Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(6), P. 1367 - 1367
Published: June 3, 2025
Objective:
Radiotherapy
is
a
primary
method
for
cancer
treatment,
wherein
radiation
doses
are
divided
into
multiple
sessions
or
fractions
to
effectively
target
tumors
and
minimize
damage
surrounding
tissues.
Methods:
In
this
study,
we
leverage
reinforcement
learning
(RL)
enhance
treatment
planning
with
the
aim
of
improving
adaptability
robustness
RL
agents
given
inherent
inaccuracies
in
tumor
growth
models.
A
2D
simulation
model
employed,
where
tabular
techniques
used
determine
optimal
strategies.
We
emphasize
significance
tissue
predictions
incorporate
Lyman
NTCP
assess
outcomes,
analyzing
complications
across
three
simulated
body
sites:
rectum,
head
neck
lung.
Results:
For
all
sites,
approach
significantly
reduces
healthy
by
10.7%,
49.1%
37.5%,
respectively,
rectal,
lung
cancers
compared
baseline
treatment.
Conclusions:
The
RL-based
radiotherapy
not
only
achieves
eradication
but
also
traditional
methods.
This
study
demonstrates
potential
optimize
radiotherapy,
offering
promising
path
towards
more
personalized
effective
treatments.
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Nanotechnology
enables
targeted
theranostics
by
enhancing
imaging
and
therapy.
This
review
explores
advances
in
pH-induced
charge-switchable
nanomaterials,
their
role
drug
delivery
contrast,
future
directions
the
field.
Dalton Transactions,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Recent
advances
in
polyoxometalate
(POM)-based
materials
with
biomedical
applications
indicate
significant
potential
the
therapeutic
field.
The
scientific
community
aims
to
advance
these
enhance
bioorthogonal
chemistry
of
POMs.
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(4), P. 341 - 341
Published: March 26, 2025
Cancer
treatment
has
historically
depended
on
conventional
methods
like
chemotherapy,
radiation,
and
surgery;
however,
these
strategies
frequently
present
considerable
limitations,
including
toxicity,
resistance,
negative
impacts
healthy
tissues.
In
addressing
challenges,
drug-free
cancer
therapies
have
developed
as
viable
alternatives,
utilizing
advanced
physical
biological
to
specifically
target
tumor
cells
while
reducing
damage
normal
This
review
examines
several
strategies,
such
high-intensity
focused
energy
beams,
nanosecond
pulsed
electric
fields,
photothermal
therapy
well
the
use
of
inorganic
nanoparticles
promote
selective
apoptosis.
We
also
investigate
significance
targeting
microenvironment,
precision
medicine,
immunotherapy
in
progression
personalized
therapies.
Although
approaches
demonstrate
significant
promise,
challenges
scalability,
safety,
regulatory
obstacles
must
be
resolved
for
clinical
application.
paper
presents
an
overview
current
research
therapies,
emphasizing
recent
advancements,
underlying
scientific
principles,
steps
required
implementation.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(14), P. 10484 - 10500
Published: Jan. 1, 2025
In
this
study,
a
series
of
3-benzyloxyflavone
derivatives
(1–10)
was
designed
and,
for
the
first
time,
evaluated
both
in
vitro
and
vivo
inhibitory
activity
against
β-glucosidase
enzyme.
