A
photoredox/nickel
dual
catalysis
is
presented
for
the
construction
of
several
kinds
useful
nitrogen-containing
heterocycles.
This
protocol
regioselective
and
features
a
broad
substrate
scope.
It
provides
direct
access
to
heterocycles
by
reacting
alkyl
chlorides
with
readily
available
activated
unactivated
alkenes.
Moreover,
this
can
be
easily
scalable
gram-scale,
it
feasible
use
sunlight
as
light
source.
Mechanistic
studies
suggest
that
energy
transfer
pathway
involved
in
catalytic
process.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Reported
herein
is
a
novel
ruthenium(II)-catalyzed
[4
+
2]
annulation
of
quinazolinones
with
1,2-dichloroethane
(DCE),
resulting
in
myriad
isoquinolino[1,2-b]quinazolinone
scaffolds.
In
this
protocol,
DCE
serves
not
only
as
solvent
but
also
an
acetylene
source.
The
fused
undergo
versatile
transformations
and
provide
rapid
convenient
way
to
access
several
important
bioactive
molecule
analogues
such
Rutecarpine,
Euxylophoricine
B
E.
potential
reaction
pathway
was
elucidated
through
detailed
mechanistic
studies
Density
Functional
Theory
(DFT)
calculations.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(45), P. 8178 - 8182
Published: Nov. 7, 2023
CO2-assisted
and
Ni-catalyzed
direct
reductive
allylation
of
aldehydes
utilizing
allylic
alcohols
as
precursor
has
been
reported.
Various
homoallyl
could
be
synthesized
in
excellent
yield
with
enhanced
regioselectivity
stereoselectivity
for
alkyl-
aryl-substituted
under
mild
conditions.
For
different
substrates,
proper
collocation
the
catalytic
ligand
is
crucial.
Preliminary
mechanistic
studies
supported
reaction
pathway
through
a
sequential
allyl
hydrocarbonate
formation/allylnickelation/coordination
insertion
process
by
Ni(I)/Ni(III)
cycle,
which
proven
cyclic
voltammetry
analysis.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
89(2), P. 825 - 834
Published: Dec. 28, 2023
The
participation
of
σ-monocopper
and
σ-bis-copper
acetylide
in
mechanistic
pathways
for
copper-catalyzed
cycloaddition
(CuAAC)
reactions
acetylene
with
azides
was
probed
by
analysis
deuterium
distributions
the
1,2,3-triazole
product
formed
deuterolysis
initially
mono-
bis-copper
triazoles.
results
show
that,
when
Cu(Phen)(PPh3)2NO3
is
used
as
catalyst
DMF/D2O,
1-substituted-5-deutero-1,2,3-triazoles
are
generated
selectively.
This
finding
demonstrates
that
Cu(Phen)(PPh3)2NO3-catalyzed
cycloadditions
utilize
monocopper
substrate
produce
5-copper-1,2,3-triazoles
initially.
Conversely,
DBU
or
Et3N
copper
ligand,
process
takes
place
through
initial
formation
to
4,5-bis-copper-triazole,
which
reacts
D2O
form
corresponding
4,5-bis-deutero-triazole.
Moreover,
C2D2
substrate,
Cu
H2O/DMF
solvent,
mono-C4-deutreo
1,2,3-triazoles
high
yields
excellent
levels
regioselectivity.
Lastly,
CuAAC
azides,
promoted
CuCl2·2H2O
NaI,
yield
4,5-diiodo-1,2,3-triazoles
moderate
efficiencies.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(16), P. 2558 - 2564
Published: May 23, 2024
Abstract
A
dual
cobalt
and
chromium
photoredox-catalyzed
allylation
of
aldehydes
with
allenes
through
a
photo
metal-hydride
atom
transfer
(MHAT)
process
has
been
developed
to
yield
homoallylic
alcohols
exceptional
diastereoselective
control.
This
sustainable
efficient
method
holds
significant
promise
for
applications
in
the
synthesis
valuable
organic
compounds.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 10, 2024
The
development
of
all
kinds
covalent
drugs
had
a
major
impact
on
the
improvement
human
health
system.
Covalent
binding
to
target
proteins
is
achieved
by
so-called
electrophilic
warheads,
which
are
incorporated
in
respective
drug
molecule.
In
last
decade,
specifically
acrylamides
emerged
as
attractive
warheads
design.
Herein,
straightforward
palladium-catalyzed
hydroaminocarbonylation
acetylene
has
been
developed,
allowing
modular
and
diverse
synthesis
bio-active
acrylamides.
This
general
protocol
features
high
atom
efficiency,
wide
functional
group
compatibility,
chemoselectivity
proceeds
additive
free
under
mild
reaction
conditions.
synthetic
utility
this
showcased
ibrutinib,
osimertinib,
other
compound
derivatives.
