Novel Use of Magnesium Hydride to Prevent Peritoneal Adhesions by Regulating Inflammation and Oxidative Stress DOI Open Access
Chuchen Gong,

Bohui Li,

Yajie Wang

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract Peritoneal adhesions (PAs) represent a significant clinical challenge, primarily arising from excessive post‐surgical inflammation, which leads to the deposition of fibrin and extracellular matrix, forming adhesive bands that can cause severe complications such as intestinal obstruction infertility. Current therapeutic options offer limited efficacy in preventing or treating PAs, highlighting need for new strategies. To address this issue, magnesium hydride (MgH₂) microparticles capable are developed stable hydrogen (H₂) storage controlled release regulate inflammation promote tissue regeneration. The antioxidant properties, modulation, H₂ profile MgH₂ evaluated vitro, while its anti‐adhesion, angiogenic, regenerative effects assessed vivo using postoperative rat models. These findings demonstrate significantly mitigates inflammatory dysregulation, reduces oxidative stress, effectively prevents peritoneal adhesion formation at wound sites. results suggest offers promising approach PAs supporting beneficial regeneration, presenting potential solution management.

Language: Английский

Bioinspired injectable hydrogels for bone regeneration DOI Creative Commons
Xuan Tang,

Fengjin Zhou,

Sicheng Wang

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

The effective regeneration of bone/cartilage defects remains a significant clinical challenge, causing irreversible damage to millions annually.Conventional therapies such as autologous or artificial bone grafting often yield unsatisfactory outcomes, emphasizing the urgent need for innovative treatment methods. Biomaterial-based strategies, including hydrogels and active scaffolds, have shown potential in promoting regeneration. Among them, injectable garnered substantial attention recent years on account their minimal invasiveness, shape adaptation, controlled spatiotemporal release. This review systematically discusses synthesis hydrogels, bioinspired approaches-covering microenvironment, structural, compositional, bioactive component-inspired strategies-and applications various disease models, highlighting from an perspective design. Taken together, offer promising feasible solutions regeneration, ultimately laying foundations applications. Furthermore, insights into further prospective directions AI screening organoid construction are provided.

Language: Английский

Citations

5
Injectable photosensitive bone cement enhancing angiogenesis and osteogenic differentiation for the treatment of bone nonunion DOI Creative Commons

Mengnan Wen,

Xueqiang Guo, Yan Gong

et al.

APL Bioengineering, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 1, 2025

Nonunion fractures present a significant clinical challenge because of their complex microenvironment, which includes poor vascularization, insufficient osteogenesis, infection, and separation fracture ends. The current treatments have certain limitations. Inspired by this phenomenon, sandcastle worms secrete adhesive proteins that bind sand grains, shell fragments, mineral particles, thereby constructing “castles.” In study, we developed an injectable bone cement using methacryloyl chitosan (CSMA) combined with specific concentration oyster nanoparticles (OS-np) to treat nonunion fractures. Oyster shells are composed primarily calcium carbonate, releases ions promote angiogenesis osteogenesis. in vivo results at 8 weeks showed the expression BMP2, RUNX2, VEGF OS-np/CSMA group was increased 5.47, 4.38, 3.54 times, respectively, compared control group, significantly enhancing vascularization repair model. injectability ensures it can adapt well structures sites, providing supportive matrix for new formation. Both vitro osteogenesis experiments demonstrated enhanced models, synergistic effects ion release bioactive properties nanoparticles. This study highlights potential as promising treatment strategy effectively promotes

Language: Английский

Citations

0
Nanoconfinement of Ammonia Borane via Hybrid‐Phased Titanate Nanocrystals Enables Sustained H2 Release for Diabetic Bone Repair DOI
Yuan Zhang, Fuwei Liu, Minggang Yang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Abstract Despite its potential in hydrogen (H 2 ) therapy, ammonia borane (AB) has limited biomedical applications due to uncontrolled hydrolysis rate and cause cytotoxicity. Existing material‐based delivery strategies focus on accelerating AB for H production, hence exacerbating these issues. A new nanoconfinement strategy is reported, which loads onto oxygen‐deficient, hybrid‐phased titanate nanocrystals implant surfaces through a unique one‐end‐anchored docking (OEAD) mechanism. This effectively restricts the release of molecules, allowing only water molecules infiltrate interlayer space slow sustained release. significantly prolongs duration circumvents cytotoxicity associated with interacting peroxide O inflammatory microenvironment. In vitro vivo have shown that from surface alleviates diabetes‐related oxidative stress, combined magnesium ions (Mg 2+ synergistically promotes innervated‐vascularized bone regeneration.

Language: Английский

Citations

0
Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration DOI
Xiaojun Zhou, Shuo Chen, Andrij Pich

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 11(1), P. 182 - 207

Published: Dec. 12, 2024

The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system microenvironment will result high rate impaired, delayed, or even nonhealing events tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems treat via combination microenvironmental regulation enhanced osteogenic capacity. Following natural healing processes, coupling angiogenesis osteogenesis by advanced bioresponsive drug delivery has proved be significant approach for promoting repair DM. In this Review, we systematically summarized mechanisms strategies DM-induced healing, outlined design systems, highlighted vascularization Accordingly, then overview recent advances developing facilitate vascularized regeneration remodeling modulating multiple regenerative cues. Furthermore, discuss development adaptable with unique features guiding DM-associated future.

Language: Английский

Citations

1
Analysis of the CPZ/Wnt4 osteogenic pathway for high-bonding-strength composite-coated magnesium scaffolds through transcriptomics DOI Creative Commons

Zewen Shi,

Fang Yang,

Tianyu Du

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101234 - 101234

Published: Sept. 8, 2024

Language: Английский

Citations

0
Diabetes mellitus impairs the bone regeneration capacity of mesenchymal stem cell-based therapy DOI
Alann Thaffarell Portilho Souza, Gileade Pereira Freitas, Helena Bacha Lopes

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Abstract BACKGROUND Diabetes mellitus (DM) negatively impacts bone tissue, leading to loss and increased fracture risk with many in need of additional treatments, therapy based on mesenchymal stem cells (MSCs) represents a promising treatment for defects patients diabetes. The present investigation explored the interactions between MSCs from normoglycemic (NG-MSCs) diabetic (DM-MSCs) donors osteoblast differentiation effects NG-MSCs regeneration created rats. METHODS After DM induction streptozotocin, we evaluated morphometric parameters femurs MSC differentiation, as well DM-MSCs differentiation. efficacy cell was measured by evaluating calvarial rats treated local injection either or vehicle. RESULTS induced impaired MSCs, which partially restored NG-MSCs, formation observed vehicle similar. CONCLUSION These findings indicate that beneficial effect did not translate enhanced repair, mostly due hostile environment hyperglycemia, compromises capacity induce formation.

Language: Английский

Citations

0
Novel Use of Magnesium Hydride to Prevent Peritoneal Adhesions by Regulating Inflammation and Oxidative Stress DOI Open Access
Chuchen Gong,

Bohui Li,

Yajie Wang

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Abstract Peritoneal adhesions (PAs) represent a significant clinical challenge, primarily arising from excessive post‐surgical inflammation, which leads to the deposition of fibrin and extracellular matrix, forming adhesive bands that can cause severe complications such as intestinal obstruction infertility. Current therapeutic options offer limited efficacy in preventing or treating PAs, highlighting need for new strategies. To address this issue, magnesium hydride (MgH₂) microparticles capable are developed stable hydrogen (H₂) storage controlled release regulate inflammation promote tissue regeneration. The antioxidant properties, modulation, H₂ profile MgH₂ evaluated vitro, while its anti‐adhesion, angiogenic, regenerative effects assessed vivo using postoperative rat models. These findings demonstrate significantly mitigates inflammatory dysregulation, reduces oxidative stress, effectively prevents peritoneal adhesion formation at wound sites. results suggest offers promising approach PAs supporting beneficial regeneration, presenting potential solution management.

Language: Английский

Citations

0