Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms? DOI Creative Commons
Suchi Smita Gupta, Krishna P. Singh, Shailendra K. Gupta

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(10), P. 1708 - 1708

Published: May 17, 2022

During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are most exploited nanomaterials with global production of around 1000 tons/year. Besides commercial benefits CNTs, fiber-like structures their bio-persistency in lung tissues raise serious concerns about possible adverse human health effects resembling those asbestos fibers. In this review, we present a comparative analysis between CNTs fibers using following four parameters: (1) fibrous needle-like shape, (2) bio-persistent nature, (3) high surface to volume ratio (4) capacity adsorb toxicants/pollutants on surface. We also compare mechanisms underlying toxicity caused by certain diameters lengths downstream pathways associated altered gene expression data from both CNT exposure. Our results suggest that indeed types emulating fiber as far is concerned.

Language: Английский

Synergic effects of nanoparticles-mediated hyperthermia in radiotherapy/chemotherapy of cancer DOI
Keywan Mortezaee, Asghar Narmani, Majid Salehi

et al.

Life Sciences, Journal Year: 2021, Volume and Issue: 269, P. 119020 - 119020

Published: Jan. 13, 2021

Language: Английский

Citations

129
Advances on carbon nanomaterials and their applications in medical diagnosis and drug delivery DOI
Gokul Paramasivam, Vishnu Vardhan Palem,

Simi Meenakshy

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114032 - 114032

Published: June 13, 2024

Language: Английский

Citations

30
From nature to nanomedicine: bioengineered metallic nanoparticles bridge the gap for medical applications DOI Creative Commons
Jitendra Patel, G. Shiva Kumar, Harekrishna Roy

et al.

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 9, 2024

Abstract The escalating global challenge of antimicrobial resistance demands innovative approaches. This review delves into the current status and future prospects bioengineered metallic nanoparticles derived from natural sources as potent agents. unique attributes abundance resources have sparked a burgeoning field research in combating microbial infections. A systematic literature was conducted, encompassing wide range studies investigating synthesis, characterization, mechanisms nanoparticles. Databases such PubMed, Scopus, Web Science, ScienceDirect, Springer, Taylor & Francis online OpenAthen were extensively searched to compile comprehensive overview topic. synthesis methods, including green sustainable approaches, examined, diverse biological used nanoparticle fabrication. amalgamation products has yielded promising Their multifaceted mechanisms, membrane disruption, oxidative stress induction, enzyme inhibition, render them effective against various pathogens, drug-resistant strains. Moreover, potential for targeted drug delivery systems using these opened new avenues personalized medicine. Bioengineered represent dynamic frontier battle underscores their remarkable efficacy action. Future are bright, with opportunities scalability cost-effectiveness through methods. However, addressing toxicity, regulatory hurdles, environmental considerations remains crucial. In conclusion, this highlights evolving landscape nanoparticles, offering valuable insights revolutionize therapy future. Graphical

Language: Английский

Citations

16
Modifying organic carbon in Fe3O4-loaded schwertmannite to improve heterogeneous Fenton activity through accelerating Fe(II) generation DOI
Ting Li, Yanmei Chen, Xiaomeng Wang

et al.

Applied Catalysis B Environment and Energy, Journal Year: 2020, Volume and Issue: 285, P. 119830 - 119830

Published: Dec. 25, 2020

Language: Английский

Citations

85
Fight against COVID-19: The case of antiviral surfaces DOI Creative Commons
Kamyar Shirvanimoghaddam, Mohammad Karbalaei Akbari, Ramdayal Yadav

et al.

APL Materials, Journal Year: 2021, Volume and Issue: 9(3)

Published: March 1, 2021

The COVID-19 pandemic is the largest global public health outbreak in 21st century so far. Based on World Health Organization reports, main source of SARS-CoV-2 infection transmission droplets released when an infected person coughs, sneezes, or exhales. Viral particles can remain air and surfaces for a long time. These are too heavy to float rapidly fall down onto surfaces. To minimize risk infection, entire surrounding environment should be disinfected neutralized regularly. Development antiviral coating surface objects that frequently used by could practical route prevent spread viral inactivation viruses. In this short review, design combat different viruses has been discussed technological attempts minimizing coronavirus have highlighted.

Language: Английский

Citations

75
Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment—A Review DOI Creative Commons
Yvonne Kohl, Elise Rundén‐Pran, Espen Mariussen

et al.

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(10), P. 1911 - 1911

Published: Sept. 25, 2020

Changes in the genetic material can lead to serious human health defects, as mutations somatic cells may cause cancer and contribute other chronic diseases. Genotoxic events appear at both DNA, chromosomal or (during mitosis) whole genome level. The study of mechanisms leading genotoxicity is crucially important, well detection potentially genotoxic compounds. We consider current state art describe here main endpoints applied standard vitro models new advanced 3D that are closer vivo situation. performed a literature review studies published from 2000–2020 (August) dedicated nanomaterials (NMs) models. Methods suitable for NMs will be presented with focus on advances miniaturization, organ-on-a-chip high throughput methods.

Language: Английский

Citations

71
Modified nanofiber containing chitosan and graphene oxide-magnetite nanoparticles as effective materials for smart wound dressing DOI

Seyede Mahtab Hosseini,

Majid Abdouss, Saeedeh Mazinani

et al.

Composites Part B Engineering, Journal Year: 2021, Volume and Issue: 231, P. 109557 - 109557

Published: Dec. 18, 2021

Language: Английский

Citations

63
A Review of in vivo Toxicity of Quantum Dots in Animal Models DOI Creative Commons
Xiaotan Lin,

Tingting Chen

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 8143 - 8168

Published: Dec. 1, 2023

Abstract: Tremendous research efforts have been devoted to nanoparticles for applications in optoelectronics and biomedicine. Over the past decade, quantum dots (QDs) become one of fastest growing areas nanotechnology because outstanding photophysical properties, including narrow symmetrical emission spectrum, broad fluorescence excitation tenability wavelength with particle size composition, anti-photobleaching ability stable fluorescence. These characteristics are suitable optical imaging, drug delivery other biomedical applications. Research on QDs toxicology has demonstrated affect or damage biological system some extent, this situation is generally caused by metal ions special properties QDs, which hinders further application field. The toxicological mechanism mainly stems from release heavy generation reactive oxygen species (ROS). At same time, contact reaction also cause disorders organelles changes gene expression profiles. In review, we try present an overview toxicity related mechanisms different target organs. It believed that evaluation synthesis environmentally friendly primary issues be addressed future widespread However, considering many types potential modifications, review still not clearly elucidated, needed meaningful topic. Keywords: dots, nanotoxicology, nanoparticle, toxicity, cytotoxic

Language: Английский

Citations

27
Disturbing cytoskeleton by engineered nanomaterials for enhanced cancer therapeutics DOI Creative Commons

Xueli Xu,

Shanbin Xu,

Jipeng Wan

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 29, P. 50 - 71

Published: June 29, 2023

Cytoskeleton plays a significant role in the shape change, migration, movement, adhesion, cytokinesis, and phagocytosis of tumor cells. In clinical practice, some anti-cancer drugs achieve cytoskeletal therapeutic effects by acting on different protein components. However, absence cell-specific targeting, unnecessary recombination organisms would be disastrous, which also bring about severe side during anticancer process. Nanomedicine have been proven to superior small molecule cancer treatment due better stability lower effects. Therefore, this review summarized recent developments various nanomaterials disturbing cytoskeleton for enhanced therapeutics, including carbon, noble metals, metal oxides, black phosphorus, calcium, silicon, polymers, peptides, metal-organic frameworks, etc. A comprehensive analysis characteristics therapy as well future prospects challenges towards application were discussed. We aim drive emerging topic through refreshing perspectives based our own work what we learnt from others. This will help researchers quickly understand relevant information further advance development nanomedicine.

Language: Английский

Citations

26
In-vitro Study of hybrid Silver Nanoparticles with Humic Acid extracted from Cow Dung against pathogens DOI Creative Commons

Shabir Ahmed Dharejo,

Tajnees Pirzada,

Muhammad Raza Shah

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(1), P. e41636 - e41636

Published: Jan. 1, 2025

Recently, researchers have used silver nanoparticles (AgNPs) coupled with humic acid (HA) as antimicrobial agents. Herein, AgNPs were prepared and for their activities. The as-prepared characterized by an atomic force microscope (AFM), X-ray powder diffraction (XRD), zeta potential, sizer, Fourier-transform infrared (FT-IR) spectroscopy, UV-VIS spectrophotometer. Moreover, human plasma, varied salt concentrations, pH levels stability confirmation using a antibacterial activities minimal bactericidal concentration (MBC) of determined disk diffusion broth dilution methods, respectively, against identified Staphylococcus aureus, Streptococcus pyogene, Pseudomonas aeruginosa, Escherichia coli, which are extracted from cow dung. AgNPs' peak in the UV-Vis spectral range showed maximal absorption at 415 nm. displayed distinctive under all circumstances, demonstrating stability. FT-IR functional groups such hydroxyl, carboxylic acids, carbonyl, ester, ether groups. particles face-centered cubic (FCC) structure, according to XRD. had spherical shape, high negative polydisperse nature, average size 25.43 was found be 2.5 mg/mL, MBC AgNPs/HA 5 mg/mL. result indicated that as-synthesizedAgNPs/HA more effective inhibiting studied microorganisms, can attributed therapeutic use coated acids.

Language: Английский

Citations

1