Beilstein Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
19, P. 666 - 673
Published: May 12, 2023
The
importance
of
functionalized
imidazo
heterocycles
has
often
been
featured
in
several
impactful
research
both
from
academia
and
industry.
Herein,
we
report
a
direct
C-3
acetoxymalonylation
using
relay
C-H
functionalization
enabled
by
organophotocatalysis
starring
zinc
acetate
the
triple
role
an
activator,
ion
scavenger
as
well
acetylating
reagent.
mechanistic
investigation
revealed
sequential
sp2
sp3
activation,
followed
driven
coupled
with
photocatalyst
PTH.
A
variety
imidazo[1,2-a]pyridines
related
were
explored
substrates
along
active
methylene
reagents,
all
generating
products
excellent
yields
regioselectivity,
thus
confirming
functional
group
tolerability.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(32), P. 17527 - 17550
Published: Aug. 2, 2023
The
C–O
bond
is
ubiquitous
in
biologically
active
molecules,
pharmaceutical
agents,
and
functional
materials,
thereby
making
it
an
important
group.
Consequently,
the
development
of
bond-forming
reactions
using
catalytic
strategies
has
become
increasingly
research
topic
organic
synthesis
because
more
conventional
methods
involving
strong
base
acid
have
many
limitations.
In
contrast
to
ionic-pathway-based
methods,
copper-promoted
radical-mediated
formation
experiencing
a
surge
interest
owing
renaissance
free-radical
chemistry
photoredox
catalysis.
This
Perspective
highlights
appraises
state-of-the-art
techniques
this
burgeoning
field.
contents
are
organized
according
different
reaction
types
working
models.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(17), P. 4449 - 4462
Published: Jan. 1, 2023
A
new
kid
on
the
block:
Cu(
ii
)
offers
unique
possibilities
in
photocatalysis
for
generating
and
stabilizing
radicals
to
promote
challenging
synthetic
transformations.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(22), P. 6045 - 6051
Published: Jan. 1, 2023
A
photocatalytic
C-H
gem-difunctionalization
of
1,3-benzodioxoles
with
two
different
alkenes
for
the
synthesis
highly
functionalized
monofluorocyclohexenes
is
described.
Using
4CzIPN
as
photocatalyst,
direct
single
electron
oxidation
allows
their
defluorinative
coupling
α-trifluoromethyl
to
produce
gem-difluoroalkenes
in
a
redox-neutral
radical
polar
crossover
manifold.
The
bond
resultant
γ,γ-difluoroallylated
was
further
via
addition
electron-deficient
using
more
oxidizing
iridium
photocatalyst.
capture
situ
generated
carbanions
by
an
electrophilic
gem-difluoromethylene
carbon
and
consecutive
β-fluoride
elimination
afford
monofluorocyclohexenes.
synergistic
combination
multiple
termination
pathways
enables
rapid
incorporation
molecular
complexity
stitching
simple
readily
accessible
starting
materials
together.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(7), P. 4199 - 4208
Published: Jan. 1, 2024
A
new
photoelectrocatalytic
mode
permits
the
synthesis
of
polycyclic
pyrimidin-4-ones
through
dehydrogenative
cyclization
malonates
with
unactivated
alkenes.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(22)
Published: April 16, 2024
Abstract
In
this
study,
we
present
an
efficient
and
straightforward
dearomative
hydroalkylation
of
indoles.
By
utilizing
alkanes
or
ethers
as
alkyl
radical
sources
employing
TBADT
a
cost‐effective
photocatalyst
for
direct
hydrogen
atom
transfers
(HAT),
achieved
successful
conversion
these
heterocyclic
derivatives
into
2‐alkylindolines
with
good
to
excellent
yields
high
diastereoselectivity
under
mild
reaction
conditions.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(9), P. 957 - 962
Published: Jan. 18, 2024
Comprehensive
Summary
Multicomponent
alkene
1,2‐dicarbofunctionalizations
(DCFs)
have
emerged
as
a
powerful
strategy
to
rapidly
incorporate
both
two
carbon
subunits
across
one
C—C
double
bond
in
step
for
enhancing
molecular
complexity
and
diversity.
To
the
best
of
our
knowledge,
there
is
only
report
on
photoredox‐catalyzed
three‐component
DCFs
with
malonates
through
radical−radical
cross‐coupling,
while
radical‐polar
crossover
(RPC)‐type
were
still
rare.
Herein,
we
describe
redox‐neutral
RPC‐type
1,2‐dialkylation
styrenes
aldehydes
synergistic
Brønsted
base/photoredox
catalysis
system.
This
transition‐metal‐free
provides
an
efficient
clean
approach
broad
variety
δ‐hydroxy
esters
also
features
exceptionally
mild
conditions,
wide
compatibility
substrate
scope
functional
groups,
high
atomic
economy.
Moreover,
1,2‐alkylacylation
from
same
starting
materials
was
achieved
one‐pot
manner
such
coupling
subsequent
two‐electron
oxidation
process,
providing
set
δ‐keto
interest
pharmaceutical
research.
Synthesis,
Journal Year:
2023,
Volume and Issue:
56(13), P. 1967 - 1978
Published: Nov. 21, 2023
Abstract
The
absorption
of
light
by
photosensitizers
has
been
shown
to
offer
novel
reactive
pathways
through
electronic
excited
state
intermediates,
complementing
ground-state
mechanisms.
Such
strategies
have
applied
in
both
photocatalysis
and
photoredox
catalysis,
driven
generating
intermediates
from
their
long-lived
states.
One
developing
area
is
photoinduced
ligand-to-metal
charge
transfer
(LMCT)
which
coordination
a
ligand
metal
center
subsequent
excitation
with
results
the
formation
radical
reduced
center.
This
mini
review
concerns
foundations
recent
developments
on
transition-metal
focusing
organic
transformations
made
possible
this
mechanism.
1
Introduction
2
Iron
3
Cobalt
4
Nickel
5
Copper
6
Future
Outlook
Conclusion
