Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering DOI Open Access

Fengbo Sun,

Xiaodan Sun,

Hetong Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(10), P. 5831 - 5831

Published: May 23, 2022

Polylactic acid-glycolic acid (PLGA) has been widely used in bone tissue engineering due to its favorable biocompatibility and adjustable biodegradation. 3D printing technology can prepare scaffolds with rich structure function, is one of the best methods obtain for repair. This review systematically summarizes research progress 3D-printed, PLGA-based scaffolds. The properties modified components are introduced detail. influence method change process analyzed. advantages disadvantages their applications illustrated by several examples. Finally, we briefly discuss limitations future development direction current materials

Language: Английский

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects DOI
Pooyan Makvandi, Chenyu Wang, Ehsan Nazarzadeh Zare‬

et al.

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(22)

Published: March 17, 2020

Abstract Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface‐colonized microbes pose serious problems to the society both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or surface materials, by coatings, prevent microbial adhesion kill microorganisms after their attachment biofilms, represents important strategy in increasingly challenging field. Over last decade, many studies have been devoted preparing meta‐based nanomaterials that possess antibacterial, antiviral, antifungal activities combat pathogen‐related diseases. Herein, overview state‐of‐the‐art nanosized metal‐based compounds provided, including metal oxide nanoparticles as well transition nanosheets. The mechanism these nanostructures biomedical applications such catheters, implants, medical delivery systems, tissue engineering, dentistry are discussed. Their properties potential caveats cytotoxicity, diminishing efficacy, induction resistance materials incorporating reviewed provide backdrop for future research.

Language: Английский

Citations

586

Advances in Antimicrobial Microneedle Patches for Combating Infections DOI
Rezvan Jamaledin,

Cynthia Kar Yung Yiu,

Ehsan Nazarzadeh Zare‬

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(33)

Published: June 29, 2020

Abstract Skin infections caused by bacteria, viruses and fungi are difficult to treat conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability drugs infection site, as well lack prolonged release. Emerging antimicrobial transdermal ocular microneedle patches have become promising medical devices for delivery various antibacterial, antifungal, antiviral therapeutics. In present review, skin anatomy its barriers along with discussed. Potential strategies designing microneedles their targeted therapy outlined. Finally, biosensing associated personalized selective toxicity toward specific microbial species

Language: Английский

Citations

356

Carboxymethyl cellulose-based materials for infection control and wound healing: A review DOI

Vimala Kanikireddy,

Kokkarachedu Varaprasad, Tippabattini Jayaramudu

et al.

International Journal of Biological Macromolecules, Journal Year: 2020, Volume and Issue: 164, P. 963 - 975

Published: July 21, 2020

Language: Английский

Citations

348

3D and 4D printing in dentistry and maxillofacial surgery: Printing techniques, materials, and applications DOI
Danial Khorsandi, Amir Fahimipour, Payam Abasian

et al.

Acta Biomaterialia, Journal Year: 2020, Volume and Issue: 122, P. 26 - 49

Published: Dec. 26, 2020

Language: Английский

Citations

298

PLGA-Based Composites for Various Biomedical Applications DOI Open Access
Cátia Vieira Rocha, Victor Gonçalves, Milene Costa da Silva

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 2034 - 2034

Published: Feb. 12, 2022

Polymeric materials have been extensively explored in the field of nanomedicine; within them, poly lactic-co-glycolic acid (PLGA) holds a prominent position micro- and nanotechnology due to its biocompatibility controllable biodegradability. In this review we focus on combination PLGA with different inorganic nanomaterials form nanocomposites overcome polymer’s limitations extend applications. We discuss their physicochemical properties variety well-established synthesis methods for preparation PLGA-based materials. Recent progress design biomedical applications are thoroughly discussed provide framework future research.

Language: Английский

Citations

211

Recent advances in PLGA-based biomaterials for bone tissue regeneration DOI
Shue Jin, Xue Xia, Jinhui Huang

et al.

Acta Biomaterialia, Journal Year: 2021, Volume and Issue: 127, P. 56 - 79

Published: April 6, 2021

Language: Английский

Citations

209

In vivo gene delivery mediated by non-viral vectors for cancer therapy DOI Open Access
Reza Mohammadinejad, Ali Dehshahri, Vijay Sagar Madamsetty

et al.

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 325, P. 249 - 275

Published: July 4, 2020

Language: Английский

Citations

201

4D-Printed Dynamic Materials in Biomedical Applications: Chemistry, Challenges, and Their Future Perspectives in the Clinical Sector DOI Creative Commons

Wenxian Zhou,

Zhiguang Qiao, Ehsan Nazarzadeh Zare‬

et al.

Journal of Medicinal Chemistry, Journal Year: 2020, Volume and Issue: 63(15), P. 8003 - 8024

Published: April 7, 2020

Most of the biomedical materials printed using 3D bioprinting are static and unable to alter/transform with dynamic changes in internal environment body. The emergence four-dimensional (4D) printing addresses this problem. By preprogramming polymer their nanocomposites, 4D is able produce desired shapes or transform functions under specific conditions stimuli better adapt surrounding environment. In review, current potential applications 4D-printed introduced different aspects field, e.g., tissue engineering, drug delivery, sensors. addition, existing limitations possible solutions discussed. Finally, along future perspective presented provide a basis for research.

Language: Английский

Citations

154

Biomedical Applications of MXene‐Integrated Composites: Regenerative Medicine, Infection Therapy, Cancer Treatment, and Biosensing DOI Creative Commons
Aziz Maleki, Matineh Ghomi, Nasser Nikfarjam

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(34)

Published: June 24, 2022

Abstract MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical biological properties, gained much attention in the biomedical field recent years, including drug delivery systems, regenerative medicine, biosensing. Additionally, incorporation into hydrogels has garnered significant interest engineering an electroactive mechanical nanoreinforcer capable converting nonconductive scaffolds excellent conductors electricity with impressive effect on properties for organs tissues such cardiac, skeletal muscle, nerve. However, many questions problems remain unresolved that need be answered usher these materials toward true destiny. Thus, this review paper aims provide overview design applications MXene‐integrated composites applications, cardiac tissue engineering, wound healing, infection therapy, cancer biosensors. Moreover, current challenges limitations utilizing vivo are highlighted discussed, followed by its prospects guideline possible various futuristic applications. This article will inspire researchers, who search opportunities, using nanomaterial

Language: Английский

Citations

140

Electroconductive multi-functional polypyrrole composites for biomedical applications DOI
Ehsan Nazarzadeh Zare‬, Tarun Agarwal, Atefeh Zarepour

et al.

Applied Materials Today, Journal Year: 2021, Volume and Issue: 24, P. 101117 - 101117

Published: July 16, 2021

Language: Английский

Citations

108