Organic Reaction Mechanisms/Organic reaction mechanisms,
Journal Year:
2024,
Volume and Issue:
unknown, P. 237 - 266
Published: March 15, 2024
Multilevel
quantum
mechanics
and
molecular
calculations
have
been
used
to
investigate
the
double
inversion
mechanism
of
nucleophilic
substitution
reaction
F
-
+
NH
2
Cl
in
aqueous
solution.
The
nickel-catalyzed
generation
homoenolates
by
decarbonylation
cyclic
anhydrides
their
cross-coupling
with
unactivated
alkyl
bromides
has
access
substituted
aliphatic
acids.
acetoxy
derivative
(77b)
galiellalactone
(77a)
smoothly
undergoes
a
stereoretentive
at
tetrasubstituted
carbon,
using
primary
amine
thiol
nucleophiles
or
alcohols,
presence
catalytic
amounts
DMAP.
reactions
proceed
initial
allylic
form
new
Michael
acceptor,
followed
addition
second
equivalent
nucleophile
then
retro-Michael
restore
unsaturated
system.
Journal of Materials Chemistry A,
Journal Year:
2021,
Volume and Issue:
9(44), P. 25128 - 25135
Published: Jan. 1, 2021
A
green
and
gram-scale
strategy
has
been
developed
for
the
synthesis
of
Fe
single
atom/N,S-doped
carbon
catalyst
via
pyrolysis
polyaniline-modified
Fe,S-doped
ZIFs,
in
which
ZIFs
can
be
prepared
water
at
room
temperature.
ACS Catalysis,
Journal Year:
2022,
Volume and Issue:
12(8), P. 4481 - 4490
Published: April 1, 2022
Selective
synthesis
of
valuable
secondary
amines
through
N-alkylation
with
alcohols
is
an
important
reaction
in
the
modern
industry
but
still
remains
a
challenge
chemical
technique.
Hereby,
we
report
visible-light-driven
photocatalytic
aniline
benzyl
alcohol
over
defined
single
Pd–Sx
species
situ
coordinated
on
CdS
surface.
Encouragingly,
conversion
100%
and
almost
product
selectivity
toward
amine
N-benzylaniline
are
obtained
impressive
H2
production
(11.8
mmol
gcat–1
h–1).
The
mechanistic
studies
reveal
that
surface
can
trap
photogenerated
electrons
to
endow
them
long
lifetime
benefit
vibrational
coupling
hydrogen
adsorption
then
serve
as
efficient
autotransfer
shuttle
for
hydrogenation
process
formation
N-benzylaniline.
In
addition,
present
catalyst
possesses
good
substrate
tolerance
different
substituted
under
optimized
conditions.
This
work
offers
alternative
solar-driven
catalytic
system
mild
ACS Catalysis,
Journal Year:
2023,
Volume and Issue:
13(8), P. 5584 - 5598
Published: April 10, 2023
Amine
transaminases
constitute
an
important
class
of
enzymes
for
the
synthesis
chiral
amines,
which
are
commonly
used
as
building
blocks
in
pharmaceutical
compounds
and
fine
chemicals.
Over
past
decade,
developments
enzyme
discovery
process
protein
engineering
have
advanced
use
organic
synthesis.
Recent
advances
enzymatic
cascade
attracted
attention
due
to
efficient
environmentally
friendly
routes
synthesize
amines.
Enzymatic
cascades
can
reduce
traditional
multistep
enabled
generation
products
from
cheap
starting
materials.
This
review
focuses
on
amine
by
chemoenzymatic
utilizing
transaminases.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
88(2), P. 771 - 787
Published: Dec. 28, 2022
We
report
a
sustainable
and
eco-friendly
approach
for
selective
N-alkylation
of
various
amines
by
alcohols,
catalyzed
well-defined
Zn(II)-catalyst,
Zn(La)Cl2
(1a),
bearing
tridentate
arylazo
scaffold.
A
total
57
N-alkylated
were
prepared
in
good
to
excellent
yields,
out
which
17
examples
are
new.
The
Zn(II)-catalyst
shows
wide
functional
group
tolerance,
is
compatible
with
the
synthesis
dialkylated
via
double
diamines,
produces
precursors
high
yields
marketed
drugs
tripelennamine
thonzonium
bromide
gram-scale
reactions.
Control
reactions
DFT
studies
indicate
that
electron
transfer
events
occur
at
azo-chromophore
throughout
catalytic
process,
shuttles
between
neutral
azo,
one-electron
reduced
azo-anion
radical,
two-electron
hydrazo
forms
acting
both
as
hydrogen
reservoir,
enabling
reaction.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(3), P. 445 - 445
Published: Jan. 21, 2023
S-doping
emerged
as
a
promising
approach
to
further
improve
the
catalytic
performance
of
carbon-based
materials
for
organic
synthesis.
Herein,
facile
and
gram-scale
strategy
was
developed
using
zeolitic
imidazole
frameworks
(ZIFs)
precursor
fabrication
ZIF-derived
N,
S
co-doped
carbon-supported
zinc
single-atom
catalyst
(CNS@Zn1-AA)
via
pyrolysis
S-doped
ZIF-8,
which
modified
by
aniline,
ammonia
thiourea
prepared
one-pot
ball
milling
at
room
temperature.
This
catalyst,
in
Zn
is
dispersed
single
atom,
displays
superior
activity
N-alkylation
hydrogen-borrowing
(120
°C,
turnover
frequency
(TOF)
up
8.4
h−1).
significantly
enhanced
CNS@Zn1-AA,
it
increased
specific
surface
area
defects
this
material
simultaneously
electron
density
sites
catalyst.
Furthermore,
had
excellent
stability
recyclability,
no
obvious
loss
after
eight
runs.
Catalysis Science & Technology,
Journal Year:
2024,
Volume and Issue:
14(7), P. 1958 - 1966
Published: Jan. 1, 2024
Herein,
atomically
dispersed
Ru
sites
are
encapsulated
within
UiO-66–NH
2
frameworks
to
serve
as
a
highly
active,
selective,
and
stable
catalyst
for
amine
synthesis
via
N
-alkylation
reactions
of
o
-phenylenediamine
with
monohydric
alcohols.
