Biomimetic nanoparticles with red blood cell membranes for enhanced photothermal and immunotherapy for tumors DOI Creative Commons

Liquan Hong,

Jingtao Ye,

Yang Li

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(45), P. 32818 - 32826

Published: Jan. 1, 2024

The alarming escalation in cancer incidence and mortality has thrust into spotlight the quest for groundbreaking therapeutic strategies. Our research delves potential of RDIR780, a novel class biomimetic nanoparticles cloaked red blood cell membranes, to significantly enhance their

Language: Английский

Near-Infrared fluorescent BODIPY dyes: green synthesis, photophysical properties, and their applications in biomedical molecular imaging DOI
Raúl Segovia-Pérez, Marisol Ibarra‐Rodríguez, Blanca M. Muñoz‐Flores

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112740 - 112740

Published: March 1, 2025

Language: Английский

Citations

0
Turning on the Heat by Cocrystal Engineering: The Rise of Organic Charge Transfer Photothermal Cocrystals as an Emerging Therapeutic Frontier in Biomedical Application DOI Creative Commons
Arshad Khan, Rabia Usman,

Shuo Xiang

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

ABSTRACT The field of molecular charge transfer cocrystals (CTCs) has advanced rapidly in recent years, with much work focused on their use optoelectronic devices, photoacoustic imaging, photothermal therapy (PTT), optical waveguides, seawater desalination, and more. Organic CTCs are particular interest because unique phototherapeutic effects phototherapy remarkable imaging capabilities fluorescence, magnetic resonance, further enhancing significance medical applications. However, the biomedicine been limited, few reported biological Hence, there is a growing CT‐derived functional potential contenders for targeted controlled biomedical applications such as bacteria inhibition, cancer eradication, tissue regeneration. This review offers insight into advancements crafting producing CT‐based materials attributes. In addition, it outlines current obstacles future prospects this burgeoning research domain, aiming to propel continued advancement biomaterials toward enhanced utilities. Overall, cocrystal‐based near‐infrared (NIR) have revolutionize wide range technological an active area chemistry, science, nanotechnology.

Language: Английский

Citations

0
Deepened Photodynamic Therapy through Skin Optical Clearing Technology in the Visible Light Window DOI

Yanji Chu,

Wenhui Zhang, Bin Yuan

et al.

Langmuir, Journal Year: 2023, Volume and Issue: 40(1), P. 1007 - 1015

Published: Dec. 20, 2023

The trade-off that shorter wavelength light facilitates the efficient generation of reactive oxygen species (ROS) from photosensitizer (PS) while facing drawback limited penetration depth through skin tissue restricts further development photodynamic therapy (PDT). Here, we address this contradiction and achieve visible-light-tailored deep PDT combined with optical clearing technology. With help prepared gel, refractive index inhomogeneity between components is greatly attenuated, scattering effect within remarkably reduced. As a consequence, transmittance visible at 600 nm

Language: Английский

Citations

7
Self-assembled IR dye/Mitoxantrone loaded Porphysomes Nanosystem for Enhanced Combinatorial Chemo-Photothermal Cancer Therapy DOI
Monika Pebam, Sajmina Khatun, Mohammad Sadik Ali

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 113985 - 113985

Published: May 25, 2024

Language: Английский

Citations

2
Paclitaxel-Loaded PLGA/Au Nanocylinders for the Photothermal-Chemotherapy Treatment of Cancer DOI
Xiang Zhang, Yurui Xu,

Wanyao Chen

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(13), P. 15153 - 15161

Published: June 26, 2024

UV-nanoimprint lithography (UV-NIL) has been proved to be an efficient method for preparing nanodrug delivery systems. Herein, we used UV-NIL associated with the glancing angle deposition (GLAD) process of electron beam evaporation prepare Au-coated PLGA nanocylinders loaded PTX (PTX-PLGA-Au NCs) enhance anticancer efficacy by cooperative treatment photothermal-chemotherapy. PTX-PLGA-Au NCs different length-to-diameter ratios can prepared controlling concentration and regulating GLAD. Upon 808 nm near-infrared (NIR) irradiation, exhibit a stable repeatable photothermal effect. Besides, hyperthermia generated Au layer on surface under laser irradiation promoted rapid release PTX. The in vitro studies demonstrated that achieve synergistic effect photothermal-chemotherapy, leading increased cell cytotoxicity. Therefore, combined GLAD produced promising nanofabrication efficiently developing multifunctional nanoplatform cancer treatment.

Language: Английский

Citations

1
BODIPY photosensitizers for antibacterial photodynamic therapy DOI

Yuyao Guan,

Biao Yu, Jun Ding

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110645 - 110645

Published: Nov. 1, 2024

Language: Английский

Citations

1
Thermo-Responsive Gold Nanorod Vesicles for Combined NIR-II Photothermal Therapy and Chemotherapy of Solid Tumors DOI

Wenqian Xing,

Ting Li, Guangze Yang

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 192, P. 353 - 365

Published: Nov. 26, 2024

Language: Английский

Citations

1
Activatable Molecular Probes With Clinical Promise for NIR‐II Fluorescent Imaging DOI Open Access
Zikang Chen, Yongjie Zhou, Li Li

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract The second near‐infrared window (NIR‐II) fluorescence imaging has been widely adopted in basic scientific research and preclinical applications due to its exceptional spatiotemporal resolution deep tissue penetration. Among the various fluorescent agents, organic small‐molecule fluorophores are considered most promising candidates for clinical translation, owing their well‐defined chemical structures, tunable optical properties, excellent biocompatibility. However, many currently available NIR‐II exhibit an “always‐on” signal, which leads background noise compromises diagnostic accuracy during disease detection. Developing activatable probes (AOSFPs) accurately reporting pathological changes is key advancing toward application. This review summarizes rational design strategies AOSFPs based on four core structures (cyanine, hemicyanine, xanthene, BODIPY). These hold substantial potential translation. Furthermore, recent advances bioimaging comprehensively reviewed, offering clear guidance direction further development. Finally, prospective efforts advance outlined.

Language: Английский

Citations

1
Functionalized Aza-BODIPYs and Their Use in the Synthesis of Aza-BODIPY-Based Complex Systems DOI
Mangalampalli Ravikanth,

Bharti Yadav

Synlett, Journal Year: 2023, Volume and Issue: 35(01), P. 55 - 83

Published: Aug. 17, 2023

Abstract In this account, we present syntheses of various functionalized aza-boron-dipyrromethene dyes (aza-BODIPYs) in which the functional groups are directly introduced at 2- or 6-positions aza-BODIPYs on aryl rings 1-, 3-, 5-, and 7-positions aza-BODIPYs. Some these have been used for synthesis aza-BODIPY-based energy-transfer cassettes light-harvesting complexes. 1 Introduction 2 Monofunctionalized Aza-BODIPYs 2.1 2-/6-Monofunctionalized 2.2 1-/3-/5-/7-Monofunctionalized 3 Difunctionalized Aza-BODIPYs. 3.1 2,6-Difunctionalized 3.2 3,5-Difunctionalized 3.3 1,7-Difunctionalized 4 Miscellaneous 5 Conclusion

Language: Английский

Citations

3
Revolutionary Pyrazole‐based Aza‐BODIPY: Harnessing Photothermal Power Against Cancer Cells and Bacteria DOI
Thitima Pewklang, Worakrit Saiyasombat,

Piyasiri Chueakwon

et al.

ChemBioChem, Journal Year: 2023, Volume and Issue: 25(3)

Published: Dec. 14, 2023

In the realm of cancer therapy and treatment bacterial infection, photothermal (PTT) stands out as a potential strategy. The challenge, however, is to create agents that can perform both imaging PTT, so-called theranostic agent. Photothermal absorb emit in near-infrared region (750-900 nm) have recently received lot attention due extensive penetration NIR light biological tissues. this study, we combined pyrazole with aza-BODIPY (PY-AZB) develop novel PY-AZB demonstrated great photostability conversion efficiency (PCE) up 33 %. Additionally, permeate cells at fast accumulation rate less than 6 hours, according confocal images. Furthermore, vitro results showed effectively eliminated by 70 Interestingly, exhibited antibacterial activities against gram-negative bacteria, Escherichia coli 780, gram-positive Staphylococcus aureus 1466. exhibit satisfactory bactericidal effect killing 100 % upon laser irradiation. As result, may provide viable option for treatment.

Language: Английский

Citations

2