Toxic effects and involved molecular pathways of nanoparticles on cells and subcellular organelles

Journal of Applied Toxicology, Journal Year: 2019, Volume and Issue: 40(1), P. 16 - 36

Published: July 11, 2019

Abstract Owing to the increasing application of engineered nanoparticles (NPs), besides workplace, human beings are also exposed NPs from nanoproducts through skin, respiratory tract, digestive tract and vein injection. This review states pathways cellular uptake, subcellular distribution excretion NPs. The uptake commonly include phagocytosis, micropinocytosis, clathrin‐ caveolae‐mediated endocytosis, scavenger receptor‐related pathway, or caveolae‐independent direct penetration insertion. Then ability decrease cell viability metabolic activity, change morphology, destroy membrane, cytoskeleton function was presented. In addition, lowest dose decreasing compared with control IC 50 silver, titanium dioxide, zinc oxide, carbon black, nanotubes, silica, silicon cadmium telluride quantum dots some lines gathered. Next, this attempts increase our understanding NP‐caused adverse effects on organelles, which have implications in mitochondrial dysfunction, endoplasmic reticulum stress lysosomal rupture. particular, disturbance biogenesis dynamic fusion‐fission, mitophagy cytochrome c ‐dependent apoptosis involved. prolonged will result apoptosis. Rupture membrane associated inflammation, both induction autophagy blockade autophagic flow can cytotoxicity. Finally, network mechanism combined action multiple organelle apoptosis, oxidative discussed.

Language: Английский

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Theoretical and experimental investigation of visible light responsive AgBiS2-TiO2 heterojunctions for enhanced photocatalytic applications

Applied Catalysis B Environment and Energy, Journal Year: 2019, Volume and Issue: 253, P. 401 - 418

Published: April 20, 2019

Language: Английский

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Genotoxicity assessment of carbon-based nanomaterials; Have their unique physicochemical properties made them double-edged swords?

Mutation Research/Reviews in Mutation Research, Journal Year: 2020, Volume and Issue: 783, P. 108296 - 108296

Published: Jan. 1, 2020

Language: Английский

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Multifunctional Prussian blue-based nanomaterials: Preparation, modification, and theranostic applications

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 419, P. 213393 - 213393

Published: June 8, 2020

Language: Английский

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Nanomaterials: types, properties, recent advances, and toxicity concerns

Current Opinion in Environmental Science & Health, Journal Year: 2021, Volume and Issue: 25, P. 100319 - 100319

Published: Dec. 14, 2021

Language: Английский

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