Exosomes and Tumor Virus Interlink: A Complex Side of Cancer DOI

Ibrahim S. Topiwala,

Aparna Ramachandran, Antoine Gavoille

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155747 - 155747

Published: Nov. 28, 2024

Language: Английский

Nose-on-Chip Nanobiosensors for Early Detection of Lung Cancer Breath Biomarkers DOI Creative Commons
Vishal Chaudhary, Bakr Ahmed Taha,

Lucky Lucky

et al.

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(9), P. 4469 - 4494

Published: Sept. 9, 2024

Lung cancer remains a global health concern, demanding the development of noninvasive, prompt, selective, and point-of-care diagnostic tools. Correspondingly, breath analysis using nanobiosensors has emerged as promising noninvasive nose-on-chip technique for early detection lung through monitoring diversified biomarkers such volatile organic compounds/gases in exhaled breath. This comprehensive review summarizes state-of-the-art breath-based diagnosis employing chemiresistive-module supported by theoretical findings. It unveils fundamental mechanisms biological basis biomarker generation associated with cancer, technological advancements, clinical implementation nanobiosensor-based analysis. explores merits, challenges, potential alternate solutions implementing these settings, including standardization, biocompatibility/toxicity analysis, green sustainable technologies, life-cycle assessment, scheming regulatory modalities. highlights nanobiosensors' role facilitating precise, real-time, on-site leading to improved patient outcomes, enhanced management, remote personalized monitoring. Additionally, integrating biosensors artificial intelligence, machine learning, Internet-of-things, bioinformatics, omics technologies is discussed, providing insights into prospects intelligent sniffing nanobiosensors. Overall, this consolidates knowledge on breathomic biosensor-based screening, shedding light its significance applications advancing medical diagnostics reduce burden hospitals save human lives.

Language: Английский

Citations

32
Biomolecule-based engineered nanoparticles for Cancer Theranostics DOI

Narayanan Parthasarathy,

Ramar Thangam, Babu Rithisa

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

Citations

3
Landscape of exosomes to modified exosomes: a state of the art in cancer therapy DOI Creative Commons

Divya Mirgh,

Swarup Sonar,

Srestha Ghosh

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(42), P. 30807 - 30829

Published: Jan. 1, 2024

Modified exosomes are a smart tool for the upcoming precision cancer therapeutic era.

Language: Английский

Citations

11
Clinical Impact of Exosome Chemistry in Cancer DOI

Shrishti Madhan,

Rajib Dhar, Arikketh Devi

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

As we progress into the 21st century, cancer stands as one of most dreaded diseases. With approximately in every four individuals facing a lifetime risk developing cancer, remains serious health challenges worldwide. Its multifaceted nature makes it an arduous and tricky problem to diagnose treat. Over years, researchers have explored plenty approaches avenues improve management. One notable strategy includes study extracellular vesicles (EVs) potential biomarkers therapeutics. Among these EVs, exosomes emerged particularly promising candidates due their unique characteristic properties functions. They are small membrane-bound secreted by cells carrying cargo biomolecules such proteins, nucleic acids, lipids. These play crucial roles intercellular communication, facilitating transfer biological information between cell-to-cell communication. Exosomes transport cargoes DNA, RNA, lipids involved cellular reprogramming promoting cancer. In this review, explore molecular composition exosomes, significance chemistry development, its theranostic application well research complications solutions.

Language: Английский

Citations

1
Immune Cell-Derived Exosomes: A Cell-Free Cutting-Edge Tumor Immunotherapy DOI
Raj Sengupta,

Ibrahim S. Topiwala,

Antoine Gavoille

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7076 - 7087

Published: Nov. 4, 2024

Extracellular vesicles (EVs) are cellular communication molecules and classified into three major subpopulations, such as microvesicles, apoptotic bodies, exosomes. Among these, exosomes-based cancer research is a cutting-edge investigation approach to understanding. During progression , tumor-derived exosomes can reprogram the system promote cancer. Circulating in body fluids blood, plasma, serum, saliva, CSF, sweat, tears play key role identifying diagnostic prognostic biomarkers. Diverse therapeutic sources of including stem cells, plants, immune etc. exhibit significant cancer-healing properties. Although cancer-targeting immunotherapy an effective strategy, it has limitations toxicity, high costs. In comparison, cell-derived cell-free for treatment advantages like less biocompatibility, reduced immunogenicity, efficient, target-specific development. This review highlights signature treatment.

Language: Английский

Citations

5
Unravelling the Role of Biomarker in Cancer Detection: An In-Depth Review DOI
Pıyalı Khamkat,

Arpan Adak,

Soumya Chakraborty

et al.

Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 25, 2025

Language: Английский

Citations

0
Exosome-based cancer vaccine: a cell-free approach DOI
Swarup Sonar, Asmit Das, Ketki Kalele

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 24, 2025

Language: Английский

Citations

0
Functionalized exosomes for targeted therapy in cancer and regenerative medicine: genetic, chemical, and physical modifications DOI Creative Commons

Salar Ghaffari Gabaran,

Navid Ghasemzadeh,

Maryam Rahnama

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: June 4, 2025

Extracellular vesicles (EVs), such as exosomes, have been extensively discovered for their function in various diseases and potential therapeutic properties. In this review, we aimed to describe the roles of functionalized exosomes cancer regenerative medicine. review study, studied numerous articles over past two decades published on application different diseases, well perspectives challenges field. Recent advancements shown that can be used a drug delivery system. However, approach faces low efficiency non-targeting effects. Different methods, including genetic, chemical, physical modifications, are functionalize exosome surfaces address these limitations. some cases, combination modification methods has produce smart exosomes. agents inserted by methods. These effectively deliver target cells. A growing body evidence shows promising therapy They not only cells, inhibiting tumorigenesis, but also efficiently contribute tissue repair regeneration increasing cell proliferation angiogenesis. discuss related studies. addition, regeneration, along with perspectives. Although show results, further studies essential clinical translation

Language: Английский

Citations

0
Role of tumor-derived exosomes mediated immune cell reprograming in cancer DOI
Zening Liu,

Zichao Chen,

Jing Zhang

et al.

Gene, Journal Year: 2024, Volume and Issue: 925, P. 148601 - 148601

Published: May 23, 2024

Language: Английский

Citations

3
Fruit exosomes: a sustainable green cancer therapeutic DOI Creative Commons
Asmit Das, Swarup Sonar, Ketki Kalele

et al.

Sustainable Food Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Fruit exosomes are the source of natural cancer therapeutic tools.

Language: Английский

Citations

2