators transcription 5 (STAT5), extracellular signal-regulated (Erk1/2) investigated Western blot. These significantly downregulated in TiO2–GO-treated groups. Based findings above, we can conclude that exhibited excellent be used future, subject further investigations.

Language: Английский

Citations

2