Asymmetric cycloisomerization/[3 + 2] cycloaddition for the synthesis of chiral spiroisobenzofuran-1,3′-pyrrolidine derivatives DOI
Pei Dong, Long Chen, Zhendong Yang

et al.

Organic Chemistry Frontiers, Journal Year: 2021, Volume and Issue: 8(24), P. 6874 - 6880

Published: Jan. 1, 2021

An asymmetric tandem cycloisomerization/[3 + 2] cycloaddition reaction of 2,2′-diester aziridine and 2-ethynyl benzyl alcohol with Au( i )/chiral N , ′-dioxide−Dy( iii ) as a relay catalyst system was developed.

Language: Английский

Catalytic Asymmetric Hydroacyloxylation/Ring-Opening Reaction of Ynamides, Acids, and Aziridines DOI

Xiangqiang Li,

Hongkun Zeng,

Lili Lin

et al.

Organic Letters, Journal Year: 2021, Volume and Issue: 23(8), P. 2954 - 2958

Published: March 26, 2021

A highly enantioselective three-component reaction of ynamides with carboxylic acids and 2,2′-diester aziridines has been realized by using a chiral N,N′-dioxide/Ho(OTf)3 complex as Lewis acid catalyst. The process includes the formation an α-acyloxyenamide intermediate through addition to following nucleophilic in-situ-generated azomethine ylides induced range amino acyloxyenamides are delivered in moderate good yields ee values. In addition, possible catalytic cycle transition model is proposed elucidate mechanism.

Language: Английский

Citations

10
Asymmetric synthesis of polycyclic spiroindolines via the Dy-catalyzed cascade reaction of 3-(2-isocyanoethyl)indoles with aziridines DOI
Pei Dong, Zhaojing Li, Xiaohua Liu

et al.

Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(17), P. 4591 - 4597

Published: Jan. 1, 2022

An asymmetric cascade reaction catalyzed by a chiral N , ′-dioxide–Dy( iii ) complex was realized to construct the valuable [6,5,5,6] tetracyclic spiroindolines with good yields and enantioselectivities concise one-step protocol.

Language: Английский

Citations

7
TfOH-catalyzed formal [3+2] cycloaddition of N-tosylaziridine dicarboxylates and nitriles: Synthesis of tetrafunctionalized 2-imidazolines DOI

Qinglu Zuo,

Zhichao Shi, Feng Zhan

et al.

Tetrahedron Letters, Journal Year: 2019, Volume and Issue: 61(10), P. 151576 - 151576

Published: Dec. 30, 2019

Language: Английский

Citations

10
NHC-catalyzed [4 + 2] annulations of allenoates and 2,3-dioxopyrrolidine derivatives DOI
Song Xue,

Yangxu Chen,

Fangfang Lu

et al.

Organic & Biomolecular Chemistry, Journal Year: 2022, Volume and Issue: 20(6), P. 1219 - 1225

Published: Jan. 1, 2022

A facile NHC-catalyzed [2 + 4] annulation of allenoates with 2,3-dioxypyrrolidine derivatives was discovered, which paved a new avenue for the construction highly substituted pyranopyrrole moderate to good yields, high atom economy and mild reaction conditions.

Language: Английский

Citations

6
Asymmetric cycloisomerization/[3 + 2] cycloaddition for the synthesis of chiral spiroisobenzofuran-1,3′-pyrrolidine derivatives DOI
Pei Dong, Long Chen, Zhendong Yang

et al.

Organic Chemistry Frontiers, Journal Year: 2021, Volume and Issue: 8(24), P. 6874 - 6880

Published: Jan. 1, 2021

An asymmetric tandem cycloisomerization/[3 + 2] cycloaddition reaction of 2,2′-diester aziridine and 2-ethynyl benzyl alcohol with Au( i )/chiral N , ′-dioxide−Dy( iii ) as a relay catalyst system was developed.

Language: Английский

Citations

8