Nanoformula Design for Inducing Non‐Apoptotic Cell Death Regulation: A Powerful Booster for Cancer Immunotherapy DOI
Yi Hu, Qing Yu, Xia Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(2)

Published: Dec. 4, 2024

Abstract Cancer treatment has witnessed revolutionary advancements marked by the emergence of immunotherapy, specifically immune checkpoint blockade (ICB). However, inherent low immunogenicity tumor cells and intricate immunosuppressive network within microenvironment (TME) pose significant challenges to further development immunotherapy. Nanotechnology ushered in unprecedented opportunities vast prospects for Nevertheless, traditional nano‐formulations often rely on inducing apoptosis kill cancer cells, which encounters issue silencing, hindering effective activation. The non‐apoptotic modes regulated cell death (RCD), including pyroptosis, ferroptosis, autophagy, necroptosis, cuproptosis, have gradually garnered attention. These pathways can induce immunogenic (ICD), enhancing This review comprehensively explores advanced nano‐formulation design strategies their applications immunotherapy promoting RCD recent years. It also discusses potential advantages these tumor‐specific RCD. By deeply understanding significance synergistic this article provides valuable insights developing more nano‐delivery systems that robustly highly modes, offering novel research avenues address clinical encountered represented ICB.

Language: Английский

Biometallic ions and derivatives: a new direction for cancer immunotherapy DOI Creative Commons
Lin Zhao,

Yajun Gui,

Jing Cai

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 15, 2025

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.

Language: Английский

Citations

2
Single-atom–doped piezocatalyst induces copper-free cuproptosis in tumor therapy DOI Creative Commons
M. Zhang, Xinran Song, Yu Qin

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(7)

Published: Feb. 14, 2025

Cuproptosis, a distinct cell death pathway, has been integrated into nanomedicine for disease theranostics. However, current nanosystems inducing cuproptosis rely on exogenous toxic copper ions, limiting the scope of biomaterials. Developing nanoplatforms that induce without holds substantial promise. Here, we engineered two-dimensional iron (Fe) single-atom–doped molybdenum disulfide (MoS 2 ) piezocatalyst (Fe-MoS tumor therapy. Incorporating single Fe atoms enhances MoS piezoelectric polarization via charge redistribution and modulates Mo oxidation states, enabling multifaceted enzymatic activities, including peroxidase-, glutathione oxidase–, oxidase-, catalase-like activities. Upon ultrasound stimulation, Fe-MoS nanocatalyst generates reactive oxygen species depletes synergistic piezocatalytic enzyocatalytic effects, disrupting ion homeostasis cuproptosis, concurrently triggering ferroptosis ferritinophagy, which collectively suppression. This study represents first paradigm to introduce copper-free initiating substantially advancing applications in

Language: Английский

Citations

1
Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools DOI Creative Commons

Renwei Li,

Jing Huang, Yuhao Wei

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 13615 - 13651

Published: Dec. 1, 2024

Macrophage is an important component in the tumor immune microenvironment, which exerts significant influence on development and metastasis. Due to their dual nature of promoting suppressing inflammation, macrophages can serve as both targets for immunotherapy tools treating malignancies. However, abundant infiltration tumor-associated dominated by immunosuppressive phenotype maintains a pro-tumor engineering using nanotechnology manipulate microenvironment represent feasible approach cancer immunotherapy. Additionally, considering phagocytic specifically tumor-targeting capabilities M1 macrophages, manipulated through cellular nanotechnology, well macrophage-derived exosomes macrophage membranes, also become effective treatment. In conclusion, nanotherapeutics targeting remains immense potential macrophage-mediated treatment methods will further enhance our understanding, diagnosis, various malignants.

Language: Английский

Citations

2
Nanoformula Design for Inducing Non‐Apoptotic Cell Death Regulation: A Powerful Booster for Cancer Immunotherapy DOI
Yi Hu, Qing Yu, Xia Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(2)

Published: Dec. 4, 2024

Abstract Cancer treatment has witnessed revolutionary advancements marked by the emergence of immunotherapy, specifically immune checkpoint blockade (ICB). However, inherent low immunogenicity tumor cells and intricate immunosuppressive network within microenvironment (TME) pose significant challenges to further development immunotherapy. Nanotechnology ushered in unprecedented opportunities vast prospects for Nevertheless, traditional nano‐formulations often rely on inducing apoptosis kill cancer cells, which encounters issue silencing, hindering effective activation. The non‐apoptotic modes regulated cell death (RCD), including pyroptosis, ferroptosis, autophagy, necroptosis, cuproptosis, have gradually garnered attention. These pathways can induce immunogenic (ICD), enhancing This review comprehensively explores advanced nano‐formulation design strategies their applications immunotherapy promoting RCD recent years. It also discusses potential advantages these tumor‐specific RCD. By deeply understanding significance synergistic this article provides valuable insights developing more nano‐delivery systems that robustly highly modes, offering novel research avenues address clinical encountered represented ICB.

Language: Английский

Citations

1