Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

Advanced Drug Delivery Reviews, Journal Year: 2019, Volume and Issue: 143, P. 68 - 96

Published: March 1, 2019

Language: Английский

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Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(9), P. 5397 - 5434

Published: Jan. 1, 2021

Nanoparticles (NPs) have attracted considerable attention in various fields, such as cosmetics, the food industry, material design, and nanomedicine. In particular, fast-moving field of nanomedicine takes advantage features NPs for detection treatment different types cancer, fibrosis, inflammation, arthritis well neurodegenerative gastrointestinal diseases. To this end, a detailed understanding NP uptake mechanisms by cells intracellular localization is essential safe efficient therapeutic applications. first part review, we describe several endocytic pathways involved internalization discuss impact physicochemical properties on process. addition, potential challenges using inhibitors, markers genetic approaches to study endocytosis are addressed along with principal (semi) quantification methods uptake. The second focuses synthetic bio-inspired substances, which can stimulate or decrease cellular NPs. This approach could be interesting where high accumulation drugs target desirable clearance immune avoided. review contributes an improved reveals used improve delivery.

Language: Английский

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Light‐Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo

Advanced Materials, Journal Year: 2016, Volume and Issue: 29(6)

Published: Dec. 6, 2016

Photocross-linkable Au nanoparticles are prepared through surface decoration of photolabile diazirine moieties. Both in vitro and vivo studies indicate that the light-triggered cross-linking can dramatically shift plasmon resonance to near-infrared regions, which consequence remarkably enhances their efficacy for photothermal therapy photoacoustic imaging tumors vivo.

Language: Английский

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Precise nanomedicine for intelligent therapy of cancer

Science China Chemistry, Journal Year: 2018, Volume and Issue: 61(12), P. 1503 - 1552

Published: Dec. 1, 2018

Language: Английский

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Advances in Chitosan-Based Nanoparticles for Drug Delivery

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(17), P. 9652 - 9652

Published: Sept. 6, 2021

Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, targeting specificity. Drug transport release from CS-based particulate systems depend the extent cross-linking, morphology, size, density system, well physicochemical drug. All these aspects to be considered when developing new potential delivery systems. This comprehensive review is summarizing discussing recent advances being developed examined for delivery. From this point view, enhancement CS by its modification presented. An discussed detail focusing (i) a brief summarization basic characteristics NPs, (ii) categorization preparation procedures used involving also improvements production schemes conventional novel (iii) evaluation CS-based-nanocomposites their with organic polymers inorganic material, (iv) very implementations nanocomposites

Language: Английский

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Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Advanced Science, Journal Year: 2020, Volume and Issue: 8(3)

Published: Dec. 20, 2020

Abstract Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving topics ROS‐regulating therapy such as antioxidant triggered by scavengers ROS‐induced toxic mediated ROS‐elevation agents. Benefiting from remarkable advances nanotechnology, a large number nanomaterials with ability are developed to seek new effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements been made ROS‐based nanomedicines treatments, some fundamental but key questions rational design principle held low regard. Here, can serve initial framework scientists technicians optimize nanomedicines, thereby minimizing gap biomedical application during stage. Herein, overview current progress ROS‐associated is summarized. And then, particularly addressing these known strategies therapy, several principles presented. Finally, future perspectives also discussed depth development

Language: Английский

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Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy

Biomaterials, Journal Year: 2017, Volume and Issue: 136, P. 98 - 114

Published: May 8, 2017

Language: Английский

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Small gold nanorods laden macrophages for enhanced tumor coverage in photothermal therapy

Biomaterials, Journal Year: 2015, Volume and Issue: 74, P. 144 - 154

Published: Oct. 1, 2015

Language: Английский

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Erythrocyte Membrane-Coated Upconversion Nanoparticles with Minimal Protein Adsorption for Enhanced Tumor Imaging

ACS Applied Materials & Interfaces, Journal Year: 2017, Volume and Issue: 9(3), P. 2159 - 2168

Published: Jan. 4, 2017

Upconversion nanoparticles (UCNPs) with superior optical and chemical features have been broadly employed for in vivo cancer imaging. Generally, UCNPs are surface modified ligands active targeting. However, biological fluids known to form a long-lived "protein corona", which covers the targeting on nanoparticle dramatically reduces capabilities. Here, first time, we demonstrated that by coating red blood cell (RBC) membranes, resulting membrane-capped (RBC-UCNPs) adsorbed virtually no proteins when exposed human plasma. We further observed various scenarios ability of folic acid (FA)-functionalized (FA-RBC-UCNPs) was rescued membrane coating. Next, FA-RBC-UCNPs were successfully utilized enhanced tumor Finally, parameters histology analysis suggested significant systematic toxicity induced injection biomimetic nanoparticles. Our method provides new angle design targeted biomedical applications.

Language: Английский

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Surface Charge Controls the Suborgan Biodistributions of Gold Nanoparticles

ACS Nano, Journal Year: 2016, Volume and Issue: 10(5), P. 5536 - 5542

Published: May 10, 2016

Surface chemistry plays a deciding role in nanoparticle biodistribution, yet very little is known about how surface influences the suborgan distributions of nanomaterials. Here, using quantitative imaging based on laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), we demonstrate that charge dictates nanoparticles kidney, liver, and spleen mice intravenously injected with functionalized gold nanoparticles. Images kidney show positively charged accumulate extensively glomeruli, initial stage filtering for nephron, suggesting these may be filtered by at different rate than neutral or negatively We find red pulp spleen. In contrast, uncharged white marginal zone to greater extent Moreover, are also more likely found associated Kupffer cells liver. Positively liver hepatocytes, whereas broader distribution Together observations suggest having 2 nm cores interact immune system nanoparticles, highlighting value determining nanomaterials delivery applications.

Language: Английский

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