Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion DOI Creative Commons
Liguo Zhang, Li Zhao,

Yajing Fu

et al.

Small Structures, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Bone defect repair involves a series of dynamic and complex processes, including immunoregulation, angiogenesis, osteogenesis. Herein, phased bioactive ions‐oriented release strategy is proposed to construct the bilayer Cu&Sr‐hydroxyapatite (HAp)/polylactic acid (CSHP‐)guided bone regeneration membrane. By harnessing distinct modes ion delivery, Cu 2+ adsorbed on surface can be released quickly from CSHP membrane trigger cascade events antibacterial reaction, regulating macrophage polarization, enhancing angiogenesis. With gradual degradation HAp, Sr doped in lattice sustainably released, synergistically immunity, encouraging genesis robust skeletal tissue. The structure also ensures oriented ions area, circumventing any systemic complications that might arise indiscriminate dispersal. Furthermore, nanoengineered HAp layer deters pathogenic colonization due low adhesion force, which effectively prevent formation bacterial biofilms infection after implantation. Overall, multifunctional membrane, based release, adapts requirements repair, thereby augmenting efficiency, providing reference for design advanced materials.

Language: Английский

Formulating Single Phasic Silicorhenanite (α- and β-Na2Ca4(PO4)2SiO4) Bioactive Glass Materials Competing with Commercial Crystalline Hydroxyapatite Bone Mineral for Biomedical Applications DOI

Vijayakumari Sugumaran,

K. Annamalai,

Elakkiya Krishnamoorthy

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Hydroxyapatite (HAP) is a well-known medically renowned bioactive material known for its excellent biocompatibility and mechanical stability, but it lacks fast bioactivity. The restricted release of ions from hydroxyapatite encourages the search faster that could replicate other properties HAP. A new sol-gel-mediated potentially glass mimic structure HAP can surpass performance bioactively has been formulated in this study. Lefebvre et al. suggested silicorhenanite phase with formula Na2Ca4(PO4)2SiO4 isostructural to hydroxyapatite; however, data support hypothesis are scant. This study succeeds developing apatite-growth-inducing particles similar hydroxyapatite. Also, first time, existence evolution two forms (α- β-Na2Ca4(PO4)2SiO4) have unraveled, their explored. effect calcination temperature on formation biomaterial notified by looking into result heat treatment 900 °C resulted α-Na2Ca4(PO4)2SiO4 (Sili 900) 1000 yielded β-Na2Ca4(PO4)2SiO4 1000). conveys finding not α-Na2Ca4(PO4)2SiO4. Raman spectroscopic analysis proved structural similarity Sili c-HAP, relative spectra possessing phosphate bands irrelevance c-HAP. vitro MTT assay using NIH 3T3 fibroblasts vivo wound healing confirm enhanced bioactivity compatibility compared favored presence silica matrix semicrystallinity. pH rapid ionic leaching out reactivity fluid. burst enhances clotting ability be good ibuprofen drug carrier, which potential challenger

Language: Английский

Citations

1
Advanced 3D-printed Antibacterial Nano 58S Bioglass/AgNPs/CeO2-based Scaffolds for Bone Tissue Engineering DOI Creative Commons
Indrajeet Singh, Ing Kong,

Ashok Viswakarma

et al.

Ceramics International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Phased Ions‐Release Bilayer‐Guided Bone Regeneration Membrane with Nanostructure‐Mediated Antibacterial Adhesion DOI Creative Commons
Liguo Zhang, Li Zhao,

Yajing Fu

et al.

Small Structures, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Bone defect repair involves a series of dynamic and complex processes, including immunoregulation, angiogenesis, osteogenesis. Herein, phased bioactive ions‐oriented release strategy is proposed to construct the bilayer Cu&Sr‐hydroxyapatite (HAp)/polylactic acid (CSHP‐)guided bone regeneration membrane. By harnessing distinct modes ion delivery, Cu 2+ adsorbed on surface can be released quickly from CSHP membrane trigger cascade events antibacterial reaction, regulating macrophage polarization, enhancing angiogenesis. With gradual degradation HAp, Sr doped in lattice sustainably released, synergistically immunity, encouraging genesis robust skeletal tissue. The structure also ensures oriented ions area, circumventing any systemic complications that might arise indiscriminate dispersal. Furthermore, nanoengineered HAp layer deters pathogenic colonization due low adhesion force, which effectively prevent formation bacterial biofilms infection after implantation. Overall, multifunctional membrane, based release, adapts requirements repair, thereby augmenting efficiency, providing reference for design advanced materials.

Language: Английский

Citations

1