Synergic effects of core-shell nanospheres and magnetic field for sciatic nerve regeneration in decellularized artery conduits with Schwann cells DOI Creative Commons
Majid Sharifi, Majid Salehi,

Somayeh Ebrahimi‐Barough

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

Numerous conduits have been developed to improve peripheral nerve regeneration. However, challenges remain, including remote control of conduit function, and programmed cell behaviors like orientation. We synthesized Fe3O4-MnO2@Zirconium-based Metal-organic frameworks@Retinoic acid (FMZMR) core-shell assessed their impact on Schwann function behavior within made from decellularized human umbilical arteries (DHUCA) under magnetic field (MF). FMZMR core-shell, featuring a spherical porous structure catalytic properties, effectively scavenges radicals facilitates controlled drug release MF. The histology the DHUCA indicates effective decellularization with adequate tensile strength Young's modulus for sciatic In-vitro results demonstrate that is biocompatible promotes proliferation through remotely release. Furthermore, its synergy MF enhances orientation increases neurite length by ~ 1.93-fold. Functional histological evaluations indicate combined regeneration, decreases muscle atrophy, new neuron growth myelin formation, without negatively affecting vital tissues. This study suggests synergistic effect can alleviate some treatment challenges.

Language: Английский

Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics DOI Creative Commons
Dilip Kumar Chandra, Awanish Kumar, Chinmaya Mahapatra

et al.

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406

Published: Feb. 1, 2025

Language: Английский

Citations

6
Advances in metal-organic framework-based drug delivery systems DOI

M T Khulood,

U. S. Jijith,

Punnoth Poonkuzhi Naseef

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125380 - 125380

Published: Feb. 1, 2025

Language: Английский

Citations

1
Progress of metal-organic frameworks in improving the effect of sonodynamic therapy DOI Creative Commons
Qiang Cai, Jine Wang,

Ruhui Yan

et al.

Biomedical Technology, Journal Year: 2025, Volume and Issue: 9, P. 100070 - 100070

Published: Feb. 14, 2025

Language: Английский

Citations

0
Mesoporous silica micro/nanomotors: A new horizon in biomedical applications and precision medicine DOI Creative Commons

Farah M. El-Makaty,

Ma.Ellyza Andrea J. Ona,

Xiaomin Li

et al.

Applied Materials Today, Journal Year: 2025, Volume and Issue: 43, P. 102673 - 102673

Published: March 13, 2025

Citations

0
Crystallization-driven layer-by-layer amphiphilic block copolymer co-assembly with planar cargo molecules DOI

Huiying Zuo,

Kaibin Chen,

Hong Zhai

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 114019 - 114019

Published: May 1, 2025

Language: Английский

Citations

0
Metal-organic frameworks treating diabetic skin wounds by endogenous/exogenous responses DOI Creative Commons
Liang Chen, Lingling Wu, Mao Xie

et al.

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 7, P. 100177 - 100177

Published: Jan. 1, 2025

Language: Английский

Citations

0
Improved topical delivery of curcumin by hydrogels formed by composite carriers integrated with cyclodextrin metal-organic frameworks and cyclodextrin nanosponges DOI Creative Commons

Songting Li,

Long Meng,

Jiaqi Li

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100310 - 100310

Published: Dec. 1, 2024

Curcumin (CUR) is highly promising for topical therapeutic applications, but water-insolubility one of the major challenges plaguing its drugability, while conventional lipid nanocarriers are limited by low drug-carrying capacity, many additives, and complex processes. In current work, we constructed a composite carrier integrated with cyclodextrin metal-organic framework (γ-CD-MOF) nanosponge (β-CDNS), in which γ-CD-MOF had 13.9 % drug loading 267.1-fold increase solubility water CUR, β-CDNS showed bioadhesion further increasing solubility. The (γ-CD-MOF@β-CDNS) significantly improved vitro release transdermal permeation absorption properties excellent create an advantage local administration treating diseases high exudate, prevents affected area from deteriorating condition counter-absorption formulation. Thus, this contributes new option to address delivery insoluble drugs offers strategy clinical application CUR.

Language: Английский

Citations

3
Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach DOI
M. Akhtar, Hammad Majeed, Tehreema Iftikhar

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 31, 2024

Abstract Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at price of environment. Due to rise in illnesses, Industry 6.0 calls for a renewed dedication sustainability with latest technologies. Focused research creative solutions are needed achieve UN Sustainable Development Goals (SDGs), especially 3, 9, 13, 14, 15, 17. A promising sustainable technology enhancing healthcare while reducing environmental effect is Metal Organic Frameworks (MOFs). MOFs perfect drug administration because their high surface areas, adjustable pore sizes, remarkable drug-loading capacities. They created by combining advanced artificial intelligence, intelligent manufacturing, quantum computing. Researchers can create functional groups or ligands that bind selectively target cells tissues, minimizing off-target effects, thanks distinct benefits families like MIL, HKUST, UiO, ZIF etc. offer targeted delivery. Combining other nanomaterials results multipurpose systems handle challenging biomedical issues. Despite its promise, there still issues MOFs’ possible toxicity long-term stability physiological settings. To advance medicinal applications, these problems must be resolved. increase usefulness medicine critically analysing limitations putting up alternatives. The creation technologies (additive manufacturing etc.) delivery prime example how scientific stewardship may coexist provide advantageous both people

Language: Английский

Citations

2
Synergic effects of core-shell nanospheres and magnetic field for sciatic nerve regeneration in decellularized artery conduits with Schwann cells DOI Creative Commons
Majid Sharifi, Majid Salehi,

Somayeh Ebrahimi‐Barough

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

Numerous conduits have been developed to improve peripheral nerve regeneration. However, challenges remain, including remote control of conduit function, and programmed cell behaviors like orientation. We synthesized Fe3O4-MnO2@Zirconium-based Metal-organic frameworks@Retinoic acid (FMZMR) core-shell assessed their impact on Schwann function behavior within made from decellularized human umbilical arteries (DHUCA) under magnetic field (MF). FMZMR core-shell, featuring a spherical porous structure catalytic properties, effectively scavenges radicals facilitates controlled drug release MF. The histology the DHUCA indicates effective decellularization with adequate tensile strength Young's modulus for sciatic In-vitro results demonstrate that is biocompatible promotes proliferation through remotely release. Furthermore, its synergy MF enhances orientation increases neurite length by ~ 1.93-fold. Functional histological evaluations indicate combined regeneration, decreases muscle atrophy, new neuron growth myelin formation, without negatively affecting vital tissues. This study suggests synergistic effect can alleviate some treatment challenges.

Language: Английский

Citations

1