A Review of the Impacts of Implant Stiffness on Fracture Healing

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 2259 - 2259

Published: March 7, 2024

The bone healing process is influenced by various physiological factors. Fracture fixation traditionally relied on rigid metallic implants. However, excessively constructs can lead to complications, necessitating revision surgery. This review focuses approaches improve introducing adequate interfragmentary movement (IFM) at the fracture site. IFM promotes secondary and callus formation. Studies suggest that may impair inhibiting formation causing stress shielding. Titanium alloy locking plates have been shown be biomechanically superior stainless steel. Flexible techniques regulate implant stiffness are crucial for managing fractures with bridge plating. Materials a lower Young’s modulus balance biomechanical properties. A novel TiNbSn low has developed address shielding issues. It effective in promoting osteosynthesis, healing, mechanical properties compared materials higher moduli. enhanced of associated suggests its promise use treatment plates. Understanding biomechanics optimizing stiffness, exploring innovative like alloys, advancing accelerate enhance healing.

Language: Английский

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Surface modification of the laser powder bed-fused Ti-Zr-Nb scaffolds by dynamic chemical etching and Ag nanoparticles decoration

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 161, P. 213882 - 213882

Published: April 28, 2024

Language: Английский

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Small intestine submucosa decorated 3D printed scaffold accelerated diabetic bone regeneration by ameliorating the microenvironment

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(37), P. 9375 - 9389

Published: Jan. 1, 2024

The 3D printed scaffolds constructed from polymers have shown significant potential in the field of bone defect regeneration. However, efficacy these can be markedly reduced certain pathological conditions like diabetes, where an altered inflammatory microenvironment and diminished small blood vessels complicate integration with host tissue. In this study, bioactivity a 3D-printed poly(lactide-

Language: Английский

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Current advances of 3D printing Ti-based multi-metals for bone regeneration

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 26, 2024

Language: Английский

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Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10386 - 10386

Published: Sept. 26, 2024

Mechanosensing and mechanotransduction pathways between the Extracellular Matrix (ECM) cells form essential crosstalk that regulates cell homeostasis, tissue development, morphology, maintenance, function. Understanding these mechanisms involves creating an appropriate support elicits signals to guide cellular functions. In this context, polymers can serve as ideal molecules for producing biomaterials designed mimic characteristics of ECM, thereby triggering responsive closely resemble those induced by a natural physiological system. The generated specific stimuli depend on different or synthetic origins polymers, chemical composition, assembly structure, physical surface properties biomaterials. This review discusses most widely used their customization develop with tailored properties. It examines how biomaterials-based be harnessed replicate functions biological cells, making them suitable biomedical biotechnological applications.

Language: Английский

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Synthetic nanointerfacial bioengineering of Ti implants: On-demand regulation of implant-bone interaction for enhancing osseointegration

Materials Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Nanointerfacial bioengineering of titanium-based implants with synthetic technologies could improve their osseointegration, showing promise to enhance interfacial osteogenesis, preventing peri-implant infection and overcome osteodegenerative stress.

Language: Английский

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Customization and prospects of friction stir processing for improving the biomedical properties of metallic implants for orthopedic applications

Journal of Materials Research and Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Enhanced osseointegration and antimicrobial properties of 3D-Printed porous titanium alloys with copper-strontium doped calcium silicate coatings

Journal of Biomaterials Applications, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

The 3D printing of porous titanium scaffolds reduces the elastic modulus alloys and promotes osteogenic integration. However, due to biological inertness alloy materials, implant-bone tissue interface is weakly bonded. A calcium silicate (CS) coating doped with polymetallic ions can impart various properties materials. In this study, CuO SrO binary-doped CS coatings were prepared on surface 3D-printed using atmospheric plasma spraying characterized by SEM, EDS, XRD. Both successfully incorporated into coating. in vivo osseointegration evaluation composite coating-modified was conducted a rabbit bone defect model, showing that 2% CuO-10% SrO-CS-modified improved. vitro antimicrobial evaluated through bacterial platform coating, co-culture liquid absorbance detection, crystal violet staining experiments, demonstrating exhibited good properties. conclusion, scaffold possesses both osteointegration-promoting properties, indicating broad potential for clinical applications.

Language: Английский

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Modified multilayered porous titanium scaffolds with silicon-doped coating surface-loaded BMP-2 prepared by microarc oxidation for bone defect repair

Surface and Coatings Technology, Journal Year: 2024, Volume and Issue: 495, P. 131570 - 131570

Published: Nov. 16, 2024

Language: Английский

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