Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155747 - 155747
Published: Nov. 28, 2024
Language: Английский
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(9), P. 4469 - 4494
Published: Sept. 9, 2024
Lung cancer remains a global health concern, demanding the development of noninvasive, prompt, selective, and point-of-care diagnostic tools. Correspondingly, breath analysis using nanobiosensors has emerged as promising noninvasive nose-on-chip technique for early detection lung through monitoring diversified biomarkers such volatile organic compounds/gases in exhaled breath. This comprehensive review summarizes state-of-the-art breath-based diagnosis employing chemiresistive-module supported by theoretical findings. It unveils fundamental mechanisms biological basis biomarker generation associated with cancer, technological advancements, clinical implementation nanobiosensor-based analysis. explores merits, challenges, potential alternate solutions implementing these settings, including standardization, biocompatibility/toxicity analysis, green sustainable technologies, life-cycle assessment, scheming regulatory modalities. highlights nanobiosensors' role facilitating precise, real-time, on-site leading to improved patient outcomes, enhanced management, remote personalized monitoring. Additionally, integrating biosensors artificial intelligence, machine learning, Internet-of-things, bioinformatics, omics technologies is discussed, providing insights into prospects intelligent sniffing nanobiosensors. Overall, this consolidates knowledge on breathomic biosensor-based screening, shedding light its significance applications advancing medical diagnostics reduce burden hospitals save human lives.
Language: Английский
Citations
28
RSC Advances, Journal Year: 2024, Volume and Issue: 14(42), P. 30807 - 30829
Published: Jan. 1, 2024
Modified exosomes are a smart tool for the upcoming precision cancer therapeutic era.
Language: Английский
Citations
9
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489
Published: Feb. 3, 2025
Language: Английский
Citations
1
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7076 - 7087
Published: Nov. 4, 2024
Extracellular vesicles (EVs) are cellular communication molecules and classified into three major subpopulations, such as microvesicles, apoptotic bodies, exosomes. Among these, exosomes-based cancer research is a cutting-edge investigation approach to understanding. During progression , tumor-derived exosomes can reprogram the system promote cancer. Circulating in body fluids blood, plasma, serum, saliva, CSF, sweat, tears play key role identifying diagnostic prognostic biomarkers. Diverse therapeutic sources of including stem cells, plants, immune etc. exhibit significant cancer-healing properties. Although cancer-targeting immunotherapy an effective strategy, it has limitations toxicity, high costs. In comparison, cell-derived cell-free for treatment advantages like less biocompatibility, reduced immunogenicity, efficient, target-specific development. This review highlights signature treatment.
Language: Английский
Citations
4
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
As we progress into the 21st century, cancer stands as one of most dreaded diseases. With approximately in every four individuals facing a lifetime risk developing cancer, remains serious health challenges worldwide. Its multifaceted nature makes it an arduous and tricky problem to diagnose treat. Over years, researchers have explored plenty approaches avenues improve management. One notable strategy includes study extracellular vesicles (EVs) potential biomarkers therapeutics. Among these EVs, exosomes emerged particularly promising candidates due their unique characteristic properties functions. They are small membrane-bound secreted by cells carrying cargo biomolecules such proteins, nucleic acids, lipids. These play crucial roles intercellular communication, facilitating transfer biological information between cell-to-cell communication. Exosomes transport cargoes DNA, RNA, lipids involved cellular reprogramming promoting cancer. In this review, explore molecular composition exosomes, significance chemistry development, its theranostic application well research complications solutions.
Language: Английский
Citations
0
Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 25, 2025
Language: Английский
Citations
0
Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)
Published: April 24, 2025
Language: Английский
Citations
0
Gene, Journal Year: 2024, Volume and Issue: 925, P. 148601 - 148601
Published: May 23, 2024
Language: Английский
Citations
2
Sustainable Food Technology, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Fruit exosomes are the source of natural cancer therapeutic tools.
Language: Английский
Citations
2
Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(4)
Published: June 27, 2024
Abstract Preeclampsia, a hypertensive disorder of pregnancy, poses significant risks to maternal and fetal health. Recent research highlights the potential vertical circulating exosomes (VCEs) as biomarkers for early detection monitoring preeclampsia. Exosomes, small extracellular vesicles involved in intercellular communication, carry bioactive molecules that are messengers parental cell status (healthy or undergoing any pathological condition). In preeclampsia, alterations cargo VCEssuch proteins, lipids, nucleic acids play role pathophysiology complications. These exosomal contents can provide insights into underlying mechanisms, including endothelial dysfunction, immune response dysregulation, placental abnormalities. Early identification specific may facilitate timely therapeutic interventions, improving outcomes both mother child. This article explores emerging VCEs emphasizing their diagnostic prognostic potential, underscores need further validate these integrate them clinical practice.
Language: Английский
Citations
1