Nano Today, Journal Year: 2021, Volume and Issue: 42, P. 101358 - 101358
Published: Dec. 28, 2021
Language: Английский
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: Feb. 22, 2022
Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.
Language: Английский
Citations
272
Advanced Science, Journal Year: 2020, Volume and Issue: 8(3)
Published: Dec. 20, 2020
Abstract Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving topics ROS‐regulating therapy such as antioxidant triggered by scavengers ROS‐induced toxic mediated ROS‐elevation agents. Benefiting from remarkable advances nanotechnology, a large number nanomaterials with ability are developed to seek new effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements been made ROS‐based nanomedicines treatments, some fundamental but key questions rational design principle held low regard. Here, can serve initial framework scientists technicians optimize nanomedicines, thereby minimizing gap biomedical application during stage. Herein, overview current progress ROS‐associated is summarized. And then, particularly addressing these known strategies therapy, several principles presented. Finally, future perspectives also discussed depth development
Language: Английский
Citations
271
Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 418, P. 129431 - 129431
Published: March 21, 2021
Language: Английский
Citations
257
ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 431 - 452
Published: Dec. 27, 2021
Designing translational antioxidative agents that could scavenge free radicals produced during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main objective for ischemic treatment. Herein, we explored simply synthesized a biomimic Mn3O4 nanoenzyme (HSA-Mn3O4) to constrain reperfusion-induced nervous system injury. This nanosystem exhibits reduced levels of inflammation prolonged circulation time potent ROS scavenging activities. As expected, HSA-Mn3O4 effectively inhibits oxygen glucose deprivation-mediated cell apoptosis endoplasmic reticulum stress demonstrates neuroprotective capacity against injury tissue. Furthermore, releases Mn ions promotes increase superoxide dismutase 2 activity. Therefore, tissue by restraining vivo. Taken together, this study not only sheds light on design nanomedicine but also reveals action mechanisms
Language: Английский
Citations
150
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 88, P. 101955 - 101955
Published: May 15, 2023
Language: Английский
Citations
139
Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 135039 - 135039
Published: Feb. 4, 2022
Language: Английский
Citations
133
Materials Today Bio, Journal Year: 2021, Volume and Issue: 11, P. 100124 - 100124
Published: June 1, 2021
Reactive oxygen species (ROS) mediate multiple physiological functions; however, the over-accumulation of ROS causes premature aging and/or death and is associated with various inflammatory conditions. Nevertheless, there are limited clinical treatment options that currently available. The good news owing to considerable advances in nanoscience, types nanomaterials unique ROS-scavenging abilities influence temporospatial dynamic behaviors biological systems have been developed. This has led emergence next-generation nanomaterial-controlled strategies aimed at ameliorating ROS-related Accordingly, herein we reviewed recent progress research on nanotherapy based scavenging. underlying mechanisms employed emphasized. Furthermore, important issues developing cross-disciplinary nanomedicine-based for ROS-based conditions discussed. Our review this increasing interdisciplinary field will benefit ongoing studies applications nanomedicine
Language: Английский
Citations
123
Advanced Materials, Journal Year: 2022, Volume and Issue: 34(19)
Published: March 11, 2022
Imaging-guided real-time monitoring of the treatment process inflammatory diseases is important for timely adjustment planning to lower unnecessary side effects and improve outcomes. However, it difficult reflect dynamic changes inflammation in vivo with enough tissue penetration depth. Here a novel nanotheranostic agent (denominated TMSN@PM) platelet membrane (PM)-coated, tempol-grafted, manganese-doped, mesoporous silica nanoparticles developed. The PM endows TMSN@PM ability target sites, which are verified by fluorescence imaging Cyanine5 carboxylic acid (Cy5)-labeled TMSN@PM. Under environment (mild acidity excess reactive oxygen species (ROS)), can scavenge ROS, thereby alleviating inflammation, degrade, release manganese ions enhanced magnetic resonance (MRI). relaxation (ΔR1 ) almost linearly correlated concentration H2 O2 , degree inflammation. This method offers non-invasive imaging-based strategy early prediction therapeutic outcomes therapy, may contribute precision medicine terms prognostic stratification future.
Language: Английский
Citations
98
ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(5), P. 6404 - 6416
Published: Jan. 25, 2022
In situ oxygen generation is the most common strategy to boost reactive species (ROS) for enhancing efficacy of phototherapy in cancer, including photodynamic therapy (PDT) and photothermal (PTT). However, hyperoxidation or hyperthermia often triggers stress-defense pathways promotes tumor cell survival, thus severely limiting therapeutic efficacy. To overcome hypoxia thermal resistance existing phototherapy, we constructed a self-synergistic nanoplatform tumors by incorporating brusatol, nuclear factor erythroid 2-related (Nrf2) inhibitor, into silica nanonetwork. It was then sequentially decorated with MnO2 photosensitizer chlorin e6 (Ce6) coated poly(ethylene glycol)-folate (PEG-FA)-functionalized polydopamine (PDA) (designated as brusatol/silica@MnO2/Ce6@PDA-PEG-FA). As an generator, can promote ROS production, which not only directly enhances Ce6-mediated PDT but also strengthens PDA-mediated PTT attacking heat shock proteins (HSPs). Particularly, brusatol could efficiently inhibit activation Nrf2 defense pathway under cause glutathione peroxidase 4 (GPX4) ferritin heavy chain (FTH) inactivation, thereby inducing ferroptosis ultimately phototherapeutic effects. By exploiting these features, brusatol/silica@MnO2/Ce6@PDA-PEG-FA exhibited excellent antitumor enhanced both vitro vivo studies. Overall, our work highlights promising against hypoxia- hyperthermia-associated via suppressing system ferroptosis.
Language: Английский
Citations
77
Exploration, Journal Year: 2024, Volume and Issue: 4(3)
Published: Jan. 17, 2024
Abstract Reactive oxygen species play a crucial role in cell signaling pathways during wound healing phases. Treatment strategies to balance the redox level deep tissue are emerging for management. In recent years, reactive scavenging agents including natural antioxidants, (ROS) nanozymes, and antioxidant delivery systems have been widely employed inhibit oxidative stress promote skin regeneration. Here, importance of different phases is critically analyzed. Various cutting‐edge bioactive ROS nanoscavengers platforms discussed. This review also highlights future directions therapies via scavenging. comprehensive offers map research on scavengers with balancing mechanisms action process, which benefits development clinical applications next‐generation scavenging‐based nanomaterials
Language: Английский
Citations
63