Surgical Bioengineering of the Microvasculature and Challenges in Clinical Translation DOI

Kevin Schlidt,

Mohamadhossein Asgardoon,

David A. Febre-Alemañy

et al.

Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Tissue and organ dysfunction are major causes of worldwide morbidity mortality with all medical specialties being impacted. engineering is an interdisciplinary field relying on the combination scaffolds, cells, biologically active molecules to restore form function. However, clinical translation still largely hampered by limitations in vascularization. Consequently, a thorough understanding microvasculature warranted. This review provides overview (1) angiogenesis, including sprouting intussusceptive vascular remodeling, co-option, inosculation; (2) strategies for vascularized engineered tissue fabrication such as scaffold modulation, prevascularization, growth factor utilization, cell-based approaches; (3) guided microvascular development via modulation electromechanical cues, 3D bioprinting, electrospinning; (4) surgical approaches bridge micro- macrovasculatures order hasten perfusion; (5) building specific vasculature context repair transplantation, skin, adipose, bone, liver, kidney, lung. Our goal provide reader translational that spans developmental biology, engineering, surgery.

Language: Английский

Properties of Poly (Lactic-co-Glycolic Acid) and Progress of Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Materials in Biomedical Research DOI Creative Commons
Yue Lü, Dongfang Cheng, Ben Niu

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 454 - 454

Published: March 17, 2023

In recent years, biodegradable polymers have gained the attention of many researchers for their promising applications, especially in drug delivery, due to good biocompatibility and designable degradation time. Poly (lactic-co-glycolic acid) (PLGA) is a functional polymer made from polymerization lactic acid (LA) glycolic (GA) widely used pharmaceuticals medical engineering materials because its biocompatibility, non-toxicity, plasticity. The aim this review illustrate progress research on PLGA biomedical as well shortcomings, provide some assistance future development.

Language: Английский

Citations

99
3D printing of biodegradable polymers and their composites – Current state-of-the-art, properties, applications, and machine learning for potential future applications DOI Creative Commons
S. A. V. Dananjaya, Venkata S. Chevali, John P. Dear

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 146, P. 101336 - 101336

Published: July 9, 2024

This review paper comprehensively examines the dynamic landscape of 3D printing and Machine Learning utilizing biodegradable polymers their composites, presenting a panoramic synthesis research developments, technological achievements, emerging applications. By investigating multitude polymer types, delineates suitability compatibility with diverse methodologies demonstrates merit machine learning techniques, in future manufacturing processes. Moreover, this focuses on intricacies material preparation, design adaptation as well post-processing techniques tailored for polymers, elucidating pivotal role achieving structural integrity functional excellence. From biomedical implants sustainable packaging solutions to artistic creations, unveils expansive spectrum practical implementations, thus portraying multifaceted impact technology. Whilst outlining prevalent challenges such mechanical properties recycling, concurrently surveys ongoing endeavors aimed at addressing these limitations. In essence, encapsulates transformative potential providing roadmap advancements underscoring its fostering manufacturing/consumption future.

Language: Английский

Citations

28
Wireless Battery-free and Fully Implantable Organ Interfaces DOI
A. K. Bhatia, Jessica Hanna, Tucker Stuart

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2205 - 2280

Published: Feb. 21, 2024

Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting a new generation of fully implantable organ interfaces that leverage volumetric reduction mechanics by eliminating electrochemical storage. This device class offers the ability to provide high-fidelity readouts physiological processes, enables stimulation, allows control over organs realize therapeutic diagnostic paradigms. Driven seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key advances carefully designed material, electrophysical, electrochemical, electromagnetic systems form implantables mechanical properties closely matched target deliver functionality supports sensors stimulators. The elimination operation, anywhere from acute, lifetimes matching subject physical dimensions imperceptible operation. review provides comprehensive overview basic building blocks related topics such as implantation, delivery, sterilization, user acceptance. State art examples categorized system an outlook interconnection advanced strategies for computation leveraging consistent influx elevate this current battery-powered is highlighted.

Language: Английский

Citations

18
Application and progress of 3D printed biomaterials in osteoporosis DOI Creative Commons
Chenxu Wang, Aiguo Liu, Ziwen Zhao

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 4, 2025

Osteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and formation. Conventional treatments, such as pharmaceutical drugs hormone replacement therapy, often yield suboptimal are frequently associated with side effects. Recently, biomaterial-based approaches have gained attention promising alternatives for managing osteoporosis. This review summarizes the current advancements 3D-printed biomaterials designed osteoporosis treatment. The benefits of compared to traditional systemic drug therapies discussed. These materials can be broadly categorized based on their functionalities, including promoting osteogenesis, reducing inflammation, exhibiting antioxidant properties, inhibiting osteoclast activity. 3D printing has advantages speed, precision, personalization, etc. It is able satisfy requirements irregular geometry, differentiated composition, multilayered structure articular osteochondral scaffolds boundary layer structure. limitations existing critically analyzed future directions considered.

Language: Английский

Citations

2
3D printing of inorganic-biopolymer composites for bone regeneration DOI Creative Commons
D. van der Heide, Gianluca Cidonio, Martin J. Stoddart

et al.

Biofabrication, Journal Year: 2022, Volume and Issue: 14(4), P. 042003 - 042003

Published: Aug. 25, 2022

In most cases, bone injuries heal without complications, however, there is an increasing number of instances where healing needs major clinical intervention. Available treatment options have severe drawbacks, such as donor site morbidity and limited availability for autografting. Bone graft substitutes containing growth factors would be a viable alternative, however they been associated with dose-related safety concerns lack control over spatial architecture to anatomically match defect sites. A 3D printing offers solution produce patient specific that are customized the temporal incorporated therapeutics maximize their efficacy. Inspired by natural constitution tissue, composites made inorganic phases, nanosilicate particles, calcium phosphate, bioactive glasses, combined biopolymer matrices investigated building blocks biofabrication constructs. Besides capturing elements physiological structure, these inorganic/organic can designed cohesivity, rheological mechanical properties, while both organic constituents contribute composite bioactivity. This review provides overview printed biomaterial-inks tissue engineering. Furthermore, key aspects in biomaterial-ink design, techniques, summarized.

Language: Английский

Citations

44
Antibacterial 3D-Printed Silver Nanoparticle/Poly Lactic-Co-Glycolic Acid (PLGA) Scaffolds for Bone Tissue Engineering DOI Open Access

Fajun Chen,

Jian Han,

Zeyong Guo

et al.

Materials, Journal Year: 2023, Volume and Issue: 16(11), P. 3895 - 3895

Published: May 23, 2023

Infectious bone defects present a major challenge in the clinical setting currently. In order to address this issue, it is imperative explore development of tissue engineering scaffolds that are equipped with both antibacterial and regenerative capabilities. study, we fabricated using silver nanoparticle/poly lactic-co-glycolic acid (AgNP/PLGA) material via direct ink writing (DIW) 3D printing technique. The scaffolds' microstructure, mechanical properties, biological attributes were rigorously assessed determine their fitness for repairing defects. surface pores AgNPs/PLGA uniform, AgNPs evenly distributed within scaffolds, as confirmed scanning electron microscopy (SEM). Tensile testing addition enhanced strength scaffolds. release curves ions released them continuously after an initial burst. growth hydroxyapatite (HAP) was characterized SEM X-ray diffraction (XRD). results showed HAP deposited on also had mixed AgNPs. All containing exhibited properties against Staphylococcus aureus (S. aureus) Escherichia coli (E. coli). A cytotoxicity assay mouse embryo osteoblast precursor cells (MC3T3-E1) excellent biocompatibility could be used tissue. study shows have exceptional biocompatibility, effectively inhibiting S. E. coli. These demonstrate potential application 3D-printed engineering.

Language: Английский

Citations

25
Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations DOI Creative Commons
Sara Abtahi, Xiaohu Chen, Sima Shahabi

et al.

ACS Materials Au, Journal Year: 2023, Volume and Issue: 3(5), P. 394 - 417

Published: June 23, 2023

Lack of horizontal and vertical bone at the site an implant can lead to significant clinical problems that need be addressed before treatment take place. Guided regeneration (GBR) is a commonly used surgical procedure employs barrier membrane encourage growth new tissue in areas where has been lost due injury or disease. It promising approach achieve desired repair widely accepted approximately 40% patients with defects. In this Review, we provide comprehensive examination recent advances resorbable membranes for GBR including natural materials such as chitosan, collagen, silk fibroin, along synthetic polyglycolic acid (PGA), polycaprolactone (PCL), polyethylene glycol (PEG), their copolymers. addition, properties these foreign body reaction, mechanical stability, antibacterial property, factor delivery performance will compared discussed. Finally, future directions development potential applications highlighted.

Language: Английский

Citations

23
Green engineered biomaterials for bone repair and regeneration: Printing technologies and fracture analysis DOI
Balbina Makurat‐Kasprolewicz, Hossein Ipakchi,

Pouya Rajaee

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 152703 - 152703

Published: June 5, 2024

Language: Английский

Citations

10
Surface Modification Progress for PLGA-Based Cell Scaffolds DOI Open Access

Bohua Yan,

Yabing Hua, Jinyue Wang

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(1), P. 165 - 165

Published: Jan. 4, 2024

Poly(lactic-glycolic acid) (PLGA) is a biocompatible bio-scaffold material, but its own hydrophobic and electrically neutral surface limits application as cell scaffold. Polymer materials, mimics ECM organic material have often been used coating materials for PLGA scaffolds to improve the poor adhesion of enhance tissue adaptation. These can be modified on via simple physical or chemical methods, multiple simultaneously confer different functions scaffold; not only does this ensure stronger it also modulates behavior function. This approach could facilitate production more PLGA-based scaffolds. review focuses surface-modified applications, will provide guidance modification.

Language: Английский

Citations

9
Shape/properties collaborative intelligent manufacturing of artificial bone scaffold: structural design and additive manufacturing process DOI
Pei Feng, Lingxi Liu, Feng Yang

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 17(1), P. 012005 - 012005

Published: Nov. 8, 2024

Abstract Artificial bone graft stands out for avoiding limited source of autograft as well susceptibility to infection allograft, which makes it a current research hotspot in the field defect repair. However, traditional design and manufacturing method cannot fabricate scaffold that mimics complicated bone-like shape with interconnected porous structure multiple properties akin human natural bone. Additive manufacturing, can achieve implant’s tailored external contour controllable fabrication internal microporous structure, is able form almost any designed via layer-by-layer process. As additive promising building artificial scaffold, only combining excellent structural appropriate process produce ideal biological mechanical properties. In this article, we sum up analyze state art methods realize shape/properties collaborative intelligent manufacturing. Scaffold be mainly classified into based on unit cells whole while basic 3D bioprinting are recommended suitable fabrication. The challenges future perspectives manufactured also discussed.

Language: Английский

Citations

9