A Pair of Deep Red Phosphorescent Responsive Emissive Cyclometalated Iridium (III) Complexes as Carbonic Anhydrase Inhibitor and Effective Theranostic Photosensitizer DOI Open Access

Jiayan Yang,

Ting Wang, Pengchao Wang

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Herein, two deep red phosphorescent responsive emissive cyclometalated iridium (III) complexes with CAIX inhibition moiety was designed and synthesized; they can penetrate into living cells quickly mainly located in the lysosome. They showed a strong binding affinity towards vitro effectively reduced cellular expression of CAIX. Moreover, tethered CAIX‐inhibition benzene sulfonamide decrease inherent cytotoxicity Ir(III) complex normal improve killing selectivity cancer dark; Ir3 Ir4 exhibit approximately five to eight times higher than that cisplatin; satisfied photodynamic therapy effect under irradiation 425 nm, ultimately resulting apoptosis cell, which is accompanied weakening extracellular acidification, increased expression, significant loss mitochondrial membrane potential, elevated level reactive oxygen. our work may demonstrate combination metal photosensitizer provide promising strategy for constructing novel theranostic platform.

Language: Английский

Applications and Enhancement Strategies of ROS-based Non-invasive Therapies in Cancer Treatment DOI Creative Commons
Qiuyan Guo,

Yingnan Tang,

Shengmei Wang

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515

Published: Jan. 1, 2025

Language: Английский

Citations

2
Photodynamic Therapy Review: Past, Present, Future, Opportunities and Challenges DOI Creative Commons

Yaran Allamyradov,

Justice ben Yosef,

Berdimyrat Annamuradov

et al.

Photochem, Journal Year: 2024, Volume and Issue: 4(4), P. 434 - 461

Published: Oct. 1, 2024

Photodynamic therapy (PDT) is a medical treatment that utilizes photosensitizing agents, along with light, to produce reactive oxygen species can kill nearby cells. When the photosensitizer exposed specific wavelength of it becomes activated and generates destroy cancer cells, bacteria, other pathogenic micro-organisms. PDT commonly used in dermatology for treating actinic keratosis, basal cell carcinoma, skin conditions. It also being explored applications oncology, such as esophageal lung cancers, well ophthalmology age-related macular degeneration. In this study, we provide comprehensive review PDT, covering its fundamental principles mechanisms, critical components function. We examine key aspects including current clinical potential future developments. Additionally, discuss advantages disadvantages addressing various challenges associated implementation optimization. This aims offer thorough understanding highlighting transformative treatments while acknowledging areas requiring further research development.

Language: Английский

Citations

7
Near-Infrared Light Activatable Iridium(III) Complexes for Synergistic Photodynamic and Photochemotherapy DOI Creative Commons

Monika Negi,

V. Venkatesh

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

NIR activatable, self-degradable iridium( iii )–dithiocarbamate–cyanine complexes were synthesized. They act as type I and II PDT agent at ultra-low-power irradiation high laser power, they exhibited photoactivated chemotherapy (PACT).

Language: Английский

Citations

0
Synergistic Comprehensive Activation Methods for Dual‐Modality PDT and Hypoxia‐Triggered Chemotherapy Guided by NIR‐II Imaging beyond 1700 nm in Deep Tumors DOI
Hao Chen, Sheng-Nan Liu, Wang Wang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Although photodynamic therapy (PDT) holds great promise for applications in cancer treatment, it has limited effectiveness against deep hypoxic tumors. Moreover, the lack of visualization guidance precision theranostics poses additional challenges, hindering its broader clinical adoption. By combining NIR‐IIc (1800 nm) imaging with internally and externally activatable dual‐modality PDT hypoxia‐triggered chemotherapy, this study proposes a conceptual framework to overcome these limitations. This approach involves use photoswitchable lanthanide‐doped nanoparticles featuring Tm 3+ ‐activated upconversion/downshifting emissions coupled carboxyl‐terminated Ir(III) complex‐based Type I/II photosensitizer form nanophotosensitizer. The findings demonstrate that system enabled upon 808/980 nm excitation while selectively activating external under 980 irradiation, thereby ensuring accurate minimizing phototoxicity risk. complex conjugates luminol self‐illuminating photosensitizer, which can respond elevated H 2 O levels tumor microenvironment, effectively catalyzing chemiluminescence‐assisted PDT. aggravates hypoxia, turn activates hypoxia‐activatable prodrugs like tirapazamine, resulting synergistic antitumor effect. With imaging‐guided PDT, introduces groundbreaking unites significantly advancing precise effective treatment

Language: Английский

Citations

0
Investigation of Photophysicochemical Properties of Peripheral Tetra-Substituted Zn(II) and Mg(II) Phthalocyanine Compounds Containing Thiol Group DOI

Gunseli Guney,

Yunus Penlik,

Oğuzhan Avcıata

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142021 - 142021

Published: March 1, 2025

Language: Английский

Citations

0
Advanced strategies in the design of Ir(III) biscyclometalated complexes for PDT DOI
Juan Sanz-Villafruela, Arancha Carbayo, Marta Martı́nez-Alonso

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216572 - 216572

Published: March 14, 2025

Language: Английский

Citations

0
Hydrophilic vs. amphiphilic anionic Zn(II) phthalocyanines for photodynamic therapy DOI Creative Commons

Nouf S. Al‐Hamdan,

Ethar S. Makhseed,

Ali Husain

et al.

Kuwait Journal of Science, Journal Year: 2025, Volume and Issue: unknown, P. 100415 - 100415

Published: March 1, 2025

Language: Английский

Citations

0
PEGylated BODIPY Photosensitizer for Type I Dominant Photodynamic Therapy and Afterglow Imaging DOI
Hui Wen, Qihang Wu,

Xiujuan Xiang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(45), P. 61739 - 61750

Published: Oct. 30, 2024

Type I photodynamic therapy (PDT) exhibits outstanding therapeutic effects in hypoxic environments tumors, but the design of type photosensitizers (PSs), especially those with simple structures dramatic properties, remains a challenge. Herein, we report strategy for developing PSs one molecule afterglow luminescence. As proof concept, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) PS (BIP) bearing water-soluble poly(ethylene glycol) (mPEG550) chains is synthesized, and BIP can self-assemble into nanoparticles (BIPNs). Interestingly, BIPNs exhibit an O2•--triggered luminescence, which scarce, BODIPY derivatives. demonstrate dominant PDT at ultralow dose under both normoxic environments, significantly inhibit tumor growth irradiation. This work highlights high-performance luminescence excellent effects, underscoring significant potential versatile clinical theranostics.

Language: Английский

Citations

3
Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies DOI Creative Commons
Bishnu Das

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Transition metal complex-loaded nanosystems (TMCNs) represent a cutting-edge platform for stimuli (light, ultrasound)-responsive cancer therapies. These nanosystems, incorporating metals such as manganese(II), zinc(II), ruthenium(II), rhenium(I), iridium(III), and platinum(IV), significantly enhance the efficacy of light-activated therapies, including photodynamic therapy (PDT) photothermal (PTT), well ultrasound-activated treatments like sonodynamic (SDT). TMCNs based on iridium(III) improve PDT, while manganese(II) demonstrate exceptional sonosensitizing properties. In PTT, ruthenium(II) iridium(III)-based efficiently absorb light generate heat. Emerging synergistic approaches that combine SDT, chemotherapy, immunotherapy are demonstrated to be powerful strategies precision treatment. Zinc(II), platinum(IV)-based play critical role in optimizing these enhancing tumor targeting, reducing side effects. Furthermore, can amplify by inducing immunogenic cell death, thus strengthening immune response. advances address key challenges hypoxia therapeutic resistance, opening new possibilities innovative photosensitizer-based treatments. This review highlights latest progress design applications, demonstrating their potential revolutionize stimuli-responsive

Language: Английский

Citations

1
Breaking the deep-red light absorption barrier of iridium(III)-based photosensitizers. DOI
Gloria Vigueras, Gilles Gasser, José Ruiz

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Recent advancements in ligand design and fluorophore functionalization enable Ir( iii ) photosensitizers to achieve deep-red/near-infrared absorption, addressing challenges photodynamic therapy for deep-seated tumors.

Language: Английский

Citations

1