Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
8, P. 101622 - 101622
Published: June 1, 2024
Schiff
bases
are
crucial
intermediates
in
organic
chemistry.
They
used
to
introduce
carbon–nitrogen
double
bonds
molecules.
In
this
study,
4-(2-hydroxyanilino)
pent-3-in-2-one
(L)
was
synthesized
from
the
reaction
of
2,4-pentanedione
and
2-aminophenol.
The
structure
L
confirmed
through
analytical
spectroscopic
data.
addition,
its
thermal
stability
examined
using
thermogravimetric
differential
analysis.
gas
phase,
investigations
highest
occupied
molecular
orbital
(HOMO)
lowest
unoccupied
(LUMO)
revealed
an
energy
gap
(ΔE)
3.9304
eV.
antioxidant
capacity
assessed
various
techniques,
including
hydroxyl
radical
scavenging,
scavenging
2,2-diphenyl-1-picrylhydrazyl
(DPPH),
β-carotene
bleaching,
2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic
acid
(ABTS).
base
displayed
significant
activity,
with
a
half-maximal
inhibitory
concentration
(IC50)
19.8
µg/mL
DPPH
assay,
0.14
ABTS
59.6
μg/mL
assay.
bioactivity
by
DFT
MEP
analysis
indicates
reactivity
nitrogen
oxygen
atoms.
Docking
studies
wave
function
analyses
were
conducted
provide
further
insights
into
compound's
potential
applications
pharmaceutical
field.
Nanoscale Advances,
Journal Year:
2023,
Volume and Issue:
5(23), P. 6594 - 6605
Published: Jan. 1, 2023
In
this
research,
a
novel
nanomagnetic
tetra-azamacrocyclic
Schiff
base
complex
of
copper(ii)
was
produced
via
post-synthetic
surface
modification
an
Fe3O4
by
silane-coupling
agent
that
contains
acetylacetone
functionalities
at
the
end
its
chain.
Moreover,
target
Cu
involves
tetradentate
ligand
obtained
from
template
reaction
with
o-phenylenediamine
and
Cu(NO3)2·3H2O.
Furthermore,
prepared
nominated
as
[Fe3O4@TAM-Schiff-base-Cu(II)].
The
Fourier-transform
infrared
(FT-IR)
analysis
indicates
presence
Schiff-base-Cu
in
catalyst.
X-ray
spectroscopy
(EDS)
TGA
reveal
approximately
6-7%
catalyst
comprises
hydrocarbon
moieties.
scanning
electron
microscope
(SEM)
transmission
microscopy
(TEM)
images
demonstrate
uniformly
shaped
particles,
nearly
spherical
nature,
sizes
ranging
9
to
18
nm.
[Fe3O4@TAM-Schiff-base-Cu(II)]
applied
for
click
synthesis
diverse
range
5-substituted-1H-tetrazoles
PEG-400
green
medium.
Regarding
electrical
properties
Cu(ii)
complex,
tetra-aza
(N4
donor)
macrocyclic
N-rich
reasonable
-
leading
excellent
capacity
catalyze
these
organic
transformations.
Finally,
high
magnetization
value
(44.92
emu
g-1)
enables
recycling
least
four
times
without
compromising
catalytic
efficiency.
Nano Letters,
Journal Year:
2023,
Volume and Issue:
23(11), P. 5381 - 5390
Published: March 30, 2023
Intranasal
administration
was
previously
proposed
for
delivering
drugs
central
nervous
system
(CNS)
diseases.
However,
the
delivery
and
elimination
pathways,
which
are
very
imperative
to
know
exploring
therapeutic
applications
of
any
given
CNS
drugs,
remain
far
from
clear.
Because
lipophilicity
has
a
high
priority
in
design
as-prepared
tend
form
aggregates.
Therefore,
PEGylated
Fe3O4
nanoparticle
labeled
with
fluorescent
dye
prepared
as
model
drug
studied
elucidate
pathways
intranasally
administered
nanodrugs.
Through
magnetic
resonance
imaging,
distribution
nanoparticles
investigated
vivo.
ex
vivo
fluorescence
imaging
microscopy
studies,
more
precise
across
entire
brain
disclosed.
Moreover,
cerebrospinal
fluid
carefully
studied.
The
temporal
dose
levels
delivered
nanodrugs
different
parts
were
also
investigated.
Chemosensors,
Journal Year:
2023,
Volume and Issue:
11(10), P. 533 - 533
Published: Oct. 10, 2023
Biosensors
are
analytical
devices
that
use
biological
interactions
to
detect
and
quantify
single
molecules,
clinical
biomarkers,
contaminants,
allergens,
microorganisms.
By
coupling
bioreceptors
with
transducers,
such
as
nucleic
acids
or
proteins,
biosensors
convert
into
electrical
signals.
Electrochemical
optical
transductions
the
most
widely
used
methods
due
their
high
detection
capability
compatibility
miniaturization.
valuable
in
chemistry,
especially
for
health
diagnostics,
they
offer
simplicity
sensitivity.
Despite
usefulness,
challenges
persist
immobilizing
biorecognition
elements
on
transducer
surface,
leading
issues
loss
of
sensitivity
selectivity.
To
address
these
problems,
introduction
nanomaterials,
particular
magnetic
nanoparticles
(MNPs)
beads,
has
been
implemented.
MNPs
combine
properties
other
interesting
characteristics,
small
size,
surface-to-volume
ratio,
easy
handling,
excellent
biocompatibility,
resulting
improved
specificity
reduced
matrix
effects.
They
can
be
tailored
specific
applications
have
extensively
various
fields,
including
biosensing
diagnosis.
In
addition,
simplify
sample
preparation
by
isolating
target
analytes
via
separation,
thus
reducing
analysis
time
interference
phenomena
improving
performance
detection.
The
synthesis
modification
play
a
crucial
role
adjusting
different
applications.
This
review
presents
an
overview
surface
modifications
contributions
development
bioassays
across
areas.
future
MNP
integration
assays
focused
stability,
multiplex
detection,
simplification
portability
test
platforms,
vivo
applications,
among
areas
development.
International Journal of Numerical Methods for Heat & Fluid Flow,
Journal Year:
2024,
Volume and Issue:
34(9), P. 3355 - 3368
Published: July 5, 2024
Purpose
Enzymes
play
a
pivotal
role
in
orchestrating
essential
biochemical
processes
and
influencing
various
cellular
activities
tissue.
This
paper
aims
to
provide
the
process
of
enzyme
diffusion
within
tissue
matrix
enhance
nano
system
performance
by
means
effectiveness
enzymatic
functions.
The
phenomena
are
also
documented,
providing
chemical
insights
into
complex
governing
movement.
Design/methodology/approach
A
computational
analysis
is
used
develop
simulate
an
optimal
control
model
using
numerical
algorithms,
systematically
regulating
concentrations
scaffold.
Findings
accompanying
videographic
footages
offer
detailed
dynamic
complexity
system,
enriching
reader’s
understanding.
comprehensive
exploration
not
only
contributes
valuable
knowledge
field
but
advances
engineering
biomimetic
systems.
work
linked
biomolecular
structures
dynamics,
offering
understanding
how
these
elements
influence
functions,
ultimately
bridging
gap
between
theoretical
practical
implications.
Originality/value
predictive
for
nanozyme
that
describes
reaction
dynamics
with
catalysts
yet
available
existing
literature.
Colloids and Surfaces A Physicochemical and Engineering Aspects,
Journal Year:
2024,
Volume and Issue:
702, P. 135117 - 135117
Published: Aug. 22, 2024
In
this
study,
an
alternative
mixed
hydro-solvothermal
route
has
been
investigated
for
the
synthesis
of
magnetic
iron
oxide
nanoparticles
with
anisotropic
shape.
The
was
performed
at
mild
conditions
(150
°C)
in
a
water/2-propanol
environment,
using
poly(ethylene
glycol)
(PEG400)
as
structure
directing
agent,
sodium
thiosulfate
reducing
and
NaOH
precipitating
agent.
resulting
systems
were
characterized
by
combining
morphological,
structural,
techniques.
Experimental
results
clearly
demonstrate
that
magnetite/maghemite
nanorods
are
preferentially
obtained
water/PEG400
whereas
2-propanol/PEG400
environment
promotes
growth
polyhedral
systems.
Interestingly,
(i.e.,
water/2-propanol)
favors
preferential
hematite
phase.
