International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(10), P. 5831 - 5831
Published: May 23, 2022
Polylactic
acid-glycolic
acid
(PLGA)
has
been
widely
used
in
bone
tissue
engineering
due
to
its
favorable
biocompatibility
and
adjustable
biodegradation.
3D
printing
technology
can
prepare
scaffolds
with
rich
structure
function,
is
one
of
the
best
methods
obtain
for
repair.
This
review
systematically
summarizes
research
progress
3D-printed,
PLGA-based
scaffolds.
The
properties
modified
components
are
introduced
detail.
influence
method
change
process
analyzed.
advantages
disadvantages
their
applications
illustrated
by
several
examples.
Finally,
we
briefly
discuss
limitations
future
development
direction
current
materials
Bioengineering,
Journal Year:
2020,
Volume and Issue:
7(3), P. 91 - 91
Published: Aug. 10, 2020
Prostate
cancer
(PCa)
accounts
for
a
high
number
of
deaths
in
males
with
no
available
curative
treatments.
Patients
PCa
are
commonly
diagnosed
advanced
stages
due
to
the
lack
symptoms
early
stages.
Recently,
research
focus
was
directed
toward
gene
editing
therapy.
Small
interfering
RNA
(siRNA)
intervention
is
considered
as
powerful
tool
silencing
(knockdown),
enabling
suppression
oncogene
factors
cancer.
This
strategy
applied
treatment
various
cancers
including
PCa.
The
siRNA
can
inhibit
proliferation
and
invasion
cells
able
promote
anti-tumor
activity
chemotherapeutic
agents.
However,
off-target
effects
therapy
remarkably
reduce
its
efficacy
To
date,
carriers
were
designed
improve
delivery
and,
among
them,
nanoparticles
importance.
Nanoparticles
enable
targeted
siRNAs
enhance
their
potential
downregulation
target
genes
interest.
Additionally,
provide
platform
co-delivery
drugs,
resulting
decreased
growth
migration
cells.
efficacy,
specificity,
comprehensively
discussed
this
review
direct
further
studies
using
nanoscale-delivery
systems
perhaps
other
types.
Small Science,
Journal Year:
2021,
Volume and Issue:
1(5)
Published: March 4, 2021
NH
3
plays
an
indispensable
role
in
agriculture,
fertilizer
production
as
well
the
chemical
industry.
However,
its
large‐scale
still
relies
deeply
on
century‐old
Haber–Bosch
process
under
high
temperature
and
pressure
along
with
greenhouse
gas
emission
fossil
fuel
consumption.
The
electrocatalytic
photocatalytic
N
2
reduction
reactions
(NRRs)
for
are
favorable
approaches
to
avoid
these
issues
because
they
carbon‐neutral
energy‐saving.
Recently,
nonprecious
metal
oxides
(NPMO)
have
gathered
most
attention
due
their
ease
of
synthesis,
controllable
stability,
lower
cost,
environmental
friendliness.
Herein,
recent
advances
NPMO
electrocatalysts
photocatalysts
NRR
narrated
strategies
improve
poor
activity
pristine
NPMOs
by
heteroatom
doping
engineer
surface‐active
sites
introduction
oxygen
vacancies
highlighted.
A
brief
summary
future
perspective
this
research
field
also
presented.
Journal of Controlled Release,
Journal Year:
2021,
Volume and Issue:
338, P. 253 - 267
Published: Aug. 19, 2021
Exosomes
are
naturally
secreted
nanovesicles
that
have
emerged
as
a
promising
therapeutic
nanodelivery
platform
due
to
their
specific
composition,
biological
properties,
and
stability.
Modifying
synthetic
nanoparticles
with
the
intrinsic
hallmarks
of
exosome
membrane
create
mimetics
could
lead
safe
efficient
smart
silencer
delivery.The
study
focuses
on
exploring
combination
polylactic-co-glycolic
acid
(PLGA)-based
occurring
from
M2
macrophages
deliver
Dnmt3aos
treat
allergic
asthma
(AA)
in
mice.Exosome
PLGA
(PLGA
NPs)
wrapped
(Dnmt3aossmart
silencer)
were
first
synthesized.
The
resulting
coated
PLGA@Dnmt3aossmart
(EM-PLGA@Dnmt3aossmart
was
administered
intravenously
into
Der
f1-induced
mice,
which
followed
by
investigation
outcomes
mechanism
vivo.Seven
infusions
EM-PLGA@Dnmt3aossmart
ameliorated
AA
marked
reduction
lung
inflammation.
After
intravenous
injection,
distributed
various
organs,
including
lungs,
retention
over
48
h,
it
targeted
macrophages.
Moreover,
injections
markedly
decreased
proportion
inflammatory
cytokines
airway.
More
importantly,
treatment
did
not
obviously
suppress
overall
immune
function
host.To
our
knowledge,
this
provides
experimental
evidence
ability
target
combining
biomaterials,
thus
presenting
novel
immunotherapy
for
disease.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(10), P. 5831 - 5831
Published: May 23, 2022
Polylactic
acid-glycolic
acid
(PLGA)
has
been
widely
used
in
bone
tissue
engineering
due
to
its
favorable
biocompatibility
and
adjustable
biodegradation.
3D
printing
technology
can
prepare
scaffolds
with
rich
structure
function,
is
one
of
the
best
methods
obtain
for
repair.
This
review
systematically
summarizes
research
progress
3D-printed,
PLGA-based
scaffolds.
The
properties
modified
components
are
introduced
detail.
influence
method
change
process
analyzed.
advantages
disadvantages
their
applications
illustrated
by
several
examples.
Finally,
we
briefly
discuss
limitations
future
development
direction
current
materials
