Amorphous/Crystalline Urchin‐Like TiO₂ SERS Platform for Selective Recognition and Efficient Identification of Glutathione

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Glutathione serves as a common biomarkers in tumor diagnosis and treatment. The levels of its intracellular concentration permit detailed investigation the microenvironment. However, low polarization weak Raman scattering cross‐section make direct indirect detection challenging. This study designs an amorphous‐crystalline urchin‐like TiO 2 (AC‐UL‐TiO ) for accurate identification GSH GSSG. By synergistically regulating crystalline core amorphous shell, bandgap structure is optimized, thereby enhancing charge transfer efficiency. AC‐UL‐TiO demonstrates excellent SERS performance detecting dye molecules with good selectivity mixed analytes. enhancement factor (EF) R6G 6.89 × 10 6 , limit (LOD) −10 M. A SERS‐colorimetric dual‐modality platform developed based on @DTNB system to accurately monitor concentrations from 0 1000 µM, providing robust dual‐confirmation result. Importantly, combined principal component analysis method, can directly distinguish GSSG molecules. Besides, LOD are −8 M, which 100 times higher than that detection. These findings indicate holds potential trace microenvironments.

Language: Английский

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Zinc phthalocyanine and sulfasalazine coloaded nanoaggregates with Prussian blue functionalization for sensitizing tumor photothermal/photodynamic therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 509 - 521

Published: Jan. 14, 2025

Language: Английский

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Injectable, Biodegradable and Photothermal Hydrogel with Quorum Sensing Inhibitory Effects for Subcutaneous Fungal Infection Treatment

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Owing to the high invasion depth and easy formation of biofilms, treatment subcutaneous fungal infection is intractable challenging. Herein, we report an injectable biodegradable hydrogel with bactericidal, quorum sensing inhibition antioxidant activities for in situ infection. The (BEPE) was constructed by irradiating mixed bovine serum albumin (BSA), ε-polylysine epigallocatechin gallate (EGCG)-loaded mesoporous polydopamine (PDA) under near-infrared (NIR) light. BEPE exerted microbicidal effects against Candida albicans (99.5%) Streptococcus mutans (99.6%) through synergistic photothermal microbiocidal activity slowly released ε-polylysine. Moreover, gently EGCG from relatively bioavailability, synergistically inhibited destroyed biofilms inhibiting between microbes, resulting antibiofilm efficiency 80.5% C. albicans. An vivo study revealed that accelerates tissue regeneration via targeted formation, elimination alleviation inflammation situ, thereby promoting wound healing. This strategy will facilitate design multifunctional agents treatment.

Language: Английский

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Pyrrolopyrrole Cyanine-Based Polymer with Superior Multifunctionality for Boosting Cancer Phototheranostics

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1431 - 1439

Published: March 19, 2025

Molecular agents with exceptional multifunctionality are highly sought for phototheranostic applications. Herein we present a high-performance polymer near-infrared II (NIR-II) fluorescence and photoacoustic (PA) imaging-guided mild photothermal therapy (mPTT) of tumors. We synthesize series semiconducting polymers based on pyrrolopyrrole cyanine, identifying that P(P-T) exhibits large mass extinction coefficient (139 L g–1 cm–1), excellent performance, bright NIR-II fluorescence, PA imaging signals, making it among the highest-performing in these properties. A tumor-targeting agent was developed by coencapsulating heat shock protein (HSP) inhibitor camouflaging M1 macrophage membranes. The integration enables comprehensive tumor site delineation, guiding subsequent therapeutic intervention. In 4T1 tumor-bearing mice, synergistic effect mPTT under low-power 808 nm laser irradiation, combined HSP inhibition, resulted significant suppression. This work offers valuable insights designing advanced agents.

Language: Английский

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Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 7, 2025

Cancer cells display a distinctive defense mechanism against any exogenous moieties that renders all treatments inefficient. Glutathione, thiol tripeptide plays paradoxical role in cancer as intracellular glutathione (GSH) are voracious scavengers of free radicals produced by chemotherapy, generation reactive oxygen species (ROS) and nitrogen (RNS). show Warburg effect, wherein the GSH levels exceptionally enhanced to overcome oxidative stress created ROS/RNS production or other generated side products redox reactions. Therefore, resetting is essential maintain homeostasis for cell survival their proliferation trigger escalation levels. Nanotherapeutics have facilitated targeted delivery GSH-depleting agents combination with radiotherapy, novel therapeutic interventions including chemodynamic therapy (CDT), photodynamic (PDT), ferroptosis induction, sonodynamic (SDT), immunotherapy being explored. This review aims compile strategic cells, importance nanotherapeutics depletion target numerous forms programmed death (PCD), apoptosis, ferroptosis, necroptosis, autophagy.

Language: Английский

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Hematoporphyrin-Modified Dendrimers Combined Immunoadjuvants for Enhanced Photoimmunotherapy of Colorectal Cancer

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Photoimmunotherapy has emerged as a promising strategy for cancer therapy due to its increased therapeutic effect, ability reverse drug resistance, and enhanced immune activation. But there is still lack of effective nanomaterial-based photothermal (PTT) or photodynamic (PDT) agents in photoimmunotherapy. In this study, photosensitizer hematoporphyrin-modified G5 PAMAM (G5-HP) nanomaterials are synthesized, which exhibit excellent conversion capability effects under 660 nm irradiation, effectively inducing tumor cell ablation immunogenic death (ICD). Besides, ICD induced by G5-HP can generate tumor-associated antigens, thereby enhancing dendritic (DC) maturation subsequent T addition, polymers bind Toll-like receptor (TLR) agonists CpG-ODN through electrostatic interaction, forming stable G5-HP/CpG nanoparticles. The incorporation an immunoadjuvant further amplified DC maturation, synergizing with phototherapy strengthen antitumor immunity. Notably, vivo studies confirmed that nanoparticles significantly suppressed colorectal growth laser while maintaining biocompatibility. Taken together, the synthesized perform PTT PDT efficacy, formed integrate DC-mediated immunotherapy. This study offers treatment, leveraging synergistic immunotherapy achieve superior outcomes.

Language: Английский

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Cationic Azobenzene Tag to Enhance Liposomal Prodrug Retention and Tumor-Targeting Prodrug Activation for Improved Antitumor Efficacy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

In this study, we reported a cationic azobenzene (Azo) tag to increase the retention of camptothecin (CPT) prodrugs in liposomes driven by π-π stacking interaction between Azo. Compared with CPT prodrug without Azo, liposome-encapsulating Azo-linked (AzoCPT-Lips) exhibited slower leakage plasma and longer blood circulation time mice. The AzoCPT-Lips had high encapsulation efficiency (95%), loading capacity (20%, weight), good storage stability. AzoCPT was efficiently taken up 4T1 tumor cells (100-fold higher than CPT) readily converted into active cytoplasm exert 10-fold cytotoxicity free CPT. More importantly, resulted 5-20 times distribution that solution or those other tissues, which further led more potent antitumor activity lower toxicities breast cancer xenograft. Such Azo represents an effective strategy for developing liposomal drugs improved efficacy.

Language: Английский

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Photovoltaic Molecule‐Based Phototheranostics With A‐D‐A Structure for Near‐Infrared Fluorescence Imaging‐Guided Synergetic Photodynamic and Photothermal Therapy of Tumors

Luminescence, Journal Year: 2024, Volume and Issue: 39(10)

Published: Oct. 1, 2024

ABSTRACT Phototheranostics with near‐infrared fluorescence and reactive oxygen species generation ability high photothermal conversion efficiency (PCE) plays a significant role in imaging‐guided synergetic photodynamic therapy of tumors. Here, star molecule organic photovoltaic materials, NCBDT‐4C an A‐D‐A conjugated structure, was assembled DSPE‐PEG‐NH 2 to prepare water dispersive nanoparticles (NPs). The prepared NCBDT‐4Cl NPs exhibited maximum NIR absorption peak at 764 nm 798 nm. These could generate superoxide anion, singlet ( 1 O ), heat under 808 laser irradiation. quantum yield PCE the were 37.5% 53.6%, respectively. combination cancer demonstrated vitro vivo. This work presents advanced application materials phototherapy.

Language: Английский

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