Stimuli-Responsive Polymers at the Interface with Biology

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(9), P. 5417 - 5436

Published: Aug. 28, 2024

There has been growing interest in polymeric systems that break down or undergo property changes response to stimuli. Such polymers can play important roles biological systems, where they be used control the release of therapeutics, modulate imaging signals, actuate movement, direct growth cells. In this Perspective, after discussing most stimuli relevant applications, we will present a selection recent exciting developments. The importance stimuli-responsive polysaccharides discussed, followed by variety for delivery small molecule drugs and nucleic acids. Switchable emerging area therapeutic measurement theranostics described. Then, diverse functions achieved using hydrogels cross-linked covalently, as well various dynamic approaches presented. Finally, discuss some challenges future perspectives field.

Language: Английский

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Iron‐MOFs for Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Over the past two decades, iron-based metal-organic frameworks (Fe-MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite great potential, transition of Fe-MOFs-based composites from laboratory clinical products remains challenging. This review evaluates key properties that distinguish Fe-MOFs other MOFs highlights recent advances synthesis routes, surface engineering, shaping technologies. In particular, it focuses on applications biosensing, antimicrobial, anticancer therapies. addition, emphasizes need develop scalable, environmentally friendly, cost-effective production methods for additional meet specific requirements various biomedical applications. ability combine therapies, hurdles still remain, including a deeper understanding therapeutic mechanisms potential risks resistance overdose. Systematically addressing these challenges could significantly enhance prospects potentially facilitate integration into mainstream practice.

Language: Английский

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Metal-organic framework-based advanced therapeutic tools for antimicrobial applications

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 175, P. 27 - 54

Published: Dec. 17, 2023

The escalating concern over conventional antibiotic resistance has emphasized the urgency in developing innovative antimicrobial agents. In recent times, metal−organic frameworks (MOFs) have garnered significant attention within realm of research due to their multifaceted attributes, including sustained release intrinsic or exogenous components, chemodynamically catalyzed generation reactive oxygen species (ROS), and formation photogenerated ROS. This comprehensive review provides a thorough overview synthetic approaches employed production MOF-based materials, elucidating underlying mechanisms depth. focal point lies advancements across various modalities, encompassing component system, extraneous auto-catalytical energy conversion system. Additionally, progress materials addressing wound infections, osteomyelitis, periodontitis is meticulously elucidated, culminating summary challenges potential opportunities inherent applications for materials. Growing concerns about need alternative solutions. Metal-organic gained diverse attributes like components release, catalytic covers MOF synthesis mechanisms. It explores auto-catalysis, systems. paper also discusses materials' periodontitis, along with existing opportunities. Given lack related reviews, our findings hold promise future antibacterial research, making it relevant your journal's readership.

Language: Английский

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Structure-directing effect of Terephthalate bridging Zn(II)- and Cd(II)-based coordination polymers towards application for the detection of trace quantity of Pd2+ in aqueous medium and their electrical conductivities

Dalton Transactions, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Energy crisis and environmental pollution are two central themes of contemporary research towards achieving sustainable development goals (SDGs).

Language: Английский

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Thermo- and pH-responsive MOF-303 mediated P127 and Gelatin coating for combination drug release and liver cancer therapy

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102548 - 102548

Published: Jan. 30, 2025

Language: Английский

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Solar radiation–promoted selective photocatalytic degradation of Congo red dye by a novel amorphous Cr-based metal-organic framework serving as sensor for 2,4,6-trinitrophenol explosive detection

Environmental Monitoring and Assessment, Journal Year: 2025, Volume and Issue: 197(3)

Published: Feb. 25, 2025

Language: Английский

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Exploring porous hybrid metal–organic framework hydrogel as a potential platform in drug delivery systems

Deleted Journal, Journal Year: 2025, Volume and Issue: 246(1)

Published: March 12, 2025

Language: Английский

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Current research and future potential of thermogels for sustained drug delivery

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Drug administration is ubiquitous in the healthcare field, and it crucial to optimize drug delivery methods improve efficacy, reduce systemic toxicity, enhance patient compliance Thermogels have shown immense potential due their injectability, biocompatibility, ability provide localized sustained release. This paper discusses unique properties of thermogel relation kinetics suitability as a carrier. Different considerations applications systems (DDS) were highlighted challenges enter market discussed. A comprehensive literature search was conducted using major databases such PubMed, Scopus, Web Science. The employed relevant keywords identify studies on DDS. Clinicaltrials.gov also utilized determine current state clinical studies. Nonetheless, holds great promise for future DDS with research achieving greater heights terms complexity pursuits. Their flexibility fabrication modularity manner makes material tailor different be integrated into various biomedical disciplinaries.

Language: Английский

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Carboxylate embedded metal organic frameworks for potential applications in drug delivery and controlled release

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216688 - 216688

Published: April 21, 2025

Language: Английский

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Sustainable Polymeric Biomaterials from Alternative Feedstocks

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(11), P. 6751 - 6765

Published: Oct. 9, 2024

As materials engineered to interact with biological systems for medical purposes, polymeric biomedical have revolutionized and are indispensable in modern healthcare. However, aging populations improving healthcare standards worldwide resulted ever-increasing demands such biomaterials. Currently, many clinically used polymers derived from nonrenewable petroleum resources, thus spurring the need exploring alternatives next generation of sustainable Other than biomass, this Perspective also spotlights carbon dioxide postuse plastics as viable resources potentially suitable biomaterial production. For each alternative feedstock, key recent developments practical considerations discussed, including emerging applications, possible feedstock sources, hindrances toward translation adoption. replacements petroleum-derived polymers, we explore how utilization these capitalizes on their intrinsic physiochemical material properties achieve desired therapeutic effects. We hope that can stimulate further development biomaterials benefits part a circular economy minimal environmental impact.

Language: Английский

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