Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(9), P. 1332 - 1384
Published: March 14, 2023
Abstract
Conjugated
and
non‐conjugated
allenones
appear
as
recurring
motifs
in
organic
synthesis,
natural
products
mechanistic
investigations
showing
unique
properties
applications.
The
ability
of
to
build
cycles
has
provided
a
direct
access
strained
systems,
medium‐sized
rings,
arenes,
heterocycles
complex
polycycles.
In
addition,
have
served
models
catalysis.
critic
compilation
herein
presented
will
provide
an
exhaustive
overview
the
synthetic
possibilities
may
offer,
which
certainly
inspire
our
community
their
search
more
efficient
methodologies,
preparation
biological
pharmaceutical
targets,
improve
knowledge
theoretical
chemistry.
Great
part
this
review
discuss
aspects,
catalysis
innovation
insights
chemical
transformations
implying
allenone
motif.
many
examples
on
total
synthesis
pharmacologically
active
compounds
be
described.
We
hope
that
attractive
chemistry,
catalysis,
medicinal
chemistry
communities.
magnified
image
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(9), P. 1834 - 1839
Published: Feb. 22, 2024
Efficient
access
to
multiple
functionalized
allenes
via
a
three
component
1,4-alkylcyanation
of
enynes
with
cyclic
alcohol
derivatives
in
the
presence
trimethylsilyl
cyanide
(TMSCN)
under
copper/photoredox
dual
catalysis
has
been
developed.
Both
easily
transformable
aldehyde
and
cyano
groups
were
introduced
tetra-substituted
through
light-induced
C–C
bond
cleavage
butanol
pentanol
derivatives.
The
reactions
proceeded
smoothly
mild
conditions
broad
functional
tolerance.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(38), P. 7047 - 7051
Published: Sept. 19, 2022
Commercially
available
CF2Br2
has
been
used
as
a
convenient
source
for
the
rapid
and
reliable
incorporation
of
gem-difluorovinyl
motif
into
an
allene
framework
via
N-heterocyclic
carbene
catalyzed
difluoroolefination
1,3-enynes.
The
reaction
proceeds
through
cascade
three-component
radical
relay/elimination
process.
This
protocol
is
distinguished
by
its
mild
conditions,
readily
accessible
starting
materials,
wide
substrate
scope,
ease
late-stage
functionalization,
thus
unlocking
untraditional
strategy
to
construct
new
class
functionalized
allenes.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(9), P. 1332 - 1384
Published: March 14, 2023
Abstract
Conjugated
and
non‐conjugated
allenones
appear
as
recurring
motifs
in
organic
synthesis,
natural
products
mechanistic
investigations
showing
unique
properties
applications.
The
ability
of
to
build
cycles
has
provided
a
direct
access
strained
systems,
medium‐sized
rings,
arenes,
heterocycles
complex
polycycles.
In
addition,
have
served
models
catalysis.
critic
compilation
herein
presented
will
provide
an
exhaustive
overview
the
synthetic
possibilities
may
offer,
which
certainly
inspire
our
community
their
search
more
efficient
methodologies,
preparation
biological
pharmaceutical
targets,
improve
knowledge
theoretical
chemistry.
Great
part
this
review
discuss
aspects,
catalysis
innovation
insights
chemical
transformations
implying
allenone
motif.
many
examples
on
total
synthesis
pharmacologically
active
compounds
be
described.
We
hope
that
attractive
chemistry,
catalysis,
medicinal
chemistry
communities.
magnified
image
